B超辅助诊断乳腺癌的Meta分析

目的:评估超声辅助诊断乳腺癌的临床价值。方法:以"B超"和"乳腺癌"为关键词,检索中国生物医学文献数据库(CBM)和中国知网(CNKI),查找我国2011-01~2016-12发表的应用乳腺B超辅助诊断乳腺癌的相关研究文献。由2位评价员按照纳入与排除标准独立筛选文献、提取资料和评价纳入研究的方法学质量后,采用Stata 13.1软件进行Meta分析。结果:最终纳入19篇中文文献。Meta分析结果显示,SEN_(合并)=0.84[95%CI(0.79-0.88)],+LR=3.8[95%CI(2.4-6.0)];SPE_(合并)=0.78[95%CI(0.66-0.86)],-LR=0.21[95%CI(0.15-0.28)];DOC_(合并)=19[9,36];AUC=0.88[0.85-0.91]。结论:B超辅助诊断乳腺癌具有较好的临床价值,但结论尚需高质量的前瞻性研究进一步验证。

蒙药蓝盆花对大鼠急性肝损伤的保护作用研究

目的:研究蒙药兰盆花对大鼠急性肝损伤的保护作用.方法:将实验大鼠随机分为正常对照组、急性肝损伤模型组、阳性药物组和蓝盆花低、中、高剂量组.空白组与模型组动物均灌胃蒸馏水(1次/d,14d),阳性药物组和蓝盆花低、中、高剂量组均按实验剂量连续灌胃给药(1次/d,14d).末次给药后腹腔注射D-氨基半乳糖/脂多糖(300mg·kg^-1/0.1mg·kg^-1),6h后取血,测定实验大鼠血清中与肝脏功能损伤相关指标及炎性因子的变化情况.结果:模型组大鼠血清中肝脏功能指标ALT、AST和TBA水平升高;炎症因子指标肿瘤坏死因子α(TNF-α)、白介素-6(IL-6)水平升高,白介素-10(IL-10)水平降低.给予蓝盆花可显著改善肝功能,表现出一定的抗炎作用,可以降低ALT、AST、TBA、TNF-α和IL-6的水平,升高IL-10的水平,缓解由D-氨基半乳糖联合脂多糖引起的急性肝损伤.结论:蓝盆花对D-氨基半乳糖联合脂多糖所致大鼠急性肝功能损伤有保护作用.

Injector Nozzle Flow Model and Its Effects on the Calculations of High Pressure Sprays

This paper discusses the flowing process inside a nozzle, especially the formation mechanism of cavitations within the nozzle and puts forward a nozzle flow model, which takes account of the injection conditions and nozzle geometry. By the model being implemented to the KIVA codes, the spray characteristics (e. g., spray penetration and cone angle) of diesel and dimethyl ether (DME) are simulated. The comparisons between the computational and experimental results are performed, which show that the liquid spray characteristics could be more truly demonstrated by considering the existence of the cavitations. Key words nozzle model - spray characteristics - cavitation - atomization CLC number O 35 - TK 402 Foundation item: Supported by the National Natural Science Foundation of China (50376018) and the National 973 Basic Research Program of China (2001CB209207)Biography: WEI Ming-rui (1967-), male, Associate professor, Ph. D, research direction: computational combustion, computational fluid dynamics.