Background:This study aimed to assess the performance of transient elastography(TE),two-dimensional shear wave elastography(2D-SWE),and magnetic resonance elastography(MRE)for staging significant fibrosis and cirrhosi...Background:This study aimed to assess the performance of transient elastography(TE),two-dimensional shear wave elastography(2D-SWE),and magnetic resonance elastography(MRE)for staging significant fibrosis and cirrhosis in untreated chronic hepatitis B(CHB)patients.Methods:Pubmed,Embase,Web of Science,and Cochrane Library were searched for terms involving CHB,TE,2D-SWE,and MRE.Other etiologies of chronic liver disease,previous treatment in patients,or articles not published in SCI journals were excluded.Hierarchical non-linear models were used to evaluate the diagnostic accuracy of TE,2D-SWE,and MRE.Heterogeneity was explored via analysis of threshold effect and meta-regression.Results:Twenty-eight articles with a total of 4,540 untreated CHB patients were included.The summary areas under the receiver-operating characteristic curves(AUROCs)using TE,2D-SWE,and MRE for predicting significant fibrosis(SF)were 0.84,0.89,and 0.99,respectively.The AUROC values of TE,2D-SWE,and MRE for staging cirrhosis were 0.9,0.94,and 0.99,respectively.Based on the meta-analysis of studies with head-to-head comparison,2D-SWE is superior to TE(0.92 vs 0.85,P<0.01)in staging significant fibrosis.Conclusion:TE,2D-SWE,and MRE express acceptable diagnostic accuracies in staging significant fibrosis and cirrhosis in untreated CHB patients.2D-SWE outperforms TE in detecting significant fibrosis in treatment-naive people with hepatitis B virus.展开更多
基金funding by the National Natural Science Foundation of China[82070574]the Natural Science Foundation Team Project of Guangdong Province[2018B030312009].
文摘Background:This study aimed to assess the performance of transient elastography(TE),two-dimensional shear wave elastography(2D-SWE),and magnetic resonance elastography(MRE)for staging significant fibrosis and cirrhosis in untreated chronic hepatitis B(CHB)patients.Methods:Pubmed,Embase,Web of Science,and Cochrane Library were searched for terms involving CHB,TE,2D-SWE,and MRE.Other etiologies of chronic liver disease,previous treatment in patients,or articles not published in SCI journals were excluded.Hierarchical non-linear models were used to evaluate the diagnostic accuracy of TE,2D-SWE,and MRE.Heterogeneity was explored via analysis of threshold effect and meta-regression.Results:Twenty-eight articles with a total of 4,540 untreated CHB patients were included.The summary areas under the receiver-operating characteristic curves(AUROCs)using TE,2D-SWE,and MRE for predicting significant fibrosis(SF)were 0.84,0.89,and 0.99,respectively.The AUROC values of TE,2D-SWE,and MRE for staging cirrhosis were 0.9,0.94,and 0.99,respectively.Based on the meta-analysis of studies with head-to-head comparison,2D-SWE is superior to TE(0.92 vs 0.85,P<0.01)in staging significant fibrosis.Conclusion:TE,2D-SWE,and MRE express acceptable diagnostic accuracies in staging significant fibrosis and cirrhosis in untreated CHB patients.2D-SWE outperforms TE in detecting significant fibrosis in treatment-naive people with hepatitis B virus.
