盐酸小檗碱/海藻酸钠/淀粉复合凝胶珠制备及体外释放行为研究

以海藻酸钠(SA)和淀粉(ST)为原料制备盐酸小檗碱(BH)复合凝胶珠,以期为BH的临床应用和制剂开发提供理论依据。采用滴制法制备BH复合凝胶珠,考察SA与ST复合对凝胶珠的溶胀率和BH释放性能的影响。结果表明,SA与ST复合能明显影响凝胶珠对BH的载药量和释放性。SA与ST质量比为3∶1时,复合凝胶珠的载药量为8.2%,而单纯SA凝胶珠载药量为3.5%;该复合凝胶珠在pH值为2.1的缓冲溶液中1.5 h时,BH累积释放率为27.01%,而单纯SA凝胶珠累积释放率为52.83%;该复合凝胶珠在pH值为6.8的缓冲溶液中1.5 h时,累积释放率为43.56%,而单纯SA凝胶珠累积释放率为69.38%;在0~3.5 h内复合凝胶珠在pH值为2.1的缓冲溶液中体外释放以药物扩散和骨架溶蚀协同作用为主,符合零级释放模型,而单纯SA凝胶珠BH释放遵循Higuchi方程。结果提示,SA与ST复合制备的凝胶珠能明显延缓BH的释放,其制备工艺简单,具有pH依赖性。

基于敏感度分析方法的拱状橡胶三向隔震支座竖向刚度研究

为了更好地实现博物馆文物储藏柜在地震中的安全防护,设计了一种橡胶减隔震装置——拱状橡胶三向隔震支座。通过竖向压缩试验验证有限元模型有效性,利用正交设计进行多工况有限元模拟计算,研究影响支座竖向压缩刚度的因素,结合影响因素的敏感度分析支座内部圆拱橡胶的镂空尺寸对竖向压缩刚度的影响规律。结果表明:拱状橡胶三向隔震支座具有稳定的压缩性能和良好的竖向承载力;在材料属性和整体尺寸不变的基础上,通过敏感度大小进行分析,将3个影响因素小的尺寸参数进行整合,得到尺寸参数和竖向镂空系数是影响竖向压缩刚度的主要参数,并进行了样本数据拟合,得到了拱状橡胶三向隔震支座竖向压缩刚度的拟合计算公式。

Iteration and evaluation of shale oil development technology for continental rift lake basins

By benchmarking with the iteration of drilling technology,fracturing technology and well placement mode for shale oil and gas development in the United States and considering the geological characteristics and development difficulties of shale oil in the Jiyang continental rift lake basin,East China,the development technology system suitable for the geological characteristics of shale oil in continental rift lake basins has been primarily formed through innovation and iteration of the development,drilling and fracturing technologies.The technology system supports the rapid growth of shale oil production and reduces the development investment cost.By comparing it with the shale oil development technology in the United States,the prospect of the shale oil development technology iteration in continental rift lake basins is proposed.It is suggested to continuously strengthen the overall three-dimensional development,improve the precision level of engineering technology,upgrade the engineering technical indicator system,accelerate the intelligent optimization of engineering equipment,explore the application of complex structure wells,form a whole-process integrated quality management system from design to implementation,and constantly innovate the concept and technology of shale oil development,so as to promote the realization of extensive,beneficial and high-quality development of shale oil in continental rift lake basins.