An analysis of Thalassinoides ichnofabrics in the Cambrian Stage 4 Longwangmiao Formation from six sections near Chonqing in the Middle and Upper Yangtze Block of South China was conducted to promote the understanding...An analysis of Thalassinoides ichnofabrics in the Cambrian Stage 4 Longwangmiao Formation from six sections near Chonqing in the Middle and Upper Yangtze Block of South China was conducted to promote the understanding of the paleoenvironment of this period.Thalassinoides ichnofabrics are divided into three types according to their morphology,bioturbation index,abundance and related parameters:banded,mottled and grid.The completeness of the ichnofabrics gradually increases from banded to grid,the scale of the burrows expands,and the structure transitions from twodimensional to three-dimensional.Malacostracans,phyllocarids and enteropneusts are the most likely burrowers.The findings reveal that frequent changes in paleoenvironmental conditions are the dominant factors for generating the various Thalassinoides ichnofabrics.The changes in depositional rate,substrate properties and nutrient levels affect the behavior and building patterns of the burrowers,thus leading to the diversity of Thalassinoides ichnofabrics.In the lower Longwangmiao Formation beds,many incomplete Thalassinoides burrow systems were built in the substrates with terrigenous detrital minerals,revealing significant environmental pressure on the burrowers.Later,the Thalassinoides burrows went into complete three-dimensional boxworks.At the end of the stage,bioturbation almost disappeared,which indicates that burrowers were finding it difficult to survive in the harsh environment.展开更多
The mechanisms causing quality variations and key control factors of submarine-fan reservoirs in the gas field X of the Rovuma Basin,East Africa are analyzed based on core and well-log data in this paper.Depositional ...The mechanisms causing quality variations and key control factors of submarine-fan reservoirs in the gas field X of the Rovuma Basin,East Africa are analyzed based on core and well-log data in this paper.Depositional fabric,lithofacies difference and characteristics of genetic units are the fundamental reasons of reservoir quality variations.In the case of weak cementation,porosity and permeability of submarine-fan reservoirs are controlled by grain sorting and clay content,respectively.Reservoir quality variations for 5 main lithofacies are related to variable depositional fabrics and calcite cementation.Among them,massive medium-coarse sandstones with weak cementation have the highest porosity and permeability,and coarser or finer sandstones have poorer reservoir quality.The existence of bottom current can develop laminated sandstones,improving the pore structure and physical properties greatly.Lithofacies vary among different types,locations and stages of genetic units,and they control the distribution patterns of submarine-fan reservoir quality:the physical properties of channel shaft or lobe main body are better than those of the channel or lobe edge.The sandstone sorting and physical properties are gradually improved from near-source to far-source.When multi-stage sand bodies are superimposed,the sand-mud ratio in the later stage is higher than that in the earlier stage,making the physical properties get better in the later stage.展开更多
In the context of non-alcoholic fatty liver disease (NAFLD), characterized by dysregulated lipid metabolism in hepatocytes, the quest for safe and effective therapeutics targeting lipid metabolism has gained paramount...In the context of non-alcoholic fatty liver disease (NAFLD), characterized by dysregulated lipid metabolism in hepatocytes, the quest for safe and effective therapeutics targeting lipid metabolism has gained paramount importance. Sanhuang Xiexin Tang (SXT) and Baihu Tang (BHT) have emerged as prominent candidates for treating metabolic disorders. SXT combined with BHT plus Cangzhu (SBC) has been used clinically for Weihuochisheng obese patients. This retrospective analysis focused on assessing the anti-obesity effects of SBC in Weihuochisheng obese patients. We observed significant reductions in body weight and hepatic lipid content among obese patients following SBC treatment. To gain further insights, we investigated the effects and underlying mechanisms of SBC in HFD-fed mice. The results demonstrated that SBC treatment mitigated body weight gain and hepatic lipid accumulation in HFD-fed mice. Pharmacological network analysis suggested that SBC may affect lipid metabolism, mitochondria, inflammation, and apoptosis—a hypothesis supported by the hepatic transcriptomic analysis in HFD-fed mice treated with SBC. Notably, SBC treatment was associated with enhanced hepatic mitochondrial biogenesis and the inhibition of the c-Jun N-terminal kinase (JNK)/nuclear factor-kappa B (NF-κB) and extracellular signal-regulated kinase (ERK)/NF-κB pathways. In conclusion, SBC treatment alleviates NAFLD in both obese patients and mouse models by improving lipid metabolism, potentially through enhancing mitochondrial biogenesis. These effects, in turn, ameliorate inflammation in hepatocytes.展开更多
