目的分析1990—2019年中国女性人群归因于代谢危险因素乳腺癌疾病负担的变化趋势,为制定有针对性的防治策略提供科学依据。方法基于2019年全球疾病负担研究(Global burden of disease study 2019,GBD 2019)数据库,采用死亡、伤残调整生...目的分析1990—2019年中国女性人群归因于代谢危险因素乳腺癌疾病负担的变化趋势,为制定有针对性的防治策略提供科学依据。方法基于2019年全球疾病负担研究(Global burden of disease study 2019,GBD 2019)数据库,采用死亡、伤残调整生命年(Disability adjusted life year,DALY)、伤残损失健康寿命年(Years lived with disability,YLD)、早死损失寿命年(Years of life lost,YLL)和人群归因分值(Population attributable faction,PAF),分析中国女性人群归因于代谢危险因素的乳腺癌疾病负担变化趋势。结果1990—2019年,中国与全球归因代谢危险因素乳腺癌的年龄标化死亡率和DALY率均呈上升趋势,中国归因标化死亡率和DALY率平均每年分别上升1.79%(95%CI:1.51%~2.07%,P<0.05)和1.77%(95%CI:1.45%~2.09%,P<0.05),全球归因标化死亡率和DALY率平均每年分别上升0.80%(95%CI:0.69%~0.92%,P<0.05)和0.97%(95%CI:0.91%~1.04%,P<0.05),中国上升幅度高于全球。1990—2019年中国女性各年龄组归因代谢危险因素乳腺癌所致的PAF存在差异,50~69以及70岁以上年龄组PAF值较大;归因DALY率在50~69年龄组达最高,归因死亡率随年龄的增长呈上升趋势,在≥70岁年龄组达最高。与1990年相比,2019年代谢危险因素中高体重指数所致乳腺癌的死亡人数以及DALY分别增长了450.34%和440.28%,死亡率以及DALY率分别增长了352.48%和344.20%。结论中国女性人群归因于代谢危险因素乳腺癌疾病负担沉重,中老年女性人群为高危人群。此外,代谢危险因素中高体重指数是重要危险因素。展开更多
Leaf color and photosynthesis are important factors for rice growth and development.Hence,improving the photosynthetic rate is an effective approach for increasing rice yield.We isolated a gene,chlorophyllide-a oxygen...Leaf color and photosynthesis are important factors for rice growth and development.Hence,improving the photosynthetic rate is an effective approach for increasing rice yield.We isolated a gene,chlorophyllide-a oxygenase 1(OsCAO1),which characterized a rice near-isogenic line named fgl(faded green leaf).展开更多
Anthocyanins are widely distributed in one or more parts of rice(Oryza sativa L.)plants,including seed coat,stigma,apiculus,leaf sheath and leaf blade,and are the main pigments used in rice to achieve different colors...Anthocyanins are widely distributed in one or more parts of rice(Oryza sativa L.)plants,including seed coat,stigma,apiculus,leaf sheath and leaf blade,and are the main pigments used in rice to achieve different colors(Hou et al,2009;Aizza and Dornelas,2011).In rice,tissue-specific color traits(especially the color of apiculus,namely the lemma and palea of the spikelet)are not only important for rice variety identification but also important for linkage analysis and rice domestication research(Saitoh et al,2004;Fan et al,2007;Lin et al,2019).The apiculus color is controlled by the complementary functions of three pairs of dominant genes,C,A and P.Gene C(chromogen)is a pigment gene,which is the basic gene for producing pigments.Gene A(activator)activates gene C,converting the chromogen into anthocyanins,and gene P(purple)controls the distribution of anthocyanins in various organs(Reddy,1996;Sakamoto et al,2001).展开更多
