目的研究慢性鼻窦炎鼻息肉(chronic rhinosinusitis and nasal polyps,CRSwNP)患者使用糖皮质激素联合鼻内镜手术治疗的临床效果。方法在2017年5月~2020年9月于本院选取128例CRSwNP患者,使用随机数字表法分为参照组和研究组,每组64例,...目的研究慢性鼻窦炎鼻息肉(chronic rhinosinusitis and nasal polyps,CRSwNP)患者使用糖皮质激素联合鼻内镜手术治疗的临床效果。方法在2017年5月~2020年9月于本院选取128例CRSwNP患者,使用随机数字表法分为参照组和研究组,每组64例,对比两组治疗后临床效果。结果研究组较参照组总有效率较高(P<0.05);两组治疗前鼻腔容积(nasalcavityvolume,NCV)对比无差异(P>0.05),治疗后研究组较参照组优(P<0.05)。结论对CRSwNP患者给予糖皮质激素联合鼻内镜手术治疗可提升治疗效果,加快患者恢复速度,改善其鼻腔功能,值得借鉴。展开更多
A series of anthracene-based derivatives, namely, 9-（4-phenyl）anthracene（1）, 9-（4-phenylethynyl）- anthracene（2） and 9, 10-bis（phenylethynyl）anthracene（3）, was synthesized by the Suzuki/Sonogashira cross-co...A series of anthracene-based derivatives, namely, 9-（4-phenyl）anthracene（1）, 9-（4-phenylethynyl）- anthracene（2） and 9, 10-bis（phenylethynyl）anthracene（3）, was synthesized by the Suzuki/Sonogashira cross-coupling reactions in good yields. These compounds were fully characterized by X-ray crystallography, thermogravimetric analysis（TGA）, differential scanning calorimetry（DSC）, UV-Vis absorption and fiuorescence（FL） spectroscopy, as well as density functional theory（DFT） calculations. Single-crystal X-ray analysis revealed that the packing structures were influenced by the terminal substitutions. All the compounds exhibited high thermal stability（Td=221---484 ~C） and blue emission with a high quantum yield（~bf =0.20--0.75）. As the number of substituents increased, the decomposition temperatures（Td） of these compounds increased in the following order： 1〈2〈3. Experiments on the photophysical properties revealed that different substituents strongly affected the optical properties. In particular, compound lb with the electron-withdrawing group（--CHO） exhibited a larger Stokes shift（113 nm） than the other compounds. Investigation of the electrochemical properties of these compounds showed that the HOMO-LUMO energy gaps（Egap） decreased obviously as the degree of conjugation increased.展开更多
文摘目的研究慢性鼻窦炎鼻息肉(chronic rhinosinusitis and nasal polyps,CRSwNP)患者使用糖皮质激素联合鼻内镜手术治疗的临床效果。方法在2017年5月~2020年9月于本院选取128例CRSwNP患者,使用随机数字表法分为参照组和研究组,每组64例,对比两组治疗后临床效果。结果研究组较参照组总有效率较高(P<0.05);两组治疗前鼻腔容积(nasalcavityvolume,NCV)对比无差异(P>0.05),治疗后研究组较参照组优(P<0.05)。结论对CRSwNP患者给予糖皮质激素联合鼻内镜手术治疗可提升治疗效果,加快患者恢复速度,改善其鼻腔功能,值得借鉴。
基金Supported by the National Natural Science Foundation of Chflm（Nos.21602014, 61474144）, the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry of China, the Fund Program for the Scientific Activities of Selected Returned Overseas Professionals of Beijing, China, the Scientific Research Common Program of Beijing Municipal Commission of Education, China, the Doctoral Scientific Research Foundation of Beijing Institute of Graphic Com- munication（BIGC）（No.KM201510015003） and the BIGC Project, China（Nos. 20190116002/043, 04190117001/019）.
文摘A series of anthracene-based derivatives, namely, 9-（4-phenyl）anthracene（1）, 9-（4-phenylethynyl）- anthracene（2） and 9, 10-bis（phenylethynyl）anthracene（3）, was synthesized by the Suzuki/Sonogashira cross-coupling reactions in good yields. These compounds were fully characterized by X-ray crystallography, thermogravimetric analysis（TGA）, differential scanning calorimetry（DSC）, UV-Vis absorption and fiuorescence（FL） spectroscopy, as well as density functional theory（DFT） calculations. Single-crystal X-ray analysis revealed that the packing structures were influenced by the terminal substitutions. All the compounds exhibited high thermal stability（Td=221---484 ~C） and blue emission with a high quantum yield（~bf =0.20--0.75）. As the number of substituents increased, the decomposition temperatures（Td） of these compounds increased in the following order： 1〈2〈3. Experiments on the photophysical properties revealed that different substituents strongly affected the optical properties. In particular, compound lb with the electron-withdrawing group（--CHO） exhibited a larger Stokes shift（113 nm） than the other compounds. Investigation of the electrochemical properties of these compounds showed that the HOMO-LUMO energy gaps（Egap） decreased obviously as the degree of conjugation increased.
