AIM: To determine the expressions of cysteinyl leukotriene receptors, CysLT, and CysLT2 , in airway eosinophilic inflammation of OVA-induced asthmatic mice and the modulation by montelukast, a CysLT1 receptor antagoni...AIM: To determine the expressions of cysteinyl leukotriene receptors, CysLT, and CysLT2 , in airway eosinophilic inflammation of OVA-induced asthmatic mice and the modulation by montelukast, a CysLT1 receptor antagonist. METHODS: Asthma model was induced by chronic exposure to ovalbumin (OVA) in C57BL/6 mice. The eosinophils展开更多
AIM : To observe time course of neurological deficits after focal cerebral ischemia in mice, and to confirm the quantitative and objective method we developed for evaluating neurological deficits. METHODS: Focal cereb...AIM : To observe time course of neurological deficits after focal cerebral ischemia in mice, and to confirm the quantitative and objective method we developed for evaluating neurological deficits. METHODS: Focal cerebral ischemia was induced by middle cerebral artery occlusion. The neurological deficits were assessed 6 h, 12 h, 24 h, or 1-7 d after ischemia.展开更多
AIM: To determine whether pranlukast (ONO-1078 ), a cysteinyl leukotriene receptor antagonist, possesses therapeutic effect when administered after focal cerebral ischemia in mice. METHODS： Persistent focal cerebral ...AIM: To determine whether pranlukast (ONO-1078 ), a cysteinyl leukotriene receptor antagonist, possesses therapeutic effect when administered after focal cerebral ischemia in mice. METHODS： Persistent focal cerebral ischemia was induced by middle cerebral artery occlusion, pranlukast and edaravone, a positive control drug, were ip injected 1, 6展开更多
文摘AIM: To determine the expressions of cysteinyl leukotriene receptors, CysLT, and CysLT2 , in airway eosinophilic inflammation of OVA-induced asthmatic mice and the modulation by montelukast, a CysLT1 receptor antagonist. METHODS: Asthma model was induced by chronic exposure to ovalbumin (OVA) in C57BL/6 mice. The eosinophils
文摘AIM : To observe time course of neurological deficits after focal cerebral ischemia in mice, and to confirm the quantitative and objective method we developed for evaluating neurological deficits. METHODS: Focal cerebral ischemia was induced by middle cerebral artery occlusion. The neurological deficits were assessed 6 h, 12 h, 24 h, or 1-7 d after ischemia.
文摘AIM: To determine whether pranlukast (ONO-1078 ), a cysteinyl leukotriene receptor antagonist, possesses therapeutic effect when administered after focal cerebral ischemia in mice. METHODS： Persistent focal cerebral ischemia was induced by middle cerebral artery occlusion, pranlukast and edaravone, a positive control drug, were ip injected 1, 6
