Cataract is the leading cause of visual impairment globally.The scarcity and uneven distribution of ophthalmologists seriously hinder early visual impairment grading for cataract patients in the clin-ic.In this study,...Cataract is the leading cause of visual impairment globally.The scarcity and uneven distribution of ophthalmologists seriously hinder early visual impairment grading for cataract patients in the clin-ic.In this study,a deep learning-based automated grading system of visual impairment in cataract patients is proposed using a multi-scale efficient channel attention convolutional neural network(MECA_CNN).First,the efficient channel attention mechanism is applied in the MECA_CNN to extract multi-scale features of fundus images,which can effectively focus on lesion-related regions.Then,the asymmetric convolutional modules are embedded in the residual unit to reduce the infor-mation loss of fine-grained features in fundus images.In addition,the asymmetric loss function is applied to address the problem of a higher false-negative rate and weak generalization ability caused by the imbalanced dataset.A total of 7299 fundus images derived from two clinical centers are em-ployed to develop and evaluate the MECA_CNN for identifying mild visual impairment caused by cataract(MVICC),moderate to severe visual impairment caused by cataract(MSVICC),and nor-mal sample.The experimental results demonstrate that the MECA_CNN provides clinically meaning-ful performance for visual impairment grading in the internal test dataset:MVICC(accuracy,sensi-tivity,and specificity;91.3%,89.9%,and 92%),MSVICC(93.2%,78.5%,and 96.7%),and normal sample(98.1%,98.0%,and 98.1%).The comparable performance in the external test dataset is achieved,further verifying the effectiveness and generalizability of the MECA_CNN model.This study provides a deep learning-based practical system for the automated grading of visu-al impairment in cataract patients,facilitating the formulation of treatment strategies in a timely man-ner and improving patients’vision prognosis.展开更多
目的比较三种多焦点人工晶状体植入术后的视觉质量。方法将56例(72眼)白内障患者分为3组,每组24眼,分别植入ZEISS AT LISA tri 839MP人工晶状体、Oculentis L-313 MF30人工晶状体和Alcon SN6AD1人工晶状体。术后1d、1周、1个月及3个月观...目的比较三种多焦点人工晶状体植入术后的视觉质量。方法将56例(72眼)白内障患者分为3组,每组24眼,分别植入ZEISS AT LISA tri 839MP人工晶状体、Oculentis L-313 MF30人工晶状体和Alcon SN6AD1人工晶状体。术后1d、1周、1个月及3个月观察3组远(5 m)、中(80 cm)、近(40 cm)视力及并发症等指标,术后3个月行对比敏感度测试,并绘制3组人工晶体离焦曲线,同时问卷调查3组的视觉满意度及脱镜率。结果3组多焦人工晶状体在提升患者远视力方面效果均突出,结果接近于正视力;3组术后裸眼中、近视力及矫正中、近视力差异均有统计学意义(均P<0.05)。3组对比敏感度检测结果均处于正常人水平。3组仅少数患者存在轻度视觉不良症状,脱镜率分别为95.83%、91.67%及83.33%。AT LISA tri 839MP人工晶体满意度高于其他两种(P<0.05)。结论新一代的三焦点人工晶状体ATLISAtri 839MP可有效提高白内障患者术后全程视力,在视力提升、脱镜率及患者满意度方面优于L-313 MF30及SN6AD1人工晶状体。展开更多
基金the National Natural Science Foundation of China(No.62276210,82201148,61775180)the Natural Science Basic Research Program of Shaanxi Province(No.2022JM-380)+3 种基金the Shaanxi Province College Students'Innovation and Entrepreneurship Training Program(No.S202311664128X)the Natural Science Foundation of Zhejiang Province(No.LQ22H120002)the Medical Health Science and Technology Project of Zhejiang Province(No.2022RC069,2023KY1140)the Natural Science Foundation of Ningbo(No.2023J390)。
文摘Cataract is the leading cause of visual impairment globally.The scarcity and uneven distribution of ophthalmologists seriously hinder early visual impairment grading for cataract patients in the clin-ic.In this study,a deep learning-based automated grading system of visual impairment in cataract patients is proposed using a multi-scale efficient channel attention convolutional neural network(MECA_CNN).First,the efficient channel attention mechanism is applied in the MECA_CNN to extract multi-scale features of fundus images,which can effectively focus on lesion-related regions.Then,the asymmetric convolutional modules are embedded in the residual unit to reduce the infor-mation loss of fine-grained features in fundus images.In addition,the asymmetric loss function is applied to address the problem of a higher false-negative rate and weak generalization ability caused by the imbalanced dataset.A total of 7299 fundus images derived from two clinical centers are em-ployed to develop and evaluate the MECA_CNN for identifying mild visual impairment caused by cataract(MVICC),moderate to severe visual impairment caused by cataract(MSVICC),and nor-mal sample.The experimental results demonstrate that the MECA_CNN provides clinically meaning-ful performance for visual impairment grading in the internal test dataset:MVICC(accuracy,sensi-tivity,and specificity;91.3%,89.9%,and 92%),MSVICC(93.2%,78.5%,and 96.7%),and normal sample(98.1%,98.0%,and 98.1%).The comparable performance in the external test dataset is achieved,further verifying the effectiveness and generalizability of the MECA_CNN model.This study provides a deep learning-based practical system for the automated grading of visu-al impairment in cataract patients,facilitating the formulation of treatment strategies in a timely man-ner and improving patients’vision prognosis.
文摘目的比较三种多焦点人工晶状体植入术后的视觉质量。方法将56例(72眼)白内障患者分为3组,每组24眼,分别植入ZEISS AT LISA tri 839MP人工晶状体、Oculentis L-313 MF30人工晶状体和Alcon SN6AD1人工晶状体。术后1d、1周、1个月及3个月观察3组远(5 m)、中(80 cm)、近(40 cm)视力及并发症等指标,术后3个月行对比敏感度测试,并绘制3组人工晶体离焦曲线,同时问卷调查3组的视觉满意度及脱镜率。结果3组多焦人工晶状体在提升患者远视力方面效果均突出,结果接近于正视力;3组术后裸眼中、近视力及矫正中、近视力差异均有统计学意义(均P<0.05)。3组对比敏感度检测结果均处于正常人水平。3组仅少数患者存在轻度视觉不良症状,脱镜率分别为95.83%、91.67%及83.33%。AT LISA tri 839MP人工晶体满意度高于其他两种(P<0.05)。结论新一代的三焦点人工晶状体ATLISAtri 839MP可有效提高白内障患者术后全程视力,在视力提升、脱镜率及患者满意度方面优于L-313 MF30及SN6AD1人工晶状体。