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FGF-receptor substrate 2 functions as a molecular sensor ntegrating external regulatory signals into the FGF pathway 被引量:2
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作者 wenchao zhou Xiujing Feng +3 位作者 Yingjie Wu Johannes Benge Zhe Zhang Zhengjun Chen 《Cell Research》 SCIE CAS CSCD 2009年第10期1165-1177,共13页
(FRS2 ) 成纤维细胞生长因素(FGF ) 受体底层 2 是在 FGF 小径发信号的主要调停人。最近的研究在 FRS2 显示出那激活 mitogen 的蛋白质 kinase (MAPK ) phosphorylates 丝氨酸和 threonine 残余,否定地影响 FRS2 的导致 FGF 的酷氨酸 p... (FRS2 ) 成纤维细胞生长因素(FGF ) 受体底层 2 是在 FGF 小径发信号的主要调停人。最近的研究在 FRS2 显示出那激活 mitogen 的蛋白质 kinase (MAPK ) phosphorylates 丝氨酸和 threonine 残余,否定地影响 FRS2 的导致 FGF 的酷氨酸 phosphorylation (PY ) 。几种刺激能导致 FRS2 的 serine/threonine phosphorylation (PS/T ) ,显示 FRS2 可能为学习在表明小径的生长因素之间的串音是有用的。这里,我们报导 FRS2 的导致 FGF 的 PY 能被 EGF 合作刺激在 PC12 房间稀释;这禁止的效果能被 U0126 完全颠倒, MEK 的一个禁止者。我们进一步在 FRS2 识别了 ERK1/2-binding 主题并且在 FGF 或 EGF 刺激之上产生了 FRS2-3KL,变异的缺乏 MAPK 绑定和磅。不同野类型(WT ) FRS2, FRS2-3KL 的导致 FGF 的 PY 不能被 EGF 合作刺激,和更展出的 FRS2-3KL-expressing PC12 房间禁止响应 FGF 处理比 FRS2-WT-expressing 房间区分潜力。这些结果建议 FRS2 的 PS/T 由 FRS2-MAPK 否定规章的循环调停了可以作为从另外的小径把否定规章的信号集成到产生 FGFR 的信号 transduction 的一个分子的开关工作。 展开更多
关键词 生长因子受体 信号通路 丝裂原活化蛋白激酶 监管职能 成纤维细胞生长因子 分子 底物 传感器
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Soliton frequency comb generation in CMOS-compatible silicon nitride microresonators 被引量:3
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作者 YAOZU XIE JIAQI LI +7 位作者 YANFENG ZHANG ZERU WU SHIHAO ZENG SHUQING LIN ZHAOYANG WU wenchao zhou YUJIE CHEN SIYUAN YU 《Photonics Research》 SCIE EI CAS CSCD 2022年第5期1290-1296,共7页
The monolithic integration of soliton microcomb devices with active photonic components and high-frequency electronics is highly desirable for practical applications. Among many materials, silicon nitride(SiN_(x)) wav... The monolithic integration of soliton microcomb devices with active photonic components and high-frequency electronics is highly desirable for practical applications. Among many materials, silicon nitride(SiN_(x)) waveguide layers prepared by low-pressure chemical vapor deposition(LPCVD) have been the main platform for on-chip optical frequency comb generation. However, the high temperatures involved in LPCVD render it incompatible as a back-end process with complementary metal oxide semiconductor(CMOS) or active Ⅲ-Ⅴ compound semiconductor fabrication flows. We report the generation of coherent soliton frequency combs in micro-ring resonators fabricated in deuterated silicon nitride(SiN_(x):D) waveguides with a loss of 0.09 d B/cm. Deposited at 270℃ by an inductance-coupled plasma chemical vapor deposition(ICP-CVD) process, the material preparation and fabrication flow are fully CMOS-compatible. These results enable the integration of silicon-nitride-based optical combs and photonic integrated circuits(PICs) on prefabricated CMOS and/or Ⅲ-Ⅴ substrates, therefore marking a major step forward in Si Nxphotonic technologies. 展开更多
关键词 LPCVD WAVEGUIDE SOLITON
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THEORETICAL INVESTIGATION ON THE DYNAMIC PERFORMANCE OF CMUT FOR DESIGN OPTIMIZATION 被引量:3
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作者 Ting Yu wenchao zhou +2 位作者 Peng Xu Fengqi Yu Qin Qian 《Acta Mechanica Solida Sinica》 SCIE EI CSCD 2013年第1期99-110,共12页
Although many modeling approaches exist for analyzing the behavior of capacitive micro-machined ultrasonic transducers (CMUTs), the relation equation between the design pa- rameters with input and output is still la... Although many modeling approaches exist for analyzing the behavior of capacitive micro-machined ultrasonic transducers (CMUTs), the relation equation between the design pa- rameters with input and output is still lacking. What there is can only be used to analyze the dynamic performance of CMUT indirectly and qualitatively, such as stiffness and sound pressure. A lumped-parameter theoretical model based on the dynamic theory is proposed in this paper. The relation equations between the design parameters with inputs and outputs are given. The results obtained by the proposed model agree well with those by finite element method (FEM) simulation. The dynamic and static behavior of CMUT can be clearly depicted, which is helpful for design and optimization iterations. This shows that the proposed model makes it easier to optimize the parameters of a CMUT with respect to output and bandwidth directly and to better understand the influence of each parameter. 展开更多
关键词 CMUT dynamic theory finite element method
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