研制出一款小像元10μm中心距红外焦平面探测器CMOS(complementary metal oxide semiconductor)读出电路ROIC(read out integrated circuit)。读出电路设计包括积分后读出(integration then reading,ITR)和积分同时读出(integration whi...研制出一款小像元10μm中心距红外焦平面探测器CMOS(complementary metal oxide semiconductor)读出电路ROIC(read out integrated circuit)。读出电路设计包括积分后读出(integration then reading,ITR)和积分同时读出(integration while reading,IWR)模式,ITR模式下有2档增益,电荷满阱容量分别为4.3 Me^(−)和1.6 Me^(−),其他功能包括抗晕、串口功能控制以及全芯片电注入测试功能。读出电路采用0.18μm工艺,电源电压3.3 V,测试结果表现出良好的性能:在77 K条件下,全帧频100 Hz,读出电路噪声小于0.2 mV。本文介绍了该款读出电路设计的基本架构,分析了在小的积分电容下电路抗干扰能力的设计。在测试过程中,发现了盲元拖尾现象,分析了拖尾现象产生的原因,为解决拖尾现象设计了抗晕管栅压产生电路,最后给出了整个电路的测试结果。展开更多
Objective To explore plasma Nesfatin-1 concentration and its correlation with hypothalamic pituitary adrenal(HPA) axis in depression model rats. Methods Twelve SD rats were randomly divided into normal control group(N...Objective To explore plasma Nesfatin-1 concentration and its correlation with hypothalamic pituitary adrenal(HPA) axis in depression model rats. Methods Twelve SD rats were randomly divided into normal control group(NCG) and depression model group(DMG). DMG received 5 consecutive weeks of 7 different chronic unpredictable mild stress(CUMS). The behavior of rats was evaluated by an open field test,sucrose preference test,and forced swimming test(FST). The concentration of plasma corticosterone and Nesfatin-1 were measured with an enzyme-linked immuno-sorbent assay(ELISA). Results Compared with NCG,DMG had a lower weight gain,lower index of sucrose preference and spent longer time being immobile in FST while all of these differences were statistically significant(P<0.05). The plasma concentrations of corticosterone and Nesfatin-1 were significantly higher in DMG than in theN CG(P<0.05). The plasma concentration of Nesfatin-1in DMG was positively correlated with the plasma corticosterone concentration. Conclusion CUMS could induce depression-like behavior in rats and increase the plasma concentration of Nesfatin-1 and corticosterone,while the HPA axis hyperactivity induced by CUMS may be associated with the increased concentration of Nesfatin-1.展开更多
Nesfatin-1 is a novel appetite inhibitory factor. The studies in recent years show that Nesfatin-1 is also involved in the process of stress response. The studies on pathogenesis of Nesfatin-1 mediated stress response...Nesfatin-1 is a novel appetite inhibitory factor. The studies in recent years show that Nesfatin-1 is also involved in the process of stress response. The studies on pathogenesis of Nesfatin-1 mediated stress response and stress-related anxiety and depressive disorder were reviewed in this paper.展开更多
文摘研制出一款小像元10μm中心距红外焦平面探测器CMOS(complementary metal oxide semiconductor)读出电路ROIC(read out integrated circuit)。读出电路设计包括积分后读出(integration then reading,ITR)和积分同时读出(integration while reading,IWR)模式,ITR模式下有2档增益,电荷满阱容量分别为4.3 Me^(−)和1.6 Me^(−),其他功能包括抗晕、串口功能控制以及全芯片电注入测试功能。读出电路采用0.18μm工艺,电源电压3.3 V,测试结果表现出良好的性能:在77 K条件下,全帧频100 Hz,读出电路噪声小于0.2 mV。本文介绍了该款读出电路设计的基本架构,分析了在小的积分电容下电路抗干扰能力的设计。在测试过程中,发现了盲元拖尾现象,分析了拖尾现象产生的原因,为解决拖尾现象设计了抗晕管栅压产生电路,最后给出了整个电路的测试结果。
基金supported by the National Key Technology Support Program(2012BAl01805)the Natural Science Foundation of Hubei Province(2015CFA023)National Natural Science Foundation of China(81571325)
文摘Objective To explore plasma Nesfatin-1 concentration and its correlation with hypothalamic pituitary adrenal(HPA) axis in depression model rats. Methods Twelve SD rats were randomly divided into normal control group(NCG) and depression model group(DMG). DMG received 5 consecutive weeks of 7 different chronic unpredictable mild stress(CUMS). The behavior of rats was evaluated by an open field test,sucrose preference test,and forced swimming test(FST). The concentration of plasma corticosterone and Nesfatin-1 were measured with an enzyme-linked immuno-sorbent assay(ELISA). Results Compared with NCG,DMG had a lower weight gain,lower index of sucrose preference and spent longer time being immobile in FST while all of these differences were statistically significant(P<0.05). The plasma concentrations of corticosterone and Nesfatin-1 were significantly higher in DMG than in theN CG(P<0.05). The plasma concentration of Nesfatin-1in DMG was positively correlated with the plasma corticosterone concentration. Conclusion CUMS could induce depression-like behavior in rats and increase the plasma concentration of Nesfatin-1 and corticosterone,while the HPA axis hyperactivity induced by CUMS may be associated with the increased concentration of Nesfatin-1.
基金supported by the National Science Foundation of China(1712)Natural Science Foundation of Hubei Province of China(201CFA02)
文摘Nesfatin-1 is a novel appetite inhibitory factor. The studies in recent years show that Nesfatin-1 is also involved in the process of stress response. The studies on pathogenesis of Nesfatin-1 mediated stress response and stress-related anxiety and depressive disorder were reviewed in this paper.
