On August 7,2023,Mangshi City,Dehong Prefecture experienced a local heavy rainstorm,and the geological disaster caused by the heavy rainfall caused casualties and property losses.Based on the real-time observation dat...On August 7,2023,Mangshi City,Dehong Prefecture experienced a local heavy rainstorm,and the geological disaster caused by the heavy rainfall caused casualties and property losses.Based on the real-time observation data of automatic stations,Doppler weather radar detection and meteorological risk warning products,the disaster situation,social impact,forecast and early warning service,causes of heavy precipitation and forecast and early warning inspection were summarized and analyzed.The results show that the heavy rainfall was prominent locally,lasted for a long time and accumulated a large amount of rainfall.There were biases in model products,and it was difficult for forecasters to make subjective corrections in complex terrain.The analysis ideas and focus points of heavy rainfall forecast,the improvement ideas and technical schemes of forecast deviation,and the improvement ideas and suggestions of services were summarized.It provides a reference for the forecast and early warning of severe weather in the future.展开更多
Ginsenoside Rg1(GR),a major bioactive compound of traditional Chinese medicine,such as Panax ginseng or Radix Notoginseng,has been shown to exert neuroprotective effects against ischemic stroke.However,pharmacokinetic...Ginsenoside Rg1(GR),a major bioactive compound of traditional Chinese medicine,such as Panax ginseng or Radix Notoginseng,has been shown to exert neuroprotective effects against ischemic stroke.However,pharmacokinetic studies have suggested that GR could not be efficiently transported through the blood–brain barrier.The mechanism by which GR attenuates cerebral ischemic injury in vivo remains largely unknown.Therefore,this study explored potential neuro-protective effects of GR through its systemic metabolic regulating mechanism by using mass spectrometry–based metabolomic profiling.Rats with middle cerebral artery occlusion(MCAO) were treated with GR intravenously.Their metabolic profiles in serum were measured by gas chromatography coupled with mass spectrometry on 1 and 3 days after MCAO.GR exhibited a potent neuro-protective effect by significantly decreasing the neurological scores and infarct volume in the MCAO rats.Moreover,18 differential metabolites were tentatively identified,all of which appeared to correlate well with these disease indices.Our findings suggested that GR carries a therapeutic potential in stroke possibly through a feed-back mechanism by regulating systematic metabolic mediation.展开更多
基金Supported by the Research on the Spatial and Temporal Characteristics and Occurrence Mechanism of Rainstorm in Dehong (STIAP202244)Key Laboratory of Heavy Rainfall in River Basins,China Meteorological Administration (2023BHR-Y09)+1 种基金Project of Key Laboratory of Hydrometeorology,China Meteorological Administration (23SWQXZ009)National Natural Science Foundation of China (42075013,41765003,41665005).
文摘On August 7,2023,Mangshi City,Dehong Prefecture experienced a local heavy rainstorm,and the geological disaster caused by the heavy rainfall caused casualties and property losses.Based on the real-time observation data of automatic stations,Doppler weather radar detection and meteorological risk warning products,the disaster situation,social impact,forecast and early warning service,causes of heavy precipitation and forecast and early warning inspection were summarized and analyzed.The results show that the heavy rainfall was prominent locally,lasted for a long time and accumulated a large amount of rainfall.There were biases in model products,and it was difficult for forecasters to make subjective corrections in complex terrain.The analysis ideas and focus points of heavy rainfall forecast,the improvement ideas and technical schemes of forecast deviation,and the improvement ideas and suggestions of services were summarized.It provides a reference for the forecast and early warning of severe weather in the future.
基金supported by research grants from the National Twelfth-Five Year Research Program of China (No.2012ZX093-01002001002)the National Natural Science Foundation of China (No.81473398)
文摘Ginsenoside Rg1(GR),a major bioactive compound of traditional Chinese medicine,such as Panax ginseng or Radix Notoginseng,has been shown to exert neuroprotective effects against ischemic stroke.However,pharmacokinetic studies have suggested that GR could not be efficiently transported through the blood–brain barrier.The mechanism by which GR attenuates cerebral ischemic injury in vivo remains largely unknown.Therefore,this study explored potential neuro-protective effects of GR through its systemic metabolic regulating mechanism by using mass spectrometry–based metabolomic profiling.Rats with middle cerebral artery occlusion(MCAO) were treated with GR intravenously.Their metabolic profiles in serum were measured by gas chromatography coupled with mass spectrometry on 1 and 3 days after MCAO.GR exhibited a potent neuro-protective effect by significantly decreasing the neurological scores and infarct volume in the MCAO rats.Moreover,18 differential metabolites were tentatively identified,all of which appeared to correlate well with these disease indices.Our findings suggested that GR carries a therapeutic potential in stroke possibly through a feed-back mechanism by regulating systematic metabolic mediation.