基金financially supported by the National Key Science and Technology Planning Project(2016ZX05007–004 and 2017ZX05001001–002)。
文摘An analysis of Thalassinoides ichnofabrics in the Cambrian Stage 4 Longwangmiao Formation from six sections near Chonqing in the Middle and Upper Yangtze Block of South China was conducted to promote the understanding of the paleoenvironment of this period.Thalassinoides ichnofabrics are divided into three types according to their morphology,bioturbation index,abundance and related parameters:banded,mottled and grid.The completeness of the ichnofabrics gradually increases from banded to grid,the scale of the burrows expands,and the structure transitions from twodimensional to three-dimensional.Malacostracans,phyllocarids and enteropneusts are the most likely burrowers.The findings reveal that frequent changes in paleoenvironmental conditions are the dominant factors for generating the various Thalassinoides ichnofabrics.The changes in depositional rate,substrate properties and nutrient levels affect the behavior and building patterns of the burrowers,thus leading to the diversity of Thalassinoides ichnofabrics.In the lower Longwangmiao Formation beds,many incomplete Thalassinoides burrow systems were built in the substrates with terrigenous detrital minerals,revealing significant environmental pressure on the burrowers.Later,the Thalassinoides burrows went into complete three-dimensional boxworks.At the end of the stage,bioturbation almost disappeared,which indicates that burrowers were finding it difficult to survive in the harsh environment.
文摘The mechanisms causing quality variations and key control factors of submarine-fan reservoirs in the gas field X of the Rovuma Basin,East Africa are analyzed based on core and well-log data in this paper.Depositional fabric,lithofacies difference and characteristics of genetic units are the fundamental reasons of reservoir quality variations.In the case of weak cementation,porosity and permeability of submarine-fan reservoirs are controlled by grain sorting and clay content,respectively.Reservoir quality variations for 5 main lithofacies are related to variable depositional fabrics and calcite cementation.Among them,massive medium-coarse sandstones with weak cementation have the highest porosity and permeability,and coarser or finer sandstones have poorer reservoir quality.The existence of bottom current can develop laminated sandstones,improving the pore structure and physical properties greatly.Lithofacies vary among different types,locations and stages of genetic units,and they control the distribution patterns of submarine-fan reservoir quality:the physical properties of channel shaft or lobe main body are better than those of the channel or lobe edge.The sandstone sorting and physical properties are gradually improved from near-source to far-source.When multi-stage sand bodies are superimposed,the sand-mud ratio in the later stage is higher than that in the earlier stage,making the physical properties get better in the later stage.
基金supported by grants from the National Key R&D Program of China(2017YFA0105803)the National Natural Science Foundation of China(82270886,82070811)+2 种基金the Science and Technology Plan Project of Guangzhou City(202007040003,202201020497)the 5010 Clinical Research Projects of Sun Yat-Sen University(2015015)the Dengfeng Plan High-level Hospital Construction Opening Project of Foshan Fourth People's Hospital(FSSYKF-2020011 and FSSYKF-2020009)。
文摘In the context of non-alcoholic fatty liver disease (NAFLD), characterized by dysregulated lipid metabolism in hepatocytes, the quest for safe and effective therapeutics targeting lipid metabolism has gained paramount importance. Sanhuang Xiexin Tang (SXT) and Baihu Tang (BHT) have emerged as prominent candidates for treating metabolic disorders. SXT combined with BHT plus Cangzhu (SBC) has been used clinically for Weihuochisheng obese patients. This retrospective analysis focused on assessing the anti-obesity effects of SBC in Weihuochisheng obese patients. We observed significant reductions in body weight and hepatic lipid content among obese patients following SBC treatment. To gain further insights, we investigated the effects and underlying mechanisms of SBC in HFD-fed mice. The results demonstrated that SBC treatment mitigated body weight gain and hepatic lipid accumulation in HFD-fed mice. Pharmacological network analysis suggested that SBC may affect lipid metabolism, mitochondria, inflammation, and apoptosis—a hypothesis supported by the hepatic transcriptomic analysis in HFD-fed mice treated with SBC. Notably, SBC treatment was associated with enhanced hepatic mitochondrial biogenesis and the inhibition of the c-Jun N-terminal kinase (JNK)/nuclear factor-kappa B (NF-κB) and extracellular signal-regulated kinase (ERK)/NF-κB pathways. In conclusion, SBC treatment alleviates NAFLD in both obese patients and mouse models by improving lipid metabolism, potentially through enhancing mitochondrial biogenesis. These effects, in turn, ameliorate inflammation in hepatocytes.
