Immunological disturbance effect of exogenous histamine towards key immune cells

Histamine in food has attracted widespread attention due to the potential toxicity and associated health risk.However,its influences on immunological components,especially the function of key immune cells,are still poorly known.In this work,we explored the effects of exogenous histamine on the function of key immune cells such as intestinal epithelial cells,dendritic cells,and T cells.The results showed that histamine could affect the expression of allergy-related genes in CMT93 cells at a high dose of histamine.Moreover,it’s found that histamine could cause an imbalance in the levels of relevant immune factors secreted by dendritic cells and T cells,especially those related to allergy.At the same time,the proportion of MHC class IIpositive dendritic cells and the proportion of T helper 2(Th2)cells in CD4^(+)T cells increased after histamine stimulation.We concluded that the presence of a certain level of histamine in food may affect the expression of allergy-related cytokines,disrupt the balance of the immune homeostasis,and potentially lead to adverse immune reactions.This work demonstrated the importance of including the estimation of histamine’s immune safety in aquatic products rather than merely considering the potential risk of food poisoning.

整合式理论下化工虚拟教研室建设的挑战及实现路径

虚拟教研室是在教育数字化背景下高校基层教学组织建设的创新性探索,在推动专业建设、课程建设、教学改革研究中有重要作用。本文在介绍整合式理论的基础上,阐释了现有化工教研室存在的创新模式、师资匹配、智能资源整合不足的问题。将整合式理论同教研室特征进行结合,分析了虚拟教研室在整合式理论下的应然状态,探索了创建跨界模式、构建进阶指导、共享线上资源的三种虚拟教研实现途径。虚拟教研室运行三年来,提高了教师教学能力和化工类应用型才培养质量。

Variation in concentration of dissolved silicate in the Eastern Philippine deep sea

Upper Circumpolar Deep Water(UCDW)and North Pacifi c Deep Water(NPDW)coexist in the upper deep layer(i.e.,with a 1.2-2.0-℃potential temperature range and a 2000-4100-dbar pressure range)of the Eastern Philippine Sea.They have similar properties in potential temperature and salinity,while have a signifi cant diff erence in dissolved silicate.Based on the repeated observations along a 137°E transect from the World Ocean Database(WOD18),this study revealed the interannual variability of dissolved silicate in the upper deep layer of the Eastern Philippine Sea.Dissolved silicate increased in 1995,1996,2005,2006,and 2007,and decreased in 1997,2000,2001,2002,and 2004.Composition analysis showed that the large diff erence between positive and negative dissolved silicate anomalies occurred mainly at~15°N and north of 25°N,with the concentration reaching 4.25μmol/g.Further analysis indicated that the interannual dissolved silicate variability was related to the zonal current variation in the upper deep layer.The relatively strong(weak)westward current transport increased(decreased)NPDW to the Eastern Philippine Sea,thereby resulting in increased(decreased)dissolved silicate.

Mechanism and Method of Testing Fracture Toughness and Impact Absorbed Energy of Ductile Metals by Spherical Indentation Tests

To address the problem of conventional approaches for mechanical property determination requiring destructive sampling, which may be unsuitable for in-service structures, the authors proposed a method for determining the quasi-static fracture toughness and impact absorbed energy of ductile metals from spherical indentation tests (SITs). The stress status and damage mechanism of SIT, mode I fracture, Charpy impact tests, and related tests were frst investigated through fnite element (FE) calculations and scanning electron microscopy (SEM) observations, respectively. It was found that the damage mechanism of SITs is diferent from that of mode I fractures, while mode I fractures and Charpy impact tests share the same damage mechanism. Considering the diference between SIT and mode I fractures, uniaxial tension and pure shear were introduced to correlate SIT with mode I fractures. Based on this, the widely used critical indentation energy (CIE) model for fracture toughness determination using SITs was modifed. The quasi-static fracture toughness determined from the modifed CIE model was used to evaluate the impact absorbed energy using the dynamic fracture toughness and energy for crack initiation. The efectiveness of the newly proposed method was verifed through experiments on four types of steels: Q345R, SA508-3, 18MnMoNbR, and S30408.

