目的:探讨血清白介素(interleukin,IL)-9水平在急性脑梗死早期神经功能恶化(early neurological deterioration,END)患者血清中的变化并评估其对END的预测价值。方法:收集106例脑梗死患者,根据是否发生END,将患者分为END组42例,非END组6...目的:探讨血清白介素(interleukin,IL)-9水平在急性脑梗死早期神经功能恶化(early neurological deterioration,END)患者血清中的变化并评估其对END的预测价值。方法:收集106例脑梗死患者,根据是否发生END,将患者分为END组42例,非END组64例,收集患者的一般资料,并记录入院时美国国立卫生院神经功能缺损(National Institute of Health stroke scale,NIHSS)评分,检测血清生化指标、基线期血清IL-9、C反应蛋白(C-reactive protein,CRP)和IL-6水平。相关性的评估采用Pearson或Spearman相关性分析,采用Logistic回归分析脑梗死患者发生END的影响因素,并绘制受试者工作特征(receiver operating characteristic,ROC)曲线评估血清IL-9水平在脑梗死后发生END中的预测价值。结果:END组糖尿病比例、颈动脉狭窄>50%比例、低密度脂蛋白胆固醇、糖化血红蛋白、脑梗死体积和入院时NIHSS评分均高于非END组(P<0.05)。END组血清IL-9水平明显高于非END组(P<0.01)。脑梗死患者血清IL-9水平与入院时NIHSS评分呈正相关(r=0.535,P<0.01)。Logistic回归显示血清IL-9水平、颈动脉狭窄>50%、脑梗死体积和入院时NIHSS评分为END发生的危险因素(P<0.01)。血清IL-9水平预测END发生的ROC曲线下面积为0.815。血清IL-9水平与血清CRP水平(r=0.648,P<0.01)和IL-6水平(r=0.765,P<0.01)均呈正相关。结论:血清IL-9水平在脑梗死END患者中明显升高,对END的发生具有良好的预测作用。展开更多
目的研究衢枳壳黄酮(pure total flavonoids from Qu Aurantii Fructus,PTFC)对高脂血症金黄地鼠降血脂作用并初步探讨其潜在机制。方法 48只金黄地鼠随机分为6组(n=8):正常组,模型组,非诺贝特阳性对照组(100 mg·kg-1·d-1),P...目的研究衢枳壳黄酮(pure total flavonoids from Qu Aurantii Fructus,PTFC)对高脂血症金黄地鼠降血脂作用并初步探讨其潜在机制。方法 48只金黄地鼠随机分为6组(n=8):正常组,模型组,非诺贝特阳性对照组(100 mg·kg-1·d-1),PTFC低、中、高剂量组(25,50,100 mg·kg-1·d-1)。高脂饮食喂养金黄地鼠6周,并于第3周起同时给予药物灌胃干预,连续干预4周。高脂饲料喂养造模6周末,处死大鼠,称量大鼠体质量及肝脏质量计算肝脏指数,生化法及ELISA法检测血清生化及炎症指标,血清及肝组织MDA含量和SOD活性。HE染色检测肝脏组织病理学改变,qRT-PCR及Westernblotting检测肝脏及脂肪组织PPAR-α、PPAR-γ的mRNA及蛋白表达。结果与高脂血症模型组金黄地鼠相比,PTFC中、高剂量组的金黄地鼠血清TC、TG、LDL-c、IL-6、TNF-α水平显著下降(P<0.05或P<0.01);PTFC高剂量组血清ALT、AST、GLU水平均明显下降(P<0.05或P<0.01);PTFC低、中、高剂量组金黄地鼠的血清、肝脏SOD活性均显著增强,MDA含量则显著降低(P<0.01)。HE染色显示,与模型组比较,各用药组金黄地鼠的肝脂肪变性均得到不同程度的改善。qRT-PCR和Western blotting检测结果显示,与模型组相比,PTFC给药低、中、高剂量组金黄地鼠肝脏和脂肪中PPAR-α、PPAR-γ的mRNA和蛋白表达水平也显著升高(P<0.05或P<0.01)。结论 PTFC能够起到降低血脂的作用,其可能是通过改善脂质水平,降低氧化应激和炎症反应,激活PPAR-α、PPAR-γ来实现对高脂血症金黄地鼠脂质代谢的改善作用。展开更多
A high-speed broadband tunable microwave source utilizing the wavelength tunable characteristics of distributed Bragg reflector(DBR) laser is proposed and demonstrated.The wavelength tuning of the laser is achieved in...A high-speed broadband tunable microwave source utilizing the wavelength tunable characteristics of distributed Bragg reflector(DBR) laser is proposed and demonstrated.The wavelength tuning of the laser is achieved instantaneously by controlling the voltage of the phase section of the DBR laser.By means of optical delay self-heterodyne technology,the microwave signal with the property of frequency broadband tuning is generated.Sweep speeds of 5 and 40 μs of the sweep-frequency source prototype were achieved and the maximum tuning range was up to 38.45 GHz.展开更多
文摘目的:探讨血清白介素(interleukin,IL)-9水平在急性脑梗死早期神经功能恶化(early neurological deterioration,END)患者血清中的变化并评估其对END的预测价值。方法:收集106例脑梗死患者,根据是否发生END,将患者分为END组42例,非END组64例,收集患者的一般资料,并记录入院时美国国立卫生院神经功能缺损(National Institute of Health stroke scale,NIHSS)评分,检测血清生化指标、基线期血清IL-9、C反应蛋白(C-reactive protein,CRP)和IL-6水平。相关性的评估采用Pearson或Spearman相关性分析,采用Logistic回归分析脑梗死患者发生END的影响因素,并绘制受试者工作特征(receiver operating characteristic,ROC)曲线评估血清IL-9水平在脑梗死后发生END中的预测价值。结果:END组糖尿病比例、颈动脉狭窄>50%比例、低密度脂蛋白胆固醇、糖化血红蛋白、脑梗死体积和入院时NIHSS评分均高于非END组(P<0.05)。END组血清IL-9水平明显高于非END组(P<0.01)。脑梗死患者血清IL-9水平与入院时NIHSS评分呈正相关(r=0.535,P<0.01)。Logistic回归显示血清IL-9水平、颈动脉狭窄>50%、脑梗死体积和入院时NIHSS评分为END发生的危险因素(P<0.01)。血清IL-9水平预测END发生的ROC曲线下面积为0.815。血清IL-9水平与血清CRP水平(r=0.648,P<0.01)和IL-6水平(r=0.765,P<0.01)均呈正相关。结论:血清IL-9水平在脑梗死END患者中明显升高,对END的发生具有良好的预测作用。
基金supported by the National Basic Research Program of China ("973" Project) (Grant Nos. 2012CB315702, 2012CB315703)the National Natural Science Foundation of China (Grant Nos. 61090390,61275078)the Foundation for Innovative Research Groups of the National Natural Science Foundation of China (Grant No. 61021003)
文摘A high-speed broadband tunable microwave source utilizing the wavelength tunable characteristics of distributed Bragg reflector(DBR) laser is proposed and demonstrated.The wavelength tuning of the laser is achieved instantaneously by controlling the voltage of the phase section of the DBR laser.By means of optical delay self-heterodyne technology,the microwave signal with the property of frequency broadband tuning is generated.Sweep speeds of 5 and 40 μs of the sweep-frequency source prototype were achieved and the maximum tuning range was up to 38.45 GHz.
