基金This work was supported by the National Key Research and Development Program of China(No.2018YFB1004901)the Natural Science Foundation(No.LY20F020019+3 种基金LQ19F020012LQ20F020001)Basic Public Welfare Research Project(No.LGF19E050005)Major Scientific Research Project of Zhejiang Lab(No.2019MC0AD01)of Zhejiang Province,China。