Optimizing Spatial Relationships in GCN to Improve the Classification Accuracy of Remote Sensing Images

Semantic segmentation of remote sensing images is one of the core tasks of remote sensing image interpretation.With the continuous develop-ment of artificial intelligence technology,the use of deep learning methods for interpreting remote-sensing images has matured.Existing neural networks disregard the spatial relationship between two targets in remote sensing images.Semantic segmentation models that combine convolutional neural networks(CNNs)and graph convolutional neural networks(GCNs)cause a lack of feature boundaries,which leads to the unsatisfactory segmentation of various target feature boundaries.In this paper,we propose a new semantic segmentation model for remote sensing images(called DGCN hereinafter),which combines deep semantic segmentation networks(DSSN)and GCNs.In the GCN module,a loss function for boundary information is employed to optimize the learning of spatial relationship features between the target features and their relationships.A hierarchical fusion method is utilized for feature fusion and classification to optimize the spatial relationship informa-tion in the original feature information.Extensive experiments on ISPRS 2D and DeepGlobe semantic segmentation datasets show that compared with the existing semantic segmentation models of remote sensing images,the DGCN significantly optimizes the segmentation effect of feature boundaries,effectively reduces the noise in the segmentation results and improves the segmentation accuracy,which demonstrates the advancements of our model.

太平洋中的主要起伏模态（英文）

对海洋中起伏运动(heaving)信号的时空分布研究能够帮助我们更好地了解气候系统中的年际和年代际变率。文章通过再分析资料和模式对太平洋区域的heaving主要模态进行了研究。研究结果表明:太平洋区域主要存在两种heaving模态:第一模态主要表现为赤道东西两侧的温跃层异常信号反位相;第二模态表现为赤道区域和副热带区域的温跃层异常信号呈现反位相变化的规律。本文对这两个主要heaving模态所涉及的物理过程进行详细讨论,结果表明:东西反位相模态主要是受赤道波动调节的结果;而经向结构模态则主要是由赤道地区的波动和副热带区域的风应力旋度异常作用共同导致。此外,我们还讨论了heaving模态可以通过海洋波动以及Ekman输送等过程对海盆尺度的热输送(振幅约为5x1014W)以及海洋热含量(振幅约为1.5x1020J)的再分配起到了关键的调制作甩进一步表明heaving模态对全球气候变化有着重要的作用。

Heat contribution of the Indonesian throughflow to the Indian Ocean

Based on the high-resolution Eulerian fields of an ocean general circulation model simulation, the heat contribution of the Indonesian throughflow(ITF) to the Indian Ocean is estimated by Lagrangian tracing method.The heat transport of each particle of ITF waters is calculated by tracing temperature change along the trajectory until the particle exits the Indian Ocean. The simulation reveals that the ITF waters flow westward and branch near Madagascar, further showing the ITF waters are redistributed in both northern and southern Indian Ocean.Heat budget analysis indicates that the ITF waters gain 0.41 PW(Petawatts, 1015 W) in the northern Indian Ocean and lose 0.56 PW in the southern Indian Ocean, respectively. As a result, the ITF waters warm the whole Indian Ocean basin with only 0.15 PW, which shows an "insignificant" role of ITF on the Indian Ocean because of the heat exchange compensation between northern and southern Indian Ocean. Furthermore, the tracing pathways show that the ITF waters mainly flow out the Indian Ocean at both sides of the basin via Agulhas Current and Leeuwin Current. About 89% of the ITF waters leave along western boundary and the rest 11% along eastern boundary. Compared to seeding section, 0.10 PW and 0.05 PW are released to the Indian Ocean, respectively.

Bonding strength of graded anti-corrosive coatings of fluoroethylenepropylene (FEP)/polyphenylene sulfide (PPS)

Fluororesin-based anti-corrosive coatings including graded FEP/PPS were prepared on carbon steel by melt powder coating, the bonding strength of all coating systems was determined by the pull-off test. It is found that the poor adhesion of fluororesin coatings to metallic substrates is improved obviously by the graded coating structure of FEP/PPS, and the bonding strength reaches up to 11.8 MPa for the five-layer system. Examination by electron probe microanalysis （EPMA） verifies that the distribution of main components is graded in the five-layer system, which is responsible for the enhancement of the interfacial bonding.

