运用Discovery Studio 4.5软件,通过同源建模及分子动力学优化获得柞蚕小吐白水软化病毒(Ap IV)3C蛋白酶的3D结构;通过分子对接对天然产物库进行虚拟筛选,得到1个Ap IV 3C蛋白酶的有效抑制剂3',4',5,7-四羟基异黄酮(Orobol).分...运用Discovery Studio 4.5软件,通过同源建模及分子动力学优化获得柞蚕小吐白水软化病毒(Ap IV)3C蛋白酶的3D结构;通过分子对接对天然产物库进行虚拟筛选,得到1个Ap IV 3C蛋白酶的有效抑制剂3',4',5,7-四羟基异黄酮(Orobol).分子对接和分子动力学(MD)模拟结果进一步证明Orobol能稳定结合于Ap IV 3C蛋白酶的结合口袋处.体内外的Ap IV病毒抑制实验结果表明,Orobol具有良好的抗病毒活性.展开更多
Three dimensional（3D） displacements, which can be translated further into 3D strain, are key parameters tor design, manufacturing and quality control. Using different optical setups, phase-shift methods, and algorit...Three dimensional（3D） displacements, which can be translated further into 3D strain, are key parameters tor design, manufacturing and quality control. Using different optical setups, phase-shift methods, and algorithms, several different 3D electronic speckle pattern interferometry（ESPl） systems for displacement and strain measurements have been achieved and commercialized. This paper provides a review of the recent developments in ESPI systems for 3D displacement and strain measurement. After an overview of the fundamentals of ESP! theory, temporal phase-shift, and spatial phase-shift techniques, 3D deformation measurements by the temporal phase-shift ESPI system, which is suited well for static measurement, and by the spatial phase-shift ESPI system, which is particularly useful for dynamic measurement, are discussed. For each method, the basic theory, a brief derivation and different optical layouts are presented. The state of art application, potential and limitation of the ESPI systems are shown and demonstrated.展开更多
A tri-color quad-beam digital shearography is proposed to achieve the measurement of absolute three-dimensional(3D) displacement gradients.Four laser beams with three different center wavelengths are symmetrically irr...A tri-color quad-beam digital shearography is proposed to achieve the measurement of absolute three-dimensional(3D) displacement gradients.Four laser beams with three different center wavelengths are symmetrically irradiated to the object surface from the upper and lower left and right directions.Four phase maps are then extracted from the two interferograms obtained from two shots.Based on these four phase maps,the absolute 3D displacement gradients are determined.This means of absolute 3D displacement gradient measurement effectively improves the measurement capability of digital shearography and expands its application range.展开更多
文摘运用Discovery Studio 4.5软件,通过同源建模及分子动力学优化获得柞蚕小吐白水软化病毒(Ap IV)3C蛋白酶的3D结构;通过分子对接对天然产物库进行虚拟筛选,得到1个Ap IV 3C蛋白酶的有效抑制剂3',4',5,7-四羟基异黄酮(Orobol).分子对接和分子动力学(MD)模拟结果进一步证明Orobol能稳定结合于Ap IV 3C蛋白酶的结合口袋处.体内外的Ap IV病毒抑制实验结果表明,Orobol具有良好的抗病毒活性.
基金supported by National Natural Science Foundation of China(Grant Nos.51275054,51075116)
文摘Three dimensional（3D） displacements, which can be translated further into 3D strain, are key parameters tor design, manufacturing and quality control. Using different optical setups, phase-shift methods, and algorithms, several different 3D electronic speckle pattern interferometry（ESPl） systems for displacement and strain measurements have been achieved and commercialized. This paper provides a review of the recent developments in ESPI systems for 3D displacement and strain measurement. After an overview of the fundamentals of ESP! theory, temporal phase-shift, and spatial phase-shift techniques, 3D deformation measurements by the temporal phase-shift ESPI system, which is suited well for static measurement, and by the spatial phase-shift ESPI system, which is particularly useful for dynamic measurement, are discussed. For each method, the basic theory, a brief derivation and different optical layouts are presented. The state of art application, potential and limitation of the ESPI systems are shown and demonstrated.
基金supported by the National Natural Science Foundation of China (Nos.52075045 and 52075044)the Natural Science Foundation of Beijing Municipality,China (No.4212047)。
文摘A tri-color quad-beam digital shearography is proposed to achieve the measurement of absolute three-dimensional(3D) displacement gradients.Four laser beams with three different center wavelengths are symmetrically irradiated to the object surface from the upper and lower left and right directions.Four phase maps are then extracted from the two interferograms obtained from two shots.Based on these four phase maps,the absolute 3D displacement gradients are determined.This means of absolute 3D displacement gradient measurement effectively improves the measurement capability of digital shearography and expands its application range.
