Influence of dosimetric considerations in evaluating second cancer risks in prostate cancer. Material and methods: Fifteen patients in this study suffering from early stage of prostate cancer, each patient underwent t...Influence of dosimetric considerations in evaluating second cancer risks in prostate cancer. Material and methods: Fifteen patients in this study suffering from early stage of prostate cancer, each patient underwent three plans: 1) Three-dimensional conformal radiation therapy (3DCRT), 2) Rotation therapy (Arc therapy), and 3) intensity-modulated radiation therapy (IMRT) plan. Estimate secondary metastasis risk models: Excess Relative Risk (ERR) and Excess absolute risk (EAR) based on age of exposure by taking dosimetry data from Dose Volume Histograms (DVHs) to calculate risk models. Result: The second cancer risk models (ERR and EAR) for organs at risk OARs decrease with increasing age of exposure for 3D-CRT, ARC and IMRT and there is no significant difference for ERR and EAR model for developing second cancer risk in 3D-CRT, ARC and IMRT.展开更多
Influence of distinct radiotherapy techniques to induce second cancer risks in left breast cancer. Material and methods: Ten female patients with intact left breast cancer. Two treatment plans for each patient: 1) two...Influence of distinct radiotherapy techniques to induce second cancer risks in left breast cancer. Material and methods: Ten female patients with intact left breast cancer. Two treatment plans for each patient: 1) two tangential beams 3D-Conformal radiotherapy, 2) intensity-modulated radiotherapy (IMRT) plan. Estimation of second cancer risk from Organ equivalent dose models (OEDs) in three dose-response model for organs at risk in left breast cases. Results: The P-value for OED models in 3D-IMRT for left lung, both lung, heart, right lung, right breast, thyroid, liver and spinal cord in linear dose model was 0.016, 0.005, 0.019, 3.95E-06, 5.79E-07, 0.003, 1.78E-10 and 0.000206475 respectively, for linear exponential dose model 0.0577, 0.024, 0.031, 3.40E-06, 3.28E-07, 0.003, 2.01E-10 and 0.000120072 respectively and in plateau dose model 0.088, 0.042, 0.039, 3.18E-06, 2.53E-07, 0.003, 2.27E-10 and 9.00535E-05 respectively. Conclusion: organ equivalent dose models for organs at risk increasing in IMRT than tangential beams.展开更多
文摘Influence of dosimetric considerations in evaluating second cancer risks in prostate cancer. Material and methods: Fifteen patients in this study suffering from early stage of prostate cancer, each patient underwent three plans: 1) Three-dimensional conformal radiation therapy (3DCRT), 2) Rotation therapy (Arc therapy), and 3) intensity-modulated radiation therapy (IMRT) plan. Estimate secondary metastasis risk models: Excess Relative Risk (ERR) and Excess absolute risk (EAR) based on age of exposure by taking dosimetry data from Dose Volume Histograms (DVHs) to calculate risk models. Result: The second cancer risk models (ERR and EAR) for organs at risk OARs decrease with increasing age of exposure for 3D-CRT, ARC and IMRT and there is no significant difference for ERR and EAR model for developing second cancer risk in 3D-CRT, ARC and IMRT.
文摘Influence of distinct radiotherapy techniques to induce second cancer risks in left breast cancer. Material and methods: Ten female patients with intact left breast cancer. Two treatment plans for each patient: 1) two tangential beams 3D-Conformal radiotherapy, 2) intensity-modulated radiotherapy (IMRT) plan. Estimation of second cancer risk from Organ equivalent dose models (OEDs) in three dose-response model for organs at risk in left breast cases. Results: The P-value for OED models in 3D-IMRT for left lung, both lung, heart, right lung, right breast, thyroid, liver and spinal cord in linear dose model was 0.016, 0.005, 0.019, 3.95E-06, 5.79E-07, 0.003, 1.78E-10 and 0.000206475 respectively, for linear exponential dose model 0.0577, 0.024, 0.031, 3.40E-06, 3.28E-07, 0.003, 2.01E-10 and 0.000120072 respectively and in plateau dose model 0.088, 0.042, 0.039, 3.18E-06, 2.53E-07, 0.003, 2.27E-10 and 9.00535E-05 respectively. Conclusion: organ equivalent dose models for organs at risk increasing in IMRT than tangential beams.
