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新辅助化疗对不同分子亚型乳腺癌免疫标记表达的影响 被引量:5
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作者 沈方媛 曾斌 +1 位作者 吴慧 杨露 《暨南大学学报(自然科学与医学版)》 CAS CSCD 北大核心 2018年第3期229-235,共7页
目的:分析不同分子亚型乳腺癌患者新辅助化疗后临床病理缓解及免疫标记表达变化情况,探讨这些指标变化的临床意义及与新辅助化疗疗效的相关性.方法:收集221例接受蒽环类联合紫杉类药物新辅助化疗并成功施行手术的乳腺癌患者,通过S-P免... 目的:分析不同分子亚型乳腺癌患者新辅助化疗后临床病理缓解及免疫标记表达变化情况,探讨这些指标变化的临床意义及与新辅助化疗疗效的相关性.方法:收集221例接受蒽环类联合紫杉类药物新辅助化疗并成功施行手术的乳腺癌患者,通过S-P免疫组化检测对比新辅助化疗前后雌激素受体(ER)、孕激素受体(PR)、人类表皮生长因子受体2(HER-2)及细胞增殖抗原(Ki-67)的表达情况.结果:在221例乳腺癌患者中,Luminal A型的临床有效缓解率(CR+PR)低于其他3组病例(P=0.037),三阴性(17.54%)及Her-2过表达型(25.64%)的病理完全缓解率(p CR)明显高于Luminal A型(7.14%)及Luminal B型(7.23%).新辅助化疗后不同分子亚型乳腺癌患者的ki-67的下降是有差异的(P=0.04)且Ki-67的变化与新辅助化疗的疗效相关联(CR+PR)(P=0.000),而ER、PR、Her-2受体状态的变化无统计学差异(P>0.05).结论:新辅助化疗可以明显降低Ki-67的表达且与分子分型密切相关,但对ER、PR及Her-2表达的影响甚微.Ki-67可作为新辅助化疗疗效的预测指标. 展开更多
关键词 乳腺癌 分子亚型 新辅助化疗 化疗疗效 免疫组化
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Relationship between a function of the northward pressure gradient and the Pacific Equatorial Undercurrent
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作者 CHEN Xuan ZHENG Chongwei +3 位作者 wu hui YOU Xiaobao LI Xunqiang WANG huipeng 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2018年第9期22-28,共7页
The Equatorial Undercurrent(EUC) plays an important role in ocean circulation and global climate change. Near the equator, as the Coriolis parameter goes to 0, equatorial currents cannot be described by geostrophy i... The Equatorial Undercurrent(EUC) plays an important role in ocean circulation and global climate change. Near the equator, as the Coriolis parameter goes to 0, equatorial currents cannot be described by geostrophy in which the pressure gradient force term is balanced by the Coriolis force term. Many previous studies focus on the relationships between the EUC and El Ni?o-Southern Oscillation(ENSO), the thermocline, sea surface topography, the distribution of equatorial wind stress and other atmosphere-ocean factors. However, little attention has been paid to the northward pressure gradient(NGT), which may also be important to the EUC. The pressure can be regarded as a complex nonlinear function of terms including temperature, salinity and density.This study attempts to reveal the connection between a function of the northward pressure gradient(FNP) and the EUC. The connection is derived from primitive equations, by simplifying the equations with using scaling analysis, and shows that the beta effect may be the main reason why the FNP is important to the EUC. The vertical structure of the EUC can be partially described by the FNP. The NGT has an obvious influence on the EUC while the eastward pressure gradient has a relatively smaller effect. 展开更多
关键词 EQUATORIAL Undercurrent northward pressure gradient beta effect
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