[ Objective] To study the effects of different oligosaccharides on immunity and production performance of piglets.[ Method] A total of 75 Yorkshire x Rongchang piglets were assigned into five groups, 15 in each group....[ Objective] To study the effects of different oligosaccharides on immunity and production performance of piglets.[ Method] A total of 75 Yorkshire x Rongchang piglets were assigned into five groups, 15 in each group. Isomalto-oligosaccharide （ IMO）, fructo-oligosaccharide （ FOS）, mannan-oligosacchadde （MOS）, and mixed oligosacchadde were supplemented to basal diet （7.5 g/kg）, respectively. The control group was also set. The experimental period lasted for 53 d. The clinic symptoms and diarrhea were observed. All piglets were weighed once a week. Feed intake was also recorded. Blood was collected via precaval vein for determination of immunology indexes at the age of 30 and 60 d, respectively. [ Result] The IMO and FOS enhanced cellular immunity of 30-day-old piglets significantly （P 〈 0.05）, and the IMO also enhanced their humoral immunity. The MOS enhanced cellular immunity and humoral immunity of 60-day-old piglets significantly （P 〈 0.05）. It also improved production performance largest, and its diarrhea rate was the lowest. [ Conclusion] Different oligosaccharides have various effects on immunity and production performance of oiolets.展开更多
A series of novel pyrano[2,3-d]trizaole compounds were synthesized and theirα-glucosidase inhibitory activities were evaluated by in vitro enzyme assay.The experimental data demonstrated that compound 10 f showed up ...A series of novel pyrano[2,3-d]trizaole compounds were synthesized and theirα-glucosidase inhibitory activities were evaluated by in vitro enzyme assay.The experimental data demonstrated that compound 10 f showed up to 10-fold higher inhibition(IC5074.0±1.3μmol·L-1)than acarbose.The molecular docking revealed that compound 10 f could bind toα-glucosidase via the hydrophobic,π-πstacking,and hydrogen bonding interactions.The results may benefit further structural modifications to find new and potentα-glucosidase inhibitors.展开更多
INTRODUCTION End-stage heart disease is the late stage of heart disease caused by a variety of reasons.It refers to the developmental stage of heart disease in which the patient has progressive structural heart diseas...INTRODUCTION End-stage heart disease is the late stage of heart disease caused by a variety of reasons.It refers to the developmental stage of heart disease in which the patient has progressive structural heart disease,despite active medical treatment.Patient with this disease still has symptoms at rest,and requires special intervention.展开更多
基金funded by the Technology Programme Project of Zhongshan City (China) (20073A159)the Open Project of the Key Laboratory of Animal Nutrition and Feed of Yunnan Province
文摘[ Objective] To study the effects of different oligosaccharides on immunity and production performance of piglets.[ Method] A total of 75 Yorkshire x Rongchang piglets were assigned into five groups, 15 in each group. Isomalto-oligosaccharide （ IMO）, fructo-oligosaccharide （ FOS）, mannan-oligosacchadde （MOS）, and mixed oligosacchadde were supplemented to basal diet （7.5 g/kg）, respectively. The control group was also set. The experimental period lasted for 53 d. The clinic symptoms and diarrhea were observed. All piglets were weighed once a week. Feed intake was also recorded. Blood was collected via precaval vein for determination of immunology indexes at the age of 30 and 60 d, respectively. [ Result] The IMO and FOS enhanced cellular immunity of 30-day-old piglets significantly （P 〈 0.05）, and the IMO also enhanced their humoral immunity. The MOS enhanced cellular immunity and humoral immunity of 60-day-old piglets significantly （P 〈 0.05）. It also improved production performance largest, and its diarrhea rate was the lowest. [ Conclusion] Different oligosaccharides have various effects on immunity and production performance of oiolets.
基金the National Key R&D Program of China(No.2018YF-A0507602)the National Natural Science Foundation of China(Nos.81821004 and21738001)。
文摘A series of novel pyrano[2,3-d]trizaole compounds were synthesized and theirα-glucosidase inhibitory activities were evaluated by in vitro enzyme assay.The experimental data demonstrated that compound 10 f showed up to 10-fold higher inhibition(IC5074.0±1.3μmol·L-1)than acarbose.The molecular docking revealed that compound 10 f could bind toα-glucosidase via the hydrophobic,π-πstacking,and hydrogen bonding interactions.The results may benefit further structural modifications to find new and potentα-glucosidase inhibitors.
基金supported by Guangzhou Science and Technology Plan Project(No.202002020037)。
文摘INTRODUCTION End-stage heart disease is the late stage of heart disease caused by a variety of reasons.It refers to the developmental stage of heart disease in which the patient has progressive structural heart disease,despite active medical treatment.Patient with this disease still has symptoms at rest,and requires special intervention.