文摘目的分析1990—2019年中国女性人群归因于代谢危险因素乳腺癌疾病负担的变化趋势,为制定有针对性的防治策略提供科学依据。方法基于2019年全球疾病负担研究(Global burden of disease study 2019,GBD 2019)数据库,采用死亡、伤残调整生命年(Disability adjusted life year,DALY)、伤残损失健康寿命年(Years lived with disability,YLD)、早死损失寿命年(Years of life lost,YLL)和人群归因分值(Population attributable faction,PAF),分析中国女性人群归因于代谢危险因素的乳腺癌疾病负担变化趋势。结果1990—2019年,中国与全球归因代谢危险因素乳腺癌的年龄标化死亡率和DALY率均呈上升趋势,中国归因标化死亡率和DALY率平均每年分别上升1.79%(95%CI:1.51%~2.07%,P<0.05)和1.77%(95%CI:1.45%~2.09%,P<0.05),全球归因标化死亡率和DALY率平均每年分别上升0.80%(95%CI:0.69%~0.92%,P<0.05)和0.97%(95%CI:0.91%~1.04%,P<0.05),中国上升幅度高于全球。1990—2019年中国女性各年龄组归因代谢危险因素乳腺癌所致的PAF存在差异,50~69以及70岁以上年龄组PAF值较大;归因DALY率在50~69年龄组达最高,归因死亡率随年龄的增长呈上升趋势,在≥70岁年龄组达最高。与1990年相比,2019年代谢危险因素中高体重指数所致乳腺癌的死亡人数以及DALY分别增长了450.34%和440.28%,死亡率以及DALY率分别增长了352.48%和344.20%。结论中国女性人群归因于代谢危险因素乳腺癌疾病负担沉重,中老年女性人群为高危人群。此外,代谢危险因素中高体重指数是重要危险因素。
基金supported by the Shenzhen Science and Technology Program,China(Grant No.KQTD2016113010482651)Natural Science Foundation of Zhejiang Province in China(Grant No.LR20C130001)Hainan Yazhou Bay Seed Laboratory,China(Grant No.B21HJ0219)。
文摘Leaf color and photosynthesis are important factors for rice growth and development.Hence,improving the photosynthetic rate is an effective approach for increasing rice yield.We isolated a gene,chlorophyllide-a oxygenase 1(OsCAO1),which characterized a rice near-isogenic line named fgl(faded green leaf).
文摘目的探索肝硬化腹水患者的腹水endocan水平在自发性腹膜炎(spontaneous bacterial peritonitis,SBP)诊断中的作用。方法纳入2018年1月至2019年6月在我院住院的失代偿性肝硬化腹水患者161例,其中SBP组35例,非SBP组126例,留取入院时腹水标本,同时收集人口学资料及实验室检查资料,用ELISA方法检测腹水中endocan浓度,采用logstic回归模型分析SBP的独立影响因素,ROC曲线分析腹水endocan对SBP的诊断价值。结果腹水endocan水平在SBP组显著高于非SBP组[398.451(318.762~460.673)pg/mL vs 199.838(133.366~303.226)pg/mL,P<0.001]。logistic回归模型进行SBP影响因素分析结果显示腹水endocan为SBP的独立危险因素[OR=1.008(95%CI为1.004~1.012),P<0.001]。ROC曲线分析显示腹水endocan诊断SBP的曲线下面积(AUC)为0.822(P<0.001),临界值为280.983pg/ml时敏感性为88.57%,特异性为70.63%,在年龄大于等于60岁和小于60岁患者中,腹水endocan诊断SBP的AUC分别为0.852和0.789。结论腹水endocan水平是肝硬化腹水患者SBP的独立危险因素,是SBP有价值的诊断指标,且在年龄大于等于60岁患者的诊断价值更大。
基金supported by the Central Public Interest Scientific Institution Basal Research Fund of China National Rice Research Institute(Grant No.2017RG002-4)the Agricultural Science and Technology Innovation Program of Chinese Academy of Agricultural Sciences,and Science,Technology and Innovation Committee of Shenzhen Municipality(Grant Nos.JCYJ20170303154506881 and JCYJ20170412155447658).
文摘Anthocyanins are widely distributed in one or more parts of rice(Oryza sativa L.)plants,including seed coat,stigma,apiculus,leaf sheath and leaf blade,and are the main pigments used in rice to achieve different colors(Hou et al,2009;Aizza and Dornelas,2011).In rice,tissue-specific color traits(especially the color of apiculus,namely the lemma and palea of the spikelet)are not only important for rice variety identification but also important for linkage analysis and rice domestication research(Saitoh et al,2004;Fan et al,2007;Lin et al,2019).The apiculus color is controlled by the complementary functions of three pairs of dominant genes,C,A and P.Gene C(chromogen)is a pigment gene,which is the basic gene for producing pigments.Gene A(activator)activates gene C,converting the chromogen into anthocyanins,and gene P(purple)controls the distribution of anthocyanins in various organs(Reddy,1996;Sakamoto et al,2001).
