Marine bacterial strain Bacillus sp.CS30 exhibited high anticancer activity against Huh7.5 human liver cancer.We purified the corresponding anticancer agent by sequential acidic precipitation,methanol extraction,Sepha...Marine bacterial strain Bacillus sp.CS30 exhibited high anticancer activity against Huh7.5 human liver cancer.We purified the corresponding anticancer agent by sequential acidic precipitation,methanol extraction,Sephadex LH-20 chromatography,and reversed phase high-performance liquid chromatography(RP-HPLC),then analyzed it in mass spectrometry.Based on the results of purification and mass spectrometry,we deduced that the anticancer agent was the same component as our previously purified antifungal agent surfactin CS30-2.However,to the best of our knowledge,this is the first report on the surfactin possessing both antifungal and anticancer activities.Surfactin CS30-2 was demonstrated to exhibit high anticancer activity in a dose-dependent manner against Huh7.5 liver cancer cells.Further investigation showed that surfactin CS30-2 induced the increased generation of reactive oxygen species(ROS)and severe disruption of cell membrane,thus leading to cell death.However,unlike previously reported surfactins,surfactin CS30-2 caused cancer cell death via necrosis instead of apoptosis.展开更多
The scientific evaluation of trends in China's future energy demands is highly important.Using provincial-level panel data from 1995 to 2015,we studied the relationships between the economic aggregate,the developm...The scientific evaluation of trends in China's future energy demands is highly important.Using provincial-level panel data from 1995 to 2015,we studied the relationships between the economic aggregate,the development of energy-intensive industries and energy demand from the perspective of changes in the proportion of energy-intensive industries in the national economy.We find that economic aggregate affects energy demand through energy-intensive industries and that changes in the economic structure are the key factor for change in energy demand.This means that China's future energy demand will be much lower than that contained in forecasts that did not consider this factor.Comprehensively promoting green-tech development and strengthening the regulation of energy-extensive industries will be one of the key options for realizing China's objective of controlling total energy consumption.展开更多
Green development is an inevitable requirement to develop a modern high-quality economy,and it is also a fundamental solution for pollution.Fiscal policy,technical innovation,price mechanism,carbon market,and compulso...Green development is an inevitable requirement to develop a modern high-quality economy,and it is also a fundamental solution for pollution.Fiscal policy,technical innovation,price mechanism,carbon market,and compulsory equipment upgradation are all important policy tools to achieve the green development.In addition,the market should play a decisive role in resource allocation,and innovations in price mechanism should be encouraged since the price mechanism directly influences market efficiency and social stability.展开更多
基金Supported by the National Natural Science Foundation of China(No.31600035)to WU Shimei。
文摘Marine bacterial strain Bacillus sp.CS30 exhibited high anticancer activity against Huh7.5 human liver cancer.We purified the corresponding anticancer agent by sequential acidic precipitation,methanol extraction,Sephadex LH-20 chromatography,and reversed phase high-performance liquid chromatography(RP-HPLC),then analyzed it in mass spectrometry.Based on the results of purification and mass spectrometry,we deduced that the anticancer agent was the same component as our previously purified antifungal agent surfactin CS30-2.However,to the best of our knowledge,this is the first report on the surfactin possessing both antifungal and anticancer activities.Surfactin CS30-2 was demonstrated to exhibit high anticancer activity in a dose-dependent manner against Huh7.5 liver cancer cells.Further investigation showed that surfactin CS30-2 induced the increased generation of reactive oxygen species(ROS)and severe disruption of cell membrane,thus leading to cell death.However,unlike previously reported surfactins,surfactin CS30-2 caused cancer cell death via necrosis instead of apoptosis.
基金the project of the National Natural Science Fund of China,“Research on Household Energy Consumption in China”(71774165)the Research Fund of Renmin University of China,i.e.,the Basic Research Funds for the Central Universities(17XNS001 and 11XNL004).
文摘The scientific evaluation of trends in China's future energy demands is highly important.Using provincial-level panel data from 1995 to 2015,we studied the relationships between the economic aggregate,the development of energy-intensive industries and energy demand from the perspective of changes in the proportion of energy-intensive industries in the national economy.We find that economic aggregate affects energy demand through energy-intensive industries and that changes in the economic structure are the key factor for change in energy demand.This means that China's future energy demand will be much lower than that contained in forecasts that did not consider this factor.Comprehensively promoting green-tech development and strengthening the regulation of energy-extensive industries will be one of the key options for realizing China's objective of controlling total energy consumption.
文摘Green development is an inevitable requirement to develop a modern high-quality economy,and it is also a fundamental solution for pollution.Fiscal policy,technical innovation,price mechanism,carbon market,and compulsory equipment upgradation are all important policy tools to achieve the green development.In addition,the market should play a decisive role in resource allocation,and innovations in price mechanism should be encouraged since the price mechanism directly influences market efficiency and social stability.
