A group of small RNA molecules, distinct from but related to siRNAs （small interference RNAs） have been identified in a variety of organisms. These small RNAs, called microRNAs （miRNAs）, are endogenously encoded a...A group of small RNA molecules, distinct from but related to siRNAs （small interference RNAs） have been identified in a variety of organisms. These small RNAs, called microRNAs （miRNAs）, are endogenously encoded approximately 20-24 nt long single-stranded RNAs. They are generally expressed in a highly tissue- or developmental-stage-specific fashion and are post-transcriptional regulator of gene expression in animals and plants. This article summarizes the character, mechanism and analysis method about miRNAs. The current view that miRNAs represent a newly discovered, hidden layer of gene regulation has resulted in high interest among researchers in the discovery of miRNAs, their targets, expression mechanism of action and analysis methods.展开更多
文摘A group of small RNA molecules, distinct from but related to siRNAs （small interference RNAs） have been identified in a variety of organisms. These small RNAs, called microRNAs （miRNAs）, are endogenously encoded approximately 20-24 nt long single-stranded RNAs. They are generally expressed in a highly tissue- or developmental-stage-specific fashion and are post-transcriptional regulator of gene expression in animals and plants. This article summarizes the character, mechanism and analysis method about miRNAs. The current view that miRNAs represent a newly discovered, hidden layer of gene regulation has resulted in high interest among researchers in the discovery of miRNAs, their targets, expression mechanism of action and analysis methods.
