A new complex Mn(Htpc)2(H2O)2(1, Htpc = 5-(trifluoromethyl)pyridine-2-carboxylic acid) has been synthesized and characterized by elemental analysis, IR, TG and single-crystal X-ray diffraction. 1 belongs to triclinic ...A new complex Mn(Htpc)2(H2O)2(1, Htpc = 5-(trifluoromethyl)pyridine-2-carboxylic acid) has been synthesized and characterized by elemental analysis, IR, TG and single-crystal X-ray diffraction. 1 belongs to triclinic system, space group P■ with a = 5.0885(10), b = 6.5574(13), c = 14.016(3) ?, β = 90.67(3)o, V = 436.34(17) ?3, Z = 1, Dc = 1.793 g·cm-3, μ = 0.855 mm-1, Mr = 471.18, F(000) = 235, the final R = 0.0454 and wR = 0.1134 for 1998 observed reflections with I > 2σ(I). The Mn(Ⅱ) ion is coordinated by two N and two O atoms from two Htpc as well as two O atoms from two coordinated water molecules, forming a 0D motif with distorted octahedral coordinate geometry. The adjacent 0D units are linked into 1D chains through hydrogen bond O(1W)–H(1 WB)···O(2), and via the O(1 W)–H(1 WA)···O(1) hydrogen bond the neighboring 1D chains are connected into a 2D supramolecular layer. Moreover, the interactions between the ligand and its complex with CT-DNA were studied by EtBr fluorescence probe, which suggested that these compounds bind to CT-DNA through an intercalation mode. The binding constants were 0.41 and 0.64 for Htpc and complex 1, respectively. It indicates that the interaction between complex 1 and CT-DNA is stronger than Htpc.展开更多
目的分析高血压患者血压变异性(BPV)与心室重构的相关性。方法选择2017年1月至2019年1月在我院初诊为高血压的患者61例,按照左室构型类型将所有患者分为正常左室构型组30例与非正常左室构型组31例。纳入同期我院接受健康体检并证实为健...目的分析高血压患者血压变异性(BPV)与心室重构的相关性。方法选择2017年1月至2019年1月在我院初诊为高血压的患者61例,按照左室构型类型将所有患者分为正常左室构型组30例与非正常左室构型组31例。纳入同期我院接受健康体检并证实为健康的人群39例作为健康对照组。全部纳入者均接受超声心动图检测及24 h动态血压监测(ABPM),对比各组24 h平均舒张压(24 h DBP)、24 h平均收缩压(24 h SBP)、左室后壁厚度(LVPWT)、左室舒张末期内径(LVDd)及舒张期室间隔厚度(IVST)的差异。结果3组中,心室重构组患者的LVMI、RWT水平最高,其次为非心室重构组、健康对照组,组间比较差异具有统计学(P<0.05);3组中,心室重构组患者的24 h SBP-BPV、24h DBP-BPV指标水平最高,其次为非心室重构组,健康对照组,组间比较差异具有统计学意义(P<0.05);非心室重构组的24 h SBP-BPV、24 h DBP-BPV指标水平明显较心室重构组低,差异具有统计学意义(P<0.05);经相关性检验结果显示,高血压患者心室重构相关指标LVMI、RWT水平与血压变异性相关指标24 h SBP-BPV、24 h DBP-BPV水平均呈正相关(r>0,P<0.05)。结论高血压患者BPV与心室重构密切相关,高血压血压变异性大的患者心室重构更为显著。展开更多
基金Supported by the Scientific Research Foundation of Higher Education Institutions of Ningxia(No.NGY2017004)the National Natural Science Foundation of China(Nos.21763022 and 50564043)the Major Innovation Projects for Building First-class Universities in China’s Western Region(No.ZKZD2017003)
文摘A new complex Mn(Htpc)2(H2O)2(1, Htpc = 5-(trifluoromethyl)pyridine-2-carboxylic acid) has been synthesized and characterized by elemental analysis, IR, TG and single-crystal X-ray diffraction. 1 belongs to triclinic system, space group P■ with a = 5.0885(10), b = 6.5574(13), c = 14.016(3) ?, β = 90.67(3)o, V = 436.34(17) ?3, Z = 1, Dc = 1.793 g·cm-3, μ = 0.855 mm-1, Mr = 471.18, F(000) = 235, the final R = 0.0454 and wR = 0.1134 for 1998 observed reflections with I > 2σ(I). The Mn(Ⅱ) ion is coordinated by two N and two O atoms from two Htpc as well as two O atoms from two coordinated water molecules, forming a 0D motif with distorted octahedral coordinate geometry. The adjacent 0D units are linked into 1D chains through hydrogen bond O(1W)–H(1 WB)···O(2), and via the O(1 W)–H(1 WA)···O(1) hydrogen bond the neighboring 1D chains are connected into a 2D supramolecular layer. Moreover, the interactions between the ligand and its complex with CT-DNA were studied by EtBr fluorescence probe, which suggested that these compounds bind to CT-DNA through an intercalation mode. The binding constants were 0.41 and 0.64 for Htpc and complex 1, respectively. It indicates that the interaction between complex 1 and CT-DNA is stronger than Htpc.
文摘目的分析高血压患者血压变异性(BPV)与心室重构的相关性。方法选择2017年1月至2019年1月在我院初诊为高血压的患者61例,按照左室构型类型将所有患者分为正常左室构型组30例与非正常左室构型组31例。纳入同期我院接受健康体检并证实为健康的人群39例作为健康对照组。全部纳入者均接受超声心动图检测及24 h动态血压监测(ABPM),对比各组24 h平均舒张压(24 h DBP)、24 h平均收缩压(24 h SBP)、左室后壁厚度(LVPWT)、左室舒张末期内径(LVDd)及舒张期室间隔厚度(IVST)的差异。结果3组中,心室重构组患者的LVMI、RWT水平最高,其次为非心室重构组、健康对照组,组间比较差异具有统计学(P<0.05);3组中,心室重构组患者的24 h SBP-BPV、24h DBP-BPV指标水平最高,其次为非心室重构组,健康对照组,组间比较差异具有统计学意义(P<0.05);非心室重构组的24 h SBP-BPV、24 h DBP-BPV指标水平明显较心室重构组低,差异具有统计学意义(P<0.05);经相关性检验结果显示,高血压患者心室重构相关指标LVMI、RWT水平与血压变异性相关指标24 h SBP-BPV、24 h DBP-BPV水平均呈正相关(r>0,P<0.05)。结论高血压患者BPV与心室重构密切相关,高血压血压变异性大的患者心室重构更为显著。
