BACKGROUND The co-occurrence of Anti-phospholipase A2 receptor-associated membranous nephropathy(anti-PLA2R-MN)and human immunodeficiency virus(HIV)infection is a rare clinical scenario,presenting significant challeng...BACKGROUND The co-occurrence of Anti-phospholipase A2 receptor-associated membranous nephropathy(anti-PLA2R-MN)and human immunodeficiency virus(HIV)infection is a rare clinical scenario,presenting significant challenges in terms of management and treatment.CASE SUMMARY A 32-year-old Chinese male diagnosed with HIV infection presented with a clinical history of proteinuria persisting for over two years.A kidney biopsy demonstrated subepithelial immune complex deposition and a thickened glomerular basement membrane,indicative of stage I-II membranous nephro-pathy.Immunofluorescence staining revealed granular deposition of PLA2R(3+)along the glomerular capillary loops,corroborated by a strongly positive anti-PLA2R antibody test(1:320).Initial treatment involving losartan potassium,rivaroxaban,tacrolimus,and rituximab was discontinued due to either poor effec-tiveness or the occurrence of adverse events.Following a regimen of weekly subcutaneous injections of telitacicept(160 mg),a marked decline in the 24 h urine protein was observed within a three-month period,accompanied by a rise in serum albumin level.No significant reductions in peripheral blood CD3+CD4+T and CD3+CD8+T cell counts were detected.The patient's physical and psychological conditions showed significant improvements,with no adverse events reported during the treatment course.CONCLUSION Telitacicept might offer a potential therapeutic avenue for patients diagnosed with anti-PLA2R-MN concomitant with HIV infection.展开更多
In this paper, we have proposed a novel model called proximal support matrix machine (PSMM), which is mainly based on the models of proximal support vector machine (PSVM) and low rank support matrix machine (LRSMM). I...In this paper, we have proposed a novel model called proximal support matrix machine (PSMM), which is mainly based on the models of proximal support vector machine (PSVM) and low rank support matrix machine (LRSMM). In design, the PSMM model has comprehensively considered both the relationship between samples of the same class and the structure of rows or columns of matrix data. To a certain extent, our novel model can be regarded as a synthesis of the PSVM model and the LRSMM model. Since the PSMM model is an unconstrained convex problem in essence, we have established an alternating direction method of multipliers algorithm to deal with the proposed model. Finally, since a great deal of experiments on the minst digital database show that the PSMM classifier has a good ability to distinguish two digits with little difference, it encourages us to conduct more complex experiments on MIT face database, INRIA person database, the students face database and Japan female facial expression database. Meanwhile, the final experimental results show that PSMM performs better than PSVM, twin support vector machine, LRSMM and linear twin multiple rank support matrix machine in the demanding image classification tasks.展开更多
Microglia-associated neuroinflammation plays an important role in the pathophysiology of ischemic stroke.Microglial activation and polarization,and the inflammatory response mediated by these cells play important role...Microglia-associated neuroinflammation plays an important role in the pathophysiology of ischemic stroke.Microglial activation and polarization,and the inflammatory response mediated by these cells play important roles in the development,progression and outcome of brain injury after ischemic stroke.Currently,there is no effective strategy for treating ischemic stroke in clinical practice.Therefore,it is clinically important to study the role and regulation of microglia in stroke.In this review,we discuss the involvement of microglia in the neuroinflammatory process in ischemic stroke,with the aim of providing a better understanding of the relationship between ischemic stroke and microglia.展开更多
Computational intelligence is one of the most powerful data processing tools to solve complex nonlinear problems,and thus plays a significant role in intelligent fault diagnosis and prediction.However,only few compreh...Computational intelligence is one of the most powerful data processing tools to solve complex nonlinear problems,and thus plays a significant role in intelligent fault diagnosis and prediction.However,only few comprehensive reviews have summarized the ongoing efforts of computational intelligence in machinery condition monitoring and fault diagnosis.The recent research and development of computational intelligence techniques in fault diagnosis,prediction and optimal sensor placement are reviewed.The advantages and limitations of computational intelligence techniques in practical applications are discussed.The characteristics of different algorithms are compared,and application situations of these methods are summarized.Computational intelligence methods need to be further studied in deep understanding algorithm mechanism,improving algorithm efficiency and enhancing engineering application.This review may be considered as a useful guidance for researchers in selecting a suitable method for a specific situation and pointing out potential research directions.展开更多
