索磷布韦维帕他韦治疗丙型病毒性肝炎的临床疗效及其对肝功能的影响

目的观察索磷布韦维帕他韦治疗丙型病毒性肝炎的临床疗效及其对肝功能的影响。方法选取2015—2020年信宜市人民医院收治的丙型病毒性肝炎患者46例作为研究对象,采用随机数字表法分为对照组和试验组,各23例。对照组采用利巴韦林联合干扰素治疗,疗程为48周;试验组采用索磷布韦维帕他韦治疗,疗程为12周。比较2组临床疗效,治疗前后肝功能指标[天冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、白蛋白(Alb)、总胆红素(TBiL)、谷氨酰转氨酶(GGT)水平及凝血酶原活动度(PAT)]、随访6个月疾病复发率及不良反应发生率。结果试验组病毒应答率为95.65%,高于对照组的73.91%(χ^(2)=4.212,P=0.040)。治疗后,2组AST、ALT水平及试验组TBiL、GGT水平低于治疗前,2组PAT高于治疗前,且试验组AST、ALT、Alb、TBiL、GGT水平低于对照组,PAT高于对照组(P<0.05)。2组随访6个月疾病复发率比较,差异无统计学意义(P>0.05)。试验组治疗期间不良反应发生率为8.70%,与对照组的17.39%比较,差异无统计学意义(χ^(2)=0.767,P=0.381)。结论索磷布韦维帕他韦治疗丙型病毒性肝炎的临床疗效确切,可有效提高病毒应答率,改善患者肝功能,降低疾病复发率,且安全性较高。

Flame Synthesis of Zr/ZSM-5 Catalysts with Tunable Acidity for the Oxidative Dehydrogenation of Propane to Propene

Tuning the surface acidity of ZSM-5 catalyst is essential to achieve desired propene selectivity and yield.Here several ratios of Zr were utilized to modify ZSM-5 via flame spray pyrolysis technique coupled with a pulse spray evaporation system.The interaction between Zr and ZSM-5 in the flame influenced the physicochemical and acidity properties of the Zr/ZSM-5.The increasing Zr ratio in ZSM-5 shows coated layers of irregular nano-sized Zr with an increase in crystallite sizes due to the synergetic effect between Zr and ZSM-5.The surface chemical analysis revealed increased lattice oxygen on the Zr modified ZSM-5(1:4) sample compared to other catalysts.The acidity analysis revealed the Lewis and Br?nsted acid distribution in the weak and medium acid sites on the catalyst surface.However,the increase in Zr loading decreased the concentration of Br?nsted acid sites and tuned the catalyst surface to more Lewis acidity,promoting propene selectivity and hindering the over-oxidation of propene.The modified ZSM-5 catalysts were examined in a fixed bed reactor within 300℃-700℃ at a gas hourly space velocity(GHSV) of 6000 mL·g(catalysts)^(-1)·h^(-1) for the oxidative dehydrogenation of propane(ODHP) to propene.Among the catalysts,Zr/ZSM-5(1:4) exhibited the best propene yield, with 57.19% propane conversion and 75.54% selectivity to propene and the highest stability.This work provides a promising strategy for tuning the surface acidity of ZSM-5 with Zr for ODHP applications.

Fe-Promoted Copper Oxide Thin-Film Catalysts for the Catalytic Reduction of N_(2)O in the Presence of Methane

Thin-film catalysts are recently recognized as promising catalysts due to their reduced amount of materials and good catalytic activity,leading to low-cost and high-efficiency catalysts.A series of CuFeO_(x)thin-film catalysts were prepared with different Fe contents using a one-step method as well as tested for the catalytic reduction of nitrous oxide(N_(2)O)in the presence of CH_(4)at a high GH SV of 185000 mL/(g·h).The increase of iron strongly affects the dispersion and leads to the creation of a less-active segregated Fe_(2)O_(3)phase,which was confirmed by XRD,EDX,and XPS outcomes.The results show that the synergistic properties between Cu and Fe,which affect the CuFeOxfilm catalysts in many aspects,such as the hollow-like texture,specific surface area,nano-crystallite size,the surface contents of Cu^(+),Fe^(3+),and oxygen species,the reductive strength and the strong active sites on the surface.Using DFT calculations,the adsorption and decomposition energy profiles of N_(2)O on the CuFeO_(2)(012)surface model were explored.The surface Fe-site and hollow-site are active for N_(2)O decomposition,and the decomposition energy barriers on the Fe-site and the hollow-site are 1.02 eV and 1.25 eV respectively at 0 K.The strategy adopted here to tailor the activity through low-doping Fe-oxide catalysts could establish a promising way to improve the catalytic reduction of N_(2)O with CH_(4).