急危重症目前仍是全球面临的一个重大问题,病情凶险,预后极差。C反应蛋白与白蛋白比值(C-reactive protein to albumin ratio,CAR)近年来被发现在急危重症领域有突出价值。本文就近十年CAR在急危重症领域的相关文献以病理生理学机制为...急危重症目前仍是全球面临的一个重大问题,病情凶险,预后极差。C反应蛋白与白蛋白比值(C-reactive protein to albumin ratio,CAR)近年来被发现在急危重症领域有突出价值。本文就近十年CAR在急危重症领域的相关文献以病理生理学机制为切入点,在阐述既往研究的基础上,梳理CAR在急危重症领域最新研究成果,着重对脓毒症、新型冠状病毒感染等常见急危重症患者的预后进行对比阐述,明确优势与不足,以期为临床工作者对急危重症患者的监测提供新的临床思路及理论依据。展开更多
Objective： To investigate the effects of Shenfu Injection （参附注射液, SFI） on cerebral metabolism in a porcine model of cardiac arrest （CA）. Methods： Thirty Wuzhishan minipigs were randomly assigned to the cont...Objective： To investigate the effects of Shenfu Injection （参附注射液, SFI） on cerebral metabolism in a porcine model of cardiac arrest （CA）. Methods： Thirty Wuzhishan minipigs were randomly assigned to the control group （n=6）, epinephrine group （Fp group, n=12） and SFI group （n=12）. After 8 min of untreated ventricular fibrillation （VF）, pigs in the EP group or SFI group were administered with either i=p （0.02 mg/kg） or SFI （1.0 mL/kg）, respectively. After successful resuscitation, cerebrospinal fluid （CSF） levels of glucose, pyruvate, lactate, glutamate and glycerol were measured at 1, 6, 12 and 24 h after recover from spontaneous circulation （ROSC）. In addition, neurologic deficit score （NDS） was calculated at 24 h after ROSC. Surviving pigs were killed at 24 h after ROSC, and the brain tissue was obtained for ultra-microstructure examination. Results： Compared with the EP group, CSF glucose and pyruvate levels were higher （all P〈0.01）, and lactate levels were lower in the SFI group （P〈0.01）. Meanwhile, CSF glutamate and glycerol levels in the SFI group were lower in comparison to the EP group （all P〈0.05）. In addition, SFI decreased NDS at 24 h after ROSC （P〈0.01）, and alleviated the histopathological damage of the brain. Conclusions： SFI could alleviate brain injury after CA, which may be associated with improving cerebral metabolism.展开更多
文摘急危重症目前仍是全球面临的一个重大问题,病情凶险,预后极差。C反应蛋白与白蛋白比值(C-reactive protein to albumin ratio,CAR)近年来被发现在急危重症领域有突出价值。本文就近十年CAR在急危重症领域的相关文献以病理生理学机制为切入点,在阐述既往研究的基础上,梳理CAR在急危重症领域最新研究成果,着重对脓毒症、新型冠状病毒感染等常见急危重症患者的预后进行对比阐述,明确优势与不足,以期为临床工作者对急危重症患者的监测提供新的临床思路及理论依据。
文摘Objective： To investigate the effects of Shenfu Injection （参附注射液, SFI） on cerebral metabolism in a porcine model of cardiac arrest （CA）. Methods： Thirty Wuzhishan minipigs were randomly assigned to the control group （n=6）, epinephrine group （Fp group, n=12） and SFI group （n=12）. After 8 min of untreated ventricular fibrillation （VF）, pigs in the EP group or SFI group were administered with either i=p （0.02 mg/kg） or SFI （1.0 mL/kg）, respectively. After successful resuscitation, cerebrospinal fluid （CSF） levels of glucose, pyruvate, lactate, glutamate and glycerol were measured at 1, 6, 12 and 24 h after recover from spontaneous circulation （ROSC）. In addition, neurologic deficit score （NDS） was calculated at 24 h after ROSC. Surviving pigs were killed at 24 h after ROSC, and the brain tissue was obtained for ultra-microstructure examination. Results： Compared with the EP group, CSF glucose and pyruvate levels were higher （all P〈0.01）, and lactate levels were lower in the SFI group （P〈0.01）. Meanwhile, CSF glutamate and glycerol levels in the SFI group were lower in comparison to the EP group （all P〈0.05）. In addition, SFI decreased NDS at 24 h after ROSC （P〈0.01）, and alleviated the histopathological damage of the brain. Conclusions： SFI could alleviate brain injury after CA, which may be associated with improving cerebral metabolism.
