目的:研究社区康复治疗对“1+1+1”签约脑卒中患者及其家属生存质量和幸福感的影响。方法:将社区内37名“1+1+1”签约脑卒中患者及35名患者家属纳入研究,37名患者中有男性26例,女性11例,年龄42~89岁,平均年龄(71.08±10.17)岁;35名...目的:研究社区康复治疗对“1+1+1”签约脑卒中患者及其家属生存质量和幸福感的影响。方法:将社区内37名“1+1+1”签约脑卒中患者及35名患者家属纳入研究,37名患者中有男性26例,女性11例,年龄42~89岁,平均年龄(71.08±10.17)岁;35名患者家属中有男性11例,女性24例,年龄24~89岁,平均年龄(59.74±16.75)岁。社区康复治疗团队对患者进行6个月的康复治疗,用世界卫生组织与健康相关生存质量量表(WHO quality of life scale,WHOQOL)和总体幸福感量表(general well-being schedule,GWB)的评分评价社区康复治疗对“1+1+1”签约脑卒中患者及其家属生存质量和幸福感的影响。结果:社区康复治疗后,患者的WHOQOL评分及GWB评分均比治疗前有显著提高(均P<0.05),患者家属的WHOQOL评分及GWB评分均比治疗前也有显著提高(均P<0.05)。结论:社区康复治疗对提高脑卒中患者及其家属的生存质量和幸福感有积极作用。展开更多
In this study, the effects of lead ions(Pb^(2+)) on the conformations of leucine encephalin(LE) and methionine encephalin(ME) in gas phase were studied using hydrogen/deuterium exchange mass spectrometry(HDX-MS) and q...In this study, the effects of lead ions(Pb^(2+)) on the conformations of leucine encephalin(LE) and methionine encephalin(ME) in gas phase were studied using hydrogen/deuterium exchange mass spectrometry(HDX-MS) and quantum chemistry theoretical calculations at the molecular level. The HDX-MS result revealed that the complexes with the monovalent compounds [LE+Pb–H]+ and [ME+Pb–H]+had a 1:1 stoichiometric ratio, and different HDX reactivates were observed in a follow of [ME+H]+>[LE+H]+>[LE+Pb–H]+> [ME+Pb–H]+. Combining the collision-induced dissociation energies of the complexes and their HDX results, it was found that the more stable the complex, the harder it was for HDX. In addition, the favo-rable conformations of the complexes were obtained by theoretical calculations, revealing that the similar coordination type with diffe-rent bond lengths was obtained. Then, the proton affinity(PA) values of the optimized complexes were calculated to interpret the HDX observations, indicating that the higher the PA values, the more difficult it was for HDX. Overall, the experiments and theoretical calculations revealed that Pb^(2+) could induce conformational changes of LE and ME, and generate ME into a more rigid conformation than LE. The results will prompt further fundamental investigations on the conformational properties of LE/ME in coordination with Pb^(2+).展开更多
文摘目的:研究社区康复治疗对“1+1+1”签约脑卒中患者及其家属生存质量和幸福感的影响。方法:将社区内37名“1+1+1”签约脑卒中患者及35名患者家属纳入研究,37名患者中有男性26例,女性11例,年龄42~89岁,平均年龄(71.08±10.17)岁;35名患者家属中有男性11例,女性24例,年龄24~89岁,平均年龄(59.74±16.75)岁。社区康复治疗团队对患者进行6个月的康复治疗,用世界卫生组织与健康相关生存质量量表(WHO quality of life scale,WHOQOL)和总体幸福感量表(general well-being schedule,GWB)的评分评价社区康复治疗对“1+1+1”签约脑卒中患者及其家属生存质量和幸福感的影响。结果:社区康复治疗后,患者的WHOQOL评分及GWB评分均比治疗前有显著提高(均P<0.05),患者家属的WHOQOL评分及GWB评分均比治疗前也有显著提高(均P<0.05)。结论:社区康复治疗对提高脑卒中患者及其家属的生存质量和幸福感有积极作用。
基金supported by the National Natural Science Foundation of China (Nos.22004074,21927805,21803013 and 21773035)the Public Welfare Fund Project of Ningbo City,China(No.202002N3113)+1 种基金the National Key Research and Development Program of China(No.2020YFF01014601)the K.C.Wong Magna Fund in Ningbo University,China.
文摘In this study, the effects of lead ions(Pb^(2+)) on the conformations of leucine encephalin(LE) and methionine encephalin(ME) in gas phase were studied using hydrogen/deuterium exchange mass spectrometry(HDX-MS) and quantum chemistry theoretical calculations at the molecular level. The HDX-MS result revealed that the complexes with the monovalent compounds [LE+Pb–H]+ and [ME+Pb–H]+had a 1:1 stoichiometric ratio, and different HDX reactivates were observed in a follow of [ME+H]+>[LE+H]+>[LE+Pb–H]+> [ME+Pb–H]+. Combining the collision-induced dissociation energies of the complexes and their HDX results, it was found that the more stable the complex, the harder it was for HDX. In addition, the favo-rable conformations of the complexes were obtained by theoretical calculations, revealing that the similar coordination type with diffe-rent bond lengths was obtained. Then, the proton affinity(PA) values of the optimized complexes were calculated to interpret the HDX observations, indicating that the higher the PA values, the more difficult it was for HDX. Overall, the experiments and theoretical calculations revealed that Pb^(2+) could induce conformational changes of LE and ME, and generate ME into a more rigid conformation than LE. The results will prompt further fundamental investigations on the conformational properties of LE/ME in coordination with Pb^(2+).