The simultaneous CO_(2) capture and heat storage performances of the modified carbide slag with byproduct of biodiesel were investigated in the process coupled calcium looping and CaO/Ca(OH)2 thermochemical heat stora...The simultaneous CO_(2) capture and heat storage performances of the modified carbide slag with byproduct of biodiesel were investigated in the process coupled calcium looping and CaO/Ca(OH)2 thermochemical heat storage using air as the heat transfer fluid.The modified carbide slag with by-product of biodiesel exhibits superior CO_(2) capture and heat storage capacities in the coupled calcium looping and heat storage cycles.The hydration conversion and heat storage density of the modified carbide slag after 30 heat storage cycles are 0.65 mol·mol^(-1) and 1.14 GJ·t^(-1),respectively,which are 1.6 times as high as those of calcined carbide slag.The negative effect of CO_(2) in air as the heat storage fluid on the heat storage capacity of the modified carbide slag is overcome by introducing CO_(2) capture cycles.In addition,the CO_(2) capture reactivity of the modified carbide slag after the multiple calcium looping cycles is enhanced by the introduction of heat storage cycles.By introducing 10 heat storage cycles after the 10th and 15th CO_(2) capture cycles,the CO_(2) capture capacities of the modified carbide slag are subsequently improved by 32%and 43%,respectively.The porous and loose structure of modified carbide slag reduces the diffusion resistances of CO_(2) and steam in the material in the coupled process.The formed CaCO_(3)in the modified carbide slag as a result of air as the heat transfer fluid in heat storage cycles decomposes to regenerate CaO in calcium looping cycles,which improves heat storage capacity.Therefore,the modified carbide slag with by-product of biodiesel seems promising in the coupled calcium looping and CaO/Ca(OH)_(2) heat storage cycles.展开更多
Oil and gas pipeline networks are a key link in the coordinated development of oil and gas both upstream and downstream.To improve the reliability and safety of the oil and gas pipeline network, inspections are implem...Oil and gas pipeline networks are a key link in the coordinated development of oil and gas both upstream and downstream.To improve the reliability and safety of the oil and gas pipeline network, inspections are implemented to minimize the risk of leakage, spill and theft, as well as documenting actual incidents. In recent years, unmanned aerial vehicles have been recognized as a promising option for inspection due to their high efficiency. However, the integrated optimization of unmanned aerial vehicle inspection for oil and gas pipeline networks, including physical feasibility, the performance of mission, cooperation, real-time implementation and three-dimensional(3-D) space, is a strategic problem due to its large-scale,complexity as well as the need for efficiency. In this work, a novel mixed-integer nonlinear programming model is proposed that takes into account the constraints of the mission scenario and the safety performance of unmanned aerial vehicles. To minimize the total length of the inspection path, the model is solved by a two-stage solution method. Finally, a virtual pipeline network and a practical pipeline network are set as two examples to demonstrate the performance of the optimization schemes. Moreover, compared with the traditional genetic algorithm and simulated annealing algorithm, the self-adaptive genetic simulated annealing algorithm proposed in this paper provides strong stability.展开更多
Calcium looping realizes CO_(2)capture via the cyclic calcination/carbonation of CaO.The combustion of fuel supplies energy for the calciner.It is unavoidable that some unburned char in the calciner flows into the car...Calcium looping realizes CO_(2)capture via the cyclic calcination/carbonation of CaO.The combustion of fuel supplies energy for the calciner.It is unavoidable that some unburned char in the calciner flows into the carbonator,generating CO due to the hypoxic atmosphere in the carbonator.CO can reduce NO in the flue gases from coal-fired power plants.In this work,NO removal performance of CO in the carbonation stage of calcium looping for CO_(2)capture was investigated in a bubbling fluidized bed reactor.The effects of carbonation temperature,CO concentration,CO_(2)capture,type of CaO,number of CO_(2)capture cycles and presence of char on NO removal by CO in carbonation stage of calcium looping were discussed.CaO possesses an efficient catalytic effect on NO removal by CO.High temperature and high CO concentration lead to high NO removal efficiency of CO in the presence of CaO.Taking account of better NO removal and CO_(2)capture,the optimal carbonation temperature is 650℃.The carbonation of CaO reduces the catalytic activity of CaO for NO removal by CO due to the formation of CaCO_(3).Besides,the catalytic performance of CaO on NO removal by CO gradually decreases with the number of CO_(2)capture cycles.This is because the sintering of CaO leads to the fusion of CaO grains and blockage of pores in CaO,hindering the diffusion of NO and CO.The high CaO content and porous structure of calcium-based sorbents are beneficial for NO removal by CO.The presence of char promotes NO removal by CO in the carbonator.CO_(2)/NO removal efficiencies can reach above 90%.The efficient simultaneous NO and CO_(2)removal by CO and CaO in the carbonation step of the calcium looping seems promising.展开更多
文摘BACKGROUND The co-occurrence of Anti-phospholipase A2 receptor-associated membranous nephropathy(anti-PLA2R-MN)and human immunodeficiency virus(HIV)infection is a rare clinical scenario,presenting significant challenges in terms of management and treatment.CASE SUMMARY A 32-year-old Chinese male diagnosed with HIV infection presented with a clinical history of proteinuria persisting for over two years.A kidney biopsy demonstrated subepithelial immune complex deposition and a thickened glomerular basement membrane,indicative of stage I-II membranous nephro-pathy.Immunofluorescence staining revealed granular deposition of PLA2R(3+)along the glomerular capillary loops,corroborated by a strongly positive anti-PLA2R antibody test(1:320).Initial treatment involving losartan potassium,rivaroxaban,tacrolimus,and rituximab was discontinued due to either poor effec-tiveness or the occurrence of adverse events.Following a regimen of weekly subcutaneous injections of telitacicept(160 mg),a marked decline in the 24 h urine protein was observed within a three-month period,accompanied by a rise in serum albumin level.No significant reductions in peripheral blood CD3+CD4+T and CD3+CD8+T cell counts were detected.The patient's physical and psychological conditions showed significant improvements,with no adverse events reported during the treatment course.CONCLUSION Telitacicept might offer a potential therapeutic avenue for patients diagnosed with anti-PLA2R-MN concomitant with HIV infection.