Decadal variation and trend of the upper layer salinity in the South China Sea from 1960 to 2010

Ocean salinity is an essential measurable indicator of water cycle and plays a crucial role in regulating ocean and climate change.Using Simple Ocean Data Assimilation(SODA)reanalysis product,substantial decadal variability of the salinity in the upper layer of the South China Sea(SCS)from 1960 to 2010 was examined.Results show that a decadal variation of the upper layer salinity is clear.The upper layer(100 m)waters are found to freshen from 1960,become saltier during 1975 to 1995,and freshen again from 1995 to 2010.The strongest anomalies appear in the northeastern,northern,and northwestern regions in the three periods,respectively.The salinity variation trends become weaker below the upper layer,except the salinifi cation trend in the northern SCS extends to at least 300 m during the salinifi cation period.Diagnosis of the salinity budget over the top 100 m shows that during the fi rst freshening period horizontal advection,vertical advection,and surface freshwater forcing all contribute to salinity freshening,and horizontal advection is relatively larger.The contribution of horizontal advection and surface freshwater forcing to the positive salinity anomaly is comparable,while the vertical advection is the secondary factor in the salinifi cation period.Horizontal advection,especially zonal advection,plays a crucial role during the second freshening period.Moreover,horizontal advection is more important than that in the fi rst freshening period.In addition,the contribution of horizontal advection is mainly in zonal direction controlled by Kuroshio intrusion.Further analysis shows the upper-layer salinity variations have a Pacifi c Decadal Oscillation(PDO)-like signal,with freshening during the negative PDO years,and salinifi cation during the positive PDO years.PDO mainly infl uences the upper-layer salinity changes through both atmospheric bridge and oceanic bridge.

Physical structure and phytoplankton community off the eastern Hainan coast during summer 2015

Based on satellite remote sensing dataset and survey data during upwelling season of 2015,the spatial structures of phytoplankton biomass and community for the first time in the eastern Hainan upwelling(EHU)and its adjacent area,the eastern Leizhou Peninsula upwelling(ELPU)were illustrated.It is found that a significant cold tongue with high salinity and low temperature along the eastern Hainan coast driven by upwelling-favorable summer monsoon.The ELPU was relative weaker than the EHU because of its wide and gentle continental slope.Due to mixing by tides and waves,DO concentration with high value(>6.0 mg/L)were almost homogenous from surface to 30 m depth at the EHU.Beneath that,low DO water(<6.0 mg/L,anoxia)were pumped upward from bottom by the upwelling.The ELPU has worse DO condition compared with the EHU where bottom DO were lower than 3.5 mg/L owing to abundant DO consumption.The phytoplankton biomass reached maximal value about 1.5 mg/m3 at 30 m depth layer rather than surface layer at the EHU indicating the impact limit of upwelling on phytoplankton growth and DO distribution.Nourished by rich nutrient input,the phytoplankton biomass at the ELPU were much higher than the EHU where the maximal value can reach about 4.0 mg/m3.The phytoplankton biomass were reduced to about 0.2–0.3 mg/m3 at the offshore areas of the EHU and ELPU which were close to the value at open sea.At the inshore of the EHU,the phytoplankton community was dominated by diatom which accounted for about 50%of phytoplankton biomass.And prokaryotes(about 40%),green algae(about 20%)and prochlorococcus(about 20%)became main species at the offshore of the EHU.At the ELPU,diatom accounted for about 80%of phytoplankton biomass followed by green algae,indicating a different ecosystem at this region compared with the EHU.

Low lattice thermal conductivity and high figure of merit in p-type doped K3IO

Based on first-principles calculations, Boltzmann transport equation and semiclassical analysis, we conduct a detailed study on the lattice thermal conductivity κL, Seebeck coefficient S, electrical conductivity σ, power factor S2σ and dimensionless figure of merit, zT, for K3IO. It is found that K3IO exhibits relatively low lattice thermal conductivity of 0.93 W·m-1·K-1 at 300 K, which is lower than the value 1.26 W·m-1·K-1 of the classical TE material PbTe. This is due to the smaller phonon group velocity νg and smaller relaxation time τλ. The low lattice thermal conductivity can lead to excellent thermoelectric properties. Thus maximum zT of 2.87 is obtained at 700 K, and the zT = 0.41 at 300 K indicate that K3IO is a potential excellent room temperature TE material. Our research on K3IO shows that it has excellent thermoelectric properties, and it is a promising candidate for applications in fields in terms of thermoelectricity.

A new presentation of the Indian Ocean shallow overturning circulation from a vertical perspective

由于印尼贯穿流干扰了南印度洋经向翻转环流的计算,本文应用垂向翻转流函数来诊断印度洋浅层经向翻转环流.基于海洋环流模拟产品(OFES),本文探讨了垂向流函数相比经向翻转流函数的改进.研究结果表明垂向翻转流函数能平滑连接南北印度洋的翻转环流,包括完整的副热带翻转环流和跨赤道翻转环流.经向翻转流函数低估了印度洋浅层翻转环流;而垂向翻转流函数表示的印度洋浅层翻转环流受印尼贯穿流影响更小,其评估的印度洋浅层翻转环流强度约13 Sv,其中副热带翻转环流强度约8 Sv(1 Sv≡10~6m~3S~(-1)).此外,垂向翻转流函数在印度洋南开边界(30°S~34°S)上600 m层表现为顺时针翻转结构,其强度约-5 Sv,可能对应风驱的副热带流系.因此,垂向翻转流函数提供了一种新方法来评估印度洋浅层翻转环流.

