Foundation settlement is of great significance for high-fill engineering in collapsible loess areas.To predict the construction settlement of Lüliang Airport located in Shanxi Province,China,a plane strain finite...Foundation settlement is of great significance for high-fill engineering in collapsible loess areas.To predict the construction settlement of Lüliang Airport located in Shanxi Province,China,a plane strain finite element method considering the linear variation in the modulus,was carried out in this paper based on the results of geotechnical tests.The stress and deformation of four typical sections caused by layered fill are simulated,and then the settlement of the high-fill airport is calculated and analyzed by inputting three sets of parameters.The relative soft parameters of loess geomaterials produce more settlement than the relatively hard parameters.The thicker the filling body is,the greater the settlement is.The filling body constrained by mountains on both sides produces less settlement than the filling body constrained by a mountain on only one side even the filling thickness is almost the same.The settlement caused by the original subbase accounts for 56%−77%of the total settlement,while the fill soils themselves accounts for 23%−44%of the total settlement,which is approximately consistent with the field monitoring results.It provides a good reference for predicting the settlement of similar high-fill engineering.展开更多
采用代谢组学方法探究炙淫羊藿温肾助阳和炮制增效机制。建立氢化可的松诱导的大鼠肾阳虚证模型,基于UPLC-Q-TOF-MS(ultra-performance liquid chromatography with quadrupole time-of-flight tandem mass spectrometry)代谢组学方法,...采用代谢组学方法探究炙淫羊藿温肾助阳和炮制增效机制。建立氢化可的松诱导的大鼠肾阳虚证模型,基于UPLC-Q-TOF-MS(ultra-performance liquid chromatography with quadrupole time-of-flight tandem mass spectrometry)代谢组学方法,联合多元统计分析和单变量统计分析,筛选并鉴定血浆、尿液样品中与肾阳虚相关的潜在生物标志物,分析羊脂油组、淫羊藿生品组、淫羊藿加热品组、淫羊藿炙品组改善肾阳虚证的代谢调控机制。结果显示,氢化可的松诱导的肾阳虚大鼠血浆、尿液代谢呈现明显的轨迹变化,在血浆和尿液中鉴定出15种与肾阳虚相关的生物标志物,涉及5条代谢通路,分别为甘油磷脂代谢、鞘脂代谢、硫代谢、乙醛酸和二羧酸代谢、半胱氨酸和蛋氨酸代谢。炙淫羊藿温肾助阳的代谢通路涉及甘油磷脂代谢、半胱氨酸和蛋氨酸代谢,而炙淫羊藿两个炮制因素“加热”“羊脂油”分别通过调节甘油磷脂代谢、半胱氨酸和蛋氨酸代谢来增强其温肾助阳的作用,进而阐明了炙淫羊藿的炮制增效机制。本文涉及的动物实验符合伦理学标准,并且已获得江苏省中医药研究院动物伦理委员会批准(批准号:AEWC-20200702-119)。展开更多
基金Project(2020M670604)supported by the China Postdoctoral Science FoundationProject(41790434)supported by the National Natural Science Foundation of China。
文摘Foundation settlement is of great significance for high-fill engineering in collapsible loess areas.To predict the construction settlement of Lüliang Airport located in Shanxi Province,China,a plane strain finite element method considering the linear variation in the modulus,was carried out in this paper based on the results of geotechnical tests.The stress and deformation of four typical sections caused by layered fill are simulated,and then the settlement of the high-fill airport is calculated and analyzed by inputting three sets of parameters.The relative soft parameters of loess geomaterials produce more settlement than the relatively hard parameters.The thicker the filling body is,the greater the settlement is.The filling body constrained by mountains on both sides produces less settlement than the filling body constrained by a mountain on only one side even the filling thickness is almost the same.The settlement caused by the original subbase accounts for 56%−77%of the total settlement,while the fill soils themselves accounts for 23%−44%of the total settlement,which is approximately consistent with the field monitoring results.It provides a good reference for predicting the settlement of similar high-fill engineering.
文摘采用代谢组学方法探究炙淫羊藿温肾助阳和炮制增效机制。建立氢化可的松诱导的大鼠肾阳虚证模型,基于UPLC-Q-TOF-MS(ultra-performance liquid chromatography with quadrupole time-of-flight tandem mass spectrometry)代谢组学方法,联合多元统计分析和单变量统计分析,筛选并鉴定血浆、尿液样品中与肾阳虚相关的潜在生物标志物,分析羊脂油组、淫羊藿生品组、淫羊藿加热品组、淫羊藿炙品组改善肾阳虚证的代谢调控机制。结果显示,氢化可的松诱导的肾阳虚大鼠血浆、尿液代谢呈现明显的轨迹变化,在血浆和尿液中鉴定出15种与肾阳虚相关的生物标志物,涉及5条代谢通路,分别为甘油磷脂代谢、鞘脂代谢、硫代谢、乙醛酸和二羧酸代谢、半胱氨酸和蛋氨酸代谢。炙淫羊藿温肾助阳的代谢通路涉及甘油磷脂代谢、半胱氨酸和蛋氨酸代谢,而炙淫羊藿两个炮制因素“加热”“羊脂油”分别通过调节甘油磷脂代谢、半胱氨酸和蛋氨酸代谢来增强其温肾助阳的作用,进而阐明了炙淫羊藿的炮制增效机制。本文涉及的动物实验符合伦理学标准,并且已获得江苏省中医药研究院动物伦理委员会批准(批准号:AEWC-20200702-119)。