文摘In this paper, we have proposed a novel model called proximal support matrix machine (PSMM), which is mainly based on the models of proximal support vector machine (PSVM) and low rank support matrix machine (LRSMM). In design, the PSMM model has comprehensively considered both the relationship between samples of the same class and the structure of rows or columns of matrix data. To a certain extent, our novel model can be regarded as a synthesis of the PSVM model and the LRSMM model. Since the PSMM model is an unconstrained convex problem in essence, we have established an alternating direction method of multipliers algorithm to deal with the proposed model. Finally, since a great deal of experiments on the minst digital database show that the PSMM classifier has a good ability to distinguish two digits with little difference, it encourages us to conduct more complex experiments on MIT face database, INRIA person database, the students face database and Japan female facial expression database. Meanwhile, the final experimental results show that PSMM performs better than PSVM, twin support vector machine, LRSMM and linear twin multiple rank support matrix machine in the demanding image classification tasks.
基金supported by the National Natural Science Foundation of China(21603134)Young Talent Fund of University Association for Science and Technology in Shaanxi,China(20150104)+1 种基金Natural Science Basic Research Plan in Shaanxi Province of China(2016JQ2023)the Fundamental Research Funds for the Central Universities(GK201603032)~~
基金This work was supported by the National Natural Science Foundation of China,Nos.31871169(to YT),81600040(to APW)Key Project of Department of Education of Hunan Province,China,No.18A243(to APW)+1 种基金Innovation Guidance Project of Hunan Province,China,No.2018SK51606(to SXG)the Natural Science Foundation of Hunan Province of China,No.2017JJ3279(to APW).
文摘Microglia-associated neuroinflammation plays an important role in the pathophysiology of ischemic stroke.Microglial activation and polarization,and the inflammatory response mediated by these cells play important roles in the development,progression and outcome of brain injury after ischemic stroke.Currently,there is no effective strategy for treating ischemic stroke in clinical practice.Therefore,it is clinically important to study the role and regulation of microglia in stroke.In this review,we discuss the involvement of microglia in the neuroinflammatory process in ischemic stroke,with the aim of providing a better understanding of the relationship between ischemic stroke and microglia.
基金Supported by National Natural Science Foundation of China(Grant No.51675098)
文摘Computational intelligence is one of the most powerful data processing tools to solve complex nonlinear problems,and thus plays a significant role in intelligent fault diagnosis and prediction.However,only few comprehensive reviews have summarized the ongoing efforts of computational intelligence in machinery condition monitoring and fault diagnosis.The recent research and development of computational intelligence techniques in fault diagnosis,prediction and optimal sensor placement are reviewed.The advantages and limitations of computational intelligence techniques in practical applications are discussed.The characteristics of different algorithms are compared,and application situations of these methods are summarized.Computational intelligence methods need to be further studied in deep understanding algorithm mechanism,improving algorithm efficiency and enhancing engineering application.This review may be considered as a useful guidance for researchers in selecting a suitable method for a specific situation and pointing out potential research directions.
基金supported by the National Natural Science Foun-dation of China(51876105)the Fundamental Research Funds of Shandong University(2018JC039).