Scalable parallel ultrafast optical random bit generation based on a single chaotic microcomb

Random bit generators are critical for information security,cryptography,stochastic modeling,and simulations.Speed and scalability are key challenges faced by current physical random bit generation.Herein,we propose a massively parallel scheme for ultrafast random bit generation towards rates of order 100 terabit per second based on a single micro-ring resonator.A modulation-instability-driven chaotic comb in a micro-ring resonator enables the simultaneous generation of hundreds of independent and unbiased random bit streams.A proof-of-concept experiment demonstrates that using our method,random bit streams beyond 2 terabit per second can be successfully generated with only 7 comb lines.This bit rate can be easily enhanced by further increasing the number of comb lines used.Our approach provides a chip-scale solution to random bit generation for secure communication and high-performance computation,and offers superhigh speed and large scalability.

Hyperbolic resonant radiation of concomitant microcombs induced by cross-phase modulation

A high-quality optical microcavity can enhance optical nonlinear effects by resonant recirculation,which provides a reliable platform for nonlinear optics research.When a soliton microcomb and a probe optical field are coexisting in a micro-resonator,a concomitant microcomb(CMC)induced by cross-phase modulation(XPM)will be formed synchronously.Here,we characterize the CMC comprehensively in a micro-resonator through theory,numerical simulation,and experimental verification.It is found that the CMCs spectra are modulated due to resonant radiation(RR)resulting from the interaction of dispersion and XPM effects.The group velocity dispersion induces symmetric RRs on the CMC,which leads to a symmetric spectral envelope and a dual-peak pulse in frequency and temporal domains,respectively,while the group velocity mismatch breaks the symmetry of RRs and leads to asymmetric spectral and temporal profiles.When the group velocity is linearly varying with frequency,two RR frequencies are hyperbolically distributed about the pump,and the probe light acts as one of the asymptotic lines.Our results enrich the CMC dynamics and guide microcomb design and applications such as spectral extension and dark pulse generation.

Long-distance ranging with high precision using a soliton microcomb

Laser-based light detection and ranging(lidar)plays a significant role in both scientific and industrial areas.However,it is difficult for existing lidars to achieve high speed,high precision,and long distance simultaneously.Here,we demonstrate a high-performance lidar based on a chip-scaled soliton microcomb(SMC)that can realize all three specialties simultaneously.Aided by the excellent properties of ultrahigh repetition rate and the smooth envelope of the SMC,traditional optical frequency comb(OFC)-based dispersive interferometry is heavily improved and the measuring dead zone induced by the mismatch between the repetition rate of the OFC and resolution of the optical spectrum analyzer is totally eliminated.Combined with an auxiliary dual-frequency phase-modulated laser range finder,the none-dead-zone measurable range ambiguity is extended up to 1500 m.The proposed SMC lidar is experimentally implemented in both indoor and outdoor environment.In the outdoor baseline field,real-time,high-speed(up to 35 k Hz)measurement of a long distance of^1179 m is achieved with a minimum Allan deviation of 5.6μm at an average time of 0.2 ms(27 nm at an average time of 1.8 s after high-pass filtering).The present SMC lidar approaches a compact,fast,high-precision,and none-dead zone long-distance ranging system,aimed at emerging applications of frontier basic scientific research and advances in industrial manufacturing.

Multi-scale variability of the tropical Indian Ocean circulation system revealed by recent observations

