Coronavirus has a lipid membrane.Whist replication requires hijacking the RNA tools of the host to synthesize virion protein,that then has to be wrapped in a lipid membrane to enable the budding off which extends the ...Coronavirus has a lipid membrane.Whist replication requires hijacking the RNA tools of the host to synthesize virion protein,that then has to be wrapped in a lipid membrane to enable the budding off which extends the infection.Recent studies implicate certain essential fatty acids with replication suppression properties.The lipid membrane is commonly thought of as a fatty barrier to water solubles.It is however highly ordered and compositionally specific to cellular and sub cellular functions.There will likely also be an optimum specificity for the viral coat.Whist DNA,RNA and protein compositions are not affected by diet,the lipid membrane is.Moreover,the greater sensitivity of males over females to inadequacy of these essential fatty acids and membrane integrity has been known since the 1960 s.With evidence that arachidonic and docosahexaenoic acids exhibiting anti-viral,immune,anti-inflammatory,blood pressure control and resolvin activity,their status needs to be urgently examined in relation to the prevention and therapy for Covid-19.It would also be advisable to re-assess food policy.The lipid requirements for the membrane rich systems as in the brain,nervous,vascular and immune systems have not been considered.There is little doubt these were significant in shaping the human genome over several million years.Departure from such conditions would be predicted to put populations at risk to disorder and infection,with males being more at risk than females.展开更多
Excessive use of maleic anhydride(MAN)in starch production is potentially harmful for consumers’health.This study presents a macro-scale Raman chemical imaging method for detection and quantification of MAN particles...Excessive use of maleic anhydride(MAN)in starch production is potentially harmful for consumers’health.This study presents a macro-scale Raman chemical imaging method for detection and quantification of MAN particles mixed in starch powder.MAN was mixed into corn starch at eight concentration levels from 50 ppm to 6400 ppm(w/w).Each mixture was put in a sample holder with a 150 mm×100 mm area and a 2 mm depth to create a large surface and a thin layer of the powdery sample for inspection.A 30 W 785 nm line laser was projected on the sample surface,from which hyperspectral images were obtained by a line-scan Raman imaging system with a spatial resolution of 0.2 mm.Fluorescence signals generated by laser-sample interactions were eliminated by a mathematical baseline correction method.A unique Raman peak was selected at 1839 cm-1 for the MAN detection,at which single-band fluorescence-corrected images were extracted from the mixture of each concentration and used to generate chemical images for MAN detection and mapping.The MAN detection limit was estimated at 100 ppm based on the Raman imaging measurement results.Pixel concentrations of the MAN in the chemical images were found linearly correlated with mass concentrations of the MAN particles in the starch powder,suggesting the Raman chemical imaging method has the potential for quantitative detection of the MAN in the starch-MAN mixtures.展开更多
基金funded by the Mother and ChildThe Letten+1 种基金Waterloo FoundationsBorne
文摘Coronavirus has a lipid membrane.Whist replication requires hijacking the RNA tools of the host to synthesize virion protein,that then has to be wrapped in a lipid membrane to enable the budding off which extends the infection.Recent studies implicate certain essential fatty acids with replication suppression properties.The lipid membrane is commonly thought of as a fatty barrier to water solubles.It is however highly ordered and compositionally specific to cellular and sub cellular functions.There will likely also be an optimum specificity for the viral coat.Whist DNA,RNA and protein compositions are not affected by diet,the lipid membrane is.Moreover,the greater sensitivity of males over females to inadequacy of these essential fatty acids and membrane integrity has been known since the 1960 s.With evidence that arachidonic and docosahexaenoic acids exhibiting anti-viral,immune,anti-inflammatory,blood pressure control and resolvin activity,their status needs to be urgently examined in relation to the prevention and therapy for Covid-19.It would also be advisable to re-assess food policy.The lipid requirements for the membrane rich systems as in the brain,nervous,vascular and immune systems have not been considered.There is little doubt these were significant in shaping the human genome over several million years.Departure from such conditions would be predicted to put populations at risk to disorder and infection,with males being more at risk than females.
文摘Excessive use of maleic anhydride(MAN)in starch production is potentially harmful for consumers’health.This study presents a macro-scale Raman chemical imaging method for detection and quantification of MAN particles mixed in starch powder.MAN was mixed into corn starch at eight concentration levels from 50 ppm to 6400 ppm(w/w).Each mixture was put in a sample holder with a 150 mm×100 mm area and a 2 mm depth to create a large surface and a thin layer of the powdery sample for inspection.A 30 W 785 nm line laser was projected on the sample surface,from which hyperspectral images were obtained by a line-scan Raman imaging system with a spatial resolution of 0.2 mm.Fluorescence signals generated by laser-sample interactions were eliminated by a mathematical baseline correction method.A unique Raman peak was selected at 1839 cm-1 for the MAN detection,at which single-band fluorescence-corrected images were extracted from the mixture of each concentration and used to generate chemical images for MAN detection and mapping.The MAN detection limit was estimated at 100 ppm based on the Raman imaging measurement results.Pixel concentrations of the MAN in the chemical images were found linearly correlated with mass concentrations of the MAN particles in the starch powder,suggesting the Raman chemical imaging method has the potential for quantitative detection of the MAN in the starch-MAN mixtures.