文摘The simultaneous CO_(2) capture and heat storage performances of the modified carbide slag with byproduct of biodiesel were investigated in the process coupled calcium looping and CaO/Ca(OH)2 thermochemical heat storage using air as the heat transfer fluid.The modified carbide slag with by-product of biodiesel exhibits superior CO_(2) capture and heat storage capacities in the coupled calcium looping and heat storage cycles.The hydration conversion and heat storage density of the modified carbide slag after 30 heat storage cycles are 0.65 mol·mol^(-1) and 1.14 GJ·t^(-1),respectively,which are 1.6 times as high as those of calcined carbide slag.The negative effect of CO_(2) in air as the heat storage fluid on the heat storage capacity of the modified carbide slag is overcome by introducing CO_(2) capture cycles.In addition,the CO_(2) capture reactivity of the modified carbide slag after the multiple calcium looping cycles is enhanced by the introduction of heat storage cycles.By introducing 10 heat storage cycles after the 10th and 15th CO_(2) capture cycles,the CO_(2) capture capacities of the modified carbide slag are subsequently improved by 32%and 43%,respectively.The porous and loose structure of modified carbide slag reduces the diffusion resistances of CO_(2) and steam in the material in the coupled process.The formed CaCO_(3)in the modified carbide slag as a result of air as the heat transfer fluid in heat storage cycles decomposes to regenerate CaO in calcium looping cycles,which improves heat storage capacity.Therefore,the modified carbide slag with by-product of biodiesel seems promising in the coupled calcium looping and CaO/Ca(OH)_(2) heat storage cycles.
基金part of the Program of "Study on Optimization and Supply-side Reliability of Oil Product Supply Chain Logistics System" funded under the National Natural Science Foundation of China, Grant Number 51874325
文摘Oil and gas pipeline networks are a key link in the coordinated development of oil and gas both upstream and downstream.To improve the reliability and safety of the oil and gas pipeline network, inspections are implemented to minimize the risk of leakage, spill and theft, as well as documenting actual incidents. In recent years, unmanned aerial vehicles have been recognized as a promising option for inspection due to their high efficiency. However, the integrated optimization of unmanned aerial vehicle inspection for oil and gas pipeline networks, including physical feasibility, the performance of mission, cooperation, real-time implementation and three-dimensional(3-D) space, is a strategic problem due to its large-scale,complexity as well as the need for efficiency. In this work, a novel mixed-integer nonlinear programming model is proposed that takes into account the constraints of the mission scenario and the safety performance of unmanned aerial vehicles. To minimize the total length of the inspection path, the model is solved by a two-stage solution method. Finally, a virtual pipeline network and a practical pipeline network are set as two examples to demonstrate the performance of the optimization schemes. Moreover, compared with the traditional genetic algorithm and simulated annealing algorithm, the self-adaptive genetic simulated annealing algorithm proposed in this paper provides strong stability.
基金Financial supports from the National Natural Science Foundation of China(51876105)the Joint Foundation of National Natural Science Foundation of China and Shanxi Province for coal-based low carbon(U1510130)+2 种基金Shandong Provincial Natural Science Foundation(ZR2020ME188)the Fundamental Research Funds of Shandong University(2018JC039)the program for Outstanding PhD candidate of Shandong University。
文摘Calcium looping realizes CO_(2)capture via the cyclic calcination/carbonation of CaO.The combustion of fuel supplies energy for the calciner.It is unavoidable that some unburned char in the calciner flows into the carbonator,generating CO due to the hypoxic atmosphere in the carbonator.CO can reduce NO in the flue gases from coal-fired power plants.In this work,NO removal performance of CO in the carbonation stage of calcium looping for CO_(2)capture was investigated in a bubbling fluidized bed reactor.The effects of carbonation temperature,CO concentration,CO_(2)capture,type of CaO,number of CO_(2)capture cycles and presence of char on NO removal by CO in carbonation stage of calcium looping were discussed.CaO possesses an efficient catalytic effect on NO removal by CO.High temperature and high CO concentration lead to high NO removal efficiency of CO in the presence of CaO.Taking account of better NO removal and CO_(2)capture,the optimal carbonation temperature is 650℃.The carbonation of CaO reduces the catalytic activity of CaO for NO removal by CO due to the formation of CaCO_(3).Besides,the catalytic performance of CaO on NO removal by CO gradually decreases with the number of CO_(2)capture cycles.This is because the sintering of CaO leads to the fusion of CaO grains and blockage of pores in CaO,hindering the diffusion of NO and CO.The high CaO content and porous structure of calcium-based sorbents are beneficial for NO removal by CO.The presence of char promotes NO removal by CO in the carbonator.CO_(2)/NO removal efficiencies can reach above 90%.The efficient simultaneous NO and CO_(2)removal by CO and CaO in the carbonation step of the calcium looping seems promising.
