2-Arylbenzothiazoles formed in good yields（65-90%） by the condensation of aminothiophenols with aromatic aldehydes using P_2O_5 at ambient temperature.
A new series of 1H-pyrazole derivatives 5a-j bearing an aryl sulfonate moiety have been synthesized by a one-pot cyclo-condensation reaction of 2-（3-（dimethylamino）acryloyl）phenyl-4-methyl benzene sulfonates 4a-e ...A new series of 1H-pyrazole derivatives 5a-j bearing an aryl sulfonate moiety have been synthesized by a one-pot cyclo-condensation reaction of 2-（3-（dimethylamino）acryloyl）phenyl-4-methyl benzene sulfonates 4a-e and hydrazine hydrate or phenyl hydrazine in ethanol under reflux conditions. Some of the newly synthesized compounds were screened for their anti-inflammatory activity. All synthesized compounds were screened against Gram positive and Gram negative bacterial and fungal strains. The compound 5b was found to be a potent anti-inflammatory agent while the majority of the compounds were found to be active against microbial strains.展开更多
基金the financial support from Department of Science and Technology,New Delhi under Fast Track Young Scientist programme(No.SR/FTP/CS-82/2007).
文摘2-Arylbenzothiazoles formed in good yields（65-90%） by the condensation of aminothiophenols with aromatic aldehydes using P_2O_5 at ambient temperature.
文摘A new series of 1H-pyrazole derivatives 5a-j bearing an aryl sulfonate moiety have been synthesized by a one-pot cyclo-condensation reaction of 2-（3-（dimethylamino）acryloyl）phenyl-4-methyl benzene sulfonates 4a-e and hydrazine hydrate or phenyl hydrazine in ethanol under reflux conditions. Some of the newly synthesized compounds were screened for their anti-inflammatory activity. All synthesized compounds were screened against Gram positive and Gram negative bacterial and fungal strains. The compound 5b was found to be a potent anti-inflammatory agent while the majority of the compounds were found to be active against microbial strains.
