目的探讨环孢素A(CsA)在大鼠急性脊髓损伤后神经炎症反应中的作用,为CsA合理地用于脊髓损伤的临床治疗提供理论依据。方法成年雄性SD大鼠75只,随机分为假手术组(sham组)、环孢素A治疗组(CsA组)、生理盐水治疗组(NS组)。采用行为学评估、...目的探讨环孢素A(CsA)在大鼠急性脊髓损伤后神经炎症反应中的作用,为CsA合理地用于脊髓损伤的临床治疗提供理论依据。方法成年雄性SD大鼠75只,随机分为假手术组(sham组)、环孢素A治疗组(CsA组)、生理盐水治疗组(NS组)。采用行为学评估、H-E染色、qRT-PCR及免疫组织化学技术检测脊髓损伤大鼠的后肢运动功能恢复、组织损伤面积、促炎因子[白细胞介素(IL)-1β,IL-6,肿瘤坏死因子-α(TNF-α)]的表达。结果行为学评估显示,随着观察时间点推移,CsA组和NS组大鼠的BBB评分逐渐升高,后肢运动功能逐渐恢复,但CsA组大鼠的BBB评分自脊髓损伤后14 d起均显著高于NS组(P<0.01)。H-E染色显示,脊髓损伤后28 d CsA组的损伤面积百分比显著低于NS组(P<0.01)。qRT-PCR显示,脊髓损伤后6 h和1 d CsA组脊髓的IL-1β,IL-6及TNF-α的mRNA水平显著低于NS组(P<0.01)。免疫组织化学显示,CsA组脊髓损伤后6 h和1 d的IL-1β,IL-6及TNF-α在脊髓灰质神经元及神经胶质细胞的胞质表达的相对蛋白水平显著低于NS组(P<0.01)。结论CsA可能通过减轻脊髓损伤后局部炎症反应而减缓继发性脊髓损伤的进展。展开更多
Plant landscaping in courtyard design was studied from four perspectives of building, water, road, garden setting and plant landscaping. Landscape designs in Guangzhou Baiyun Hotel, the Humble Administrator's Gard...Plant landscaping in courtyard design was studied from four perspectives of building, water, road, garden setting and plant landscaping. Landscape designs in Guangzhou Baiyun Hotel, the Humble Administrator's Garden (Suzhou), and bamboo pathway of Small Yingzhou in the West Lake (Hangzhou) to improve scientific and artistic properties of plant landscaping, and develop economic, social and ecological effects of garden green spaces to the most.展开更多
The different approaches used for target decomposition （TD） theory in radar polarimetry are reviewed and three main types of theorems are introduced： those based on Mueller matrix, those using an eigenvector analys...The different approaches used for target decomposition （TD） theory in radar polarimetry are reviewed and three main types of theorems are introduced： those based on Mueller matrix, those using an eigenvector analysis of the coherency matrix, and those employing coherent decomposition of the scattering matrix. Support vector machine （SVM）, as a novel approach in pattern recognition, has demonstrated success in many fields. A new algorithm of target classification, by combining target decomposition and the support vector machine, is proposed. To conduct the experiment, the polarimetric synthetic aperture radar （SAR） data are used. Experimental results show that it is feasible and efficient to target classification by applying target decomposition to extract scattering mechanisms, and the effects of kernel function and its parameters on the classification efficiency are significant.展开更多
文摘目的探讨环孢素A(CsA)在大鼠急性脊髓损伤后神经炎症反应中的作用,为CsA合理地用于脊髓损伤的临床治疗提供理论依据。方法成年雄性SD大鼠75只,随机分为假手术组(sham组)、环孢素A治疗组(CsA组)、生理盐水治疗组(NS组)。采用行为学评估、H-E染色、qRT-PCR及免疫组织化学技术检测脊髓损伤大鼠的后肢运动功能恢复、组织损伤面积、促炎因子[白细胞介素(IL)-1β,IL-6,肿瘤坏死因子-α(TNF-α)]的表达。结果行为学评估显示,随着观察时间点推移,CsA组和NS组大鼠的BBB评分逐渐升高,后肢运动功能逐渐恢复,但CsA组大鼠的BBB评分自脊髓损伤后14 d起均显著高于NS组(P<0.01)。H-E染色显示,脊髓损伤后28 d CsA组的损伤面积百分比显著低于NS组(P<0.01)。qRT-PCR显示,脊髓损伤后6 h和1 d CsA组脊髓的IL-1β,IL-6及TNF-α的mRNA水平显著低于NS组(P<0.01)。免疫组织化学显示,CsA组脊髓损伤后6 h和1 d的IL-1β,IL-6及TNF-α在脊髓灰质神经元及神经胶质细胞的胞质表达的相对蛋白水平显著低于NS组(P<0.01)。结论CsA可能通过减轻脊髓损伤后局部炎症反应而减缓继发性脊髓损伤的进展。
文摘Plant landscaping in courtyard design was studied from four perspectives of building, water, road, garden setting and plant landscaping. Landscape designs in Guangzhou Baiyun Hotel, the Humble Administrator's Garden (Suzhou), and bamboo pathway of Small Yingzhou in the West Lake (Hangzhou) to improve scientific and artistic properties of plant landscaping, and develop economic, social and ecological effects of garden green spaces to the most.
文摘The different approaches used for target decomposition （TD） theory in radar polarimetry are reviewed and three main types of theorems are introduced： those based on Mueller matrix, those using an eigenvector analysis of the coherency matrix, and those employing coherent decomposition of the scattering matrix. Support vector machine （SVM）, as a novel approach in pattern recognition, has demonstrated success in many fields. A new algorithm of target classification, by combining target decomposition and the support vector machine, is proposed. To conduct the experiment, the polarimetric synthetic aperture radar （SAR） data are used. Experimental results show that it is feasible and efficient to target classification by applying target decomposition to extract scattering mechanisms, and the effects of kernel function and its parameters on the classification efficiency are significant.