The tropical Indian Ocean circulation system includes the equatorial and near-equatorial circulations, the marginal sea circulation, and eddies. The dynamic processes of these circulation systems show significant multi-scale variability associated with the Indian Monsoon and the Indian Ocean dipole. This paper summarizes the research progress over recent years on the tropical Indian Ocean circulation system based on the large-scale hydrological observations and numerical simulations by the South China Sea Institute of Oceanology(SCSIO), Chinese Academy of Sciences. Results show that:(1) the wind-driven Kelvin and Rossby waves and eastern boundary-reflected Rossby waves regulate the formation and evolution of the Equatorial Undercurrent and the Equatorial Intermediate Current;(2) the equatorial wind-driven dynamics are the main factor controlling the inter-annual variability of the thermocline in the eastern Indian Ocean upwelling;(3) the equatorial waves transport large amounts of energy into the Bay of Bengal in forms of coastal Kelvin and reflected free Rossby waves. Several unresolved issues within the tropical Indian Ocean are discussed:(i) the potential effects of the momentum balance and the basin resonance on the variability of the equatorial circulation system, and(ii) the potential contribution of wind-driven dynamics to the life cycle of the eastern Indian Ocean upwelling. This paper also briefly introduces the international Indian Ocean investigation project of the SCSIO, which will advance the study of the multi-scale variability of the tropical Indian Ocean circulation system, and provide a theoretical and data basis to support marine environmental security for the countries around the Maritime Silk Road.

Advances in soliton microcomb generation

Optical frequency combs,a revolutionary light source characterized by discrete and equally spaced frequencies,are usually regarded as a cornerstone for advanced frequency metrology,precision spectroscopy,high-speed communication,distance ranging,molecule detection,and many others.Due to the rapid development of micro/nanofabrication technology,breakthroughs in the quality factor of microresonators enable ultrahigh energy buildup inside cavities,which gives birth to microcavity-based frequency combs.In particular,the full coherent spectrum of the soliton microcomb(SMC)provides a route to low-noise ultrashort pulses with a repetition rate over two orders of magnitude higher than that of traditional mode-locking approaches.This enables lower power consumption and cost for a wide range of applications.This review summarizes recent achievements in SMCs,including the basic theory and physical model,as well as experimental techniques for single-soliton generation and various extraordinary soliton states(soliton crystals,Stokes solitons,breathers,molecules,cavity solitons,and dark solitons),with a perspective on their potential applications and remaining challenges.

Genetic-algorithm-based deep neural networks for highly efficient photonic device design

While deep learning has demonstrated tremendous potential for photonic device design,it often demands a large amount of labeled data to train these deep neural network models.Preparing these data requires high-resolution numerical simulations or experimental measurements and cost significant,if not prohibitive,time and resources.In this work,we present a highly efficient inverse design method that combines deep neural networks with a genetic algorithm to optimize the geometry of photonic devices in the polar coordinate system.The method requires significantly less training data compared with previous inverse design methods.We implement this method to design several ultra-compact silicon photonics devices with challenging properties including power splitters with uncommon splitting ratios,a TE mode converter,and a broadband power splitter.These devices are free of the features beyond the capability of photolithography and generally in compliance with silicon photonics fabrication design rules.

Influences of multiphoton absorption and freecarrier effects on frequency-comb generation in normal dispersion silicon microresonators

We investigate frequency-comb generation in normal dispersion silicon microresonators from the near-infrared to mid-infrared wavelength range in the presence of multiphoton absorption and free-carrier effects. It is found that parametric oscillation is inhibited in the telecom wavelength range resulting from strong two-photon absorption.On the contrary, beyond the wavelength of 2200 nm, where three-and four-photon absorption are less detrimental,a comb can be generated with moderate pump power, or free-carriers are swept out by a positive-intrinsic-negative structure. In the temporal domain, the generated combs correspond to flat-top pulses, and the pulse duration can be easily controlled by varying the laser detuning. The reported comb generation process shows a high conversion efficiency compared with anomalous dispersion regime, which can guide and promote comb formation in materials with normal dispersion. As the comb spectra cover the mid-infrared wavelength range, they can find applications in comb-based radiofrequency photonic filters and mid-infrared spectroscopy.

Program-controlled single soliton microcomb source

Soliton microcombs(SMCs)are spontaneously formed in a coherently pumped high-quality microresonator,which provides a new tool for use as an on-chip frequency comb for applications of high-precision metrology and spectroscopy.However,generation of SMCs seriously relies on advanced experimental techniques from professional scientists.Here,we experimentally demonstrate a program-controlled single SMC source where the intracavity thermal effect is timely balanced using an auxiliary laser during single SMC generation.The microcomb power is adopted as the criteria for microcomb states discrimination and a forward and backward thermal tuning technique is employed for the deterministic single SMC generation.Further,based on a closed-loop control system,the repetition rate stability of the SMC source improved more than 20 times and the pump frequency can be continuously tuned by simply changing the operation temperature.The reliability of the SMC source is verified by consecutive 200 generation trials and maintaining over 10 h.We believe the proposed SMC source will have significant promising influences in future SMC-based application development.