The development of Pudong hasattracted worldwide attention whilePudong’s "face", the Lujiazui Financeand Trade Zone, is more striking. Hundredsof tall buildings have sprung up likemushrooms in Pudong; the g...The development of Pudong hasattracted worldwide attention whilePudong’s "face", the Lujiazui Financeand Trade Zone, is more striking. Hundredsof tall buildings have sprung up likemushrooms in Pudong; the grand YangpuBridge and Nanpu Bridge cross the HuangpuRiver, setting each other off fantasticallywith the imposing Oriental Pearl TV Towernearby; the broad avenue traverses the zonelike a rainbow; the new Shanghai CommerceCity is emerging on the horizon,展开更多
文摘目的探讨利拉鲁肽基于核因子κB(nuclear factor-κB,NF-κB)/核苷酸结合寡聚化结构域样受体蛋白(nucleotide-binding oligomerization domain-like receptor protein 3,NLRP3)通路对超重/肥胖糖尿病前期患者的作用。方法选取2020年4月至2021年3月杭州市中医院收治的超重/肥胖糖尿病前期患者60例,根据随机数字表法将其分为对照组和观察组,每组各30例。对照组患者进行生活方式干预,观察组患者在此基础上给予利拉鲁肽皮下注射。两组患者均干预12周。比较两组患者干预前后的体质量指数(body mass index,BMI)、血糖相关指标[糖化血红蛋白(glycosylated hemoglobin,HbA1c)、空腹血糖(fasting blood glucose,FBG)、餐后2h血糖(2h postprandial blood glucose,2hPBG)、空腹胰岛素(fasting insulin,FINS)、餐后2h胰岛素(2h postprandial insulin,2hPINS)、稳态模型评估的胰岛素抵抗(homeostasis model assessment of insulin resistance,HOMA-IR)指数]、血脂指标[三酰甘油(triglyceride,TG)、总胆固醇(total cholesterol,TC)、高密度脂蛋白胆固醇(high density lipoprotein-cholesterol,HDL-C)、低密度脂蛋白胆固醇(low density lipoprotein-cholesterol,LDL-C)]、炎症因子[白细胞介素(interleukin,IL)-1β、IL-6、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)]、NF-κB、NLRP3蛋白表达水平。结果观察组患者的BMI、FBG、2hPBG、FINS、2hPINS、HbA1c、HOMA-IR指数、TG、TC、LDL-C、IL-6、IL-1β、TNF-α及NF-κB、NLRP3蛋白表达水平均显著低于同期对照组(P<0.05),HDL-C显著高于同期对照组(P<0.05)。观察组患者的IL-6、IL-1β、TNF-α与HOMA-IR指数均呈正相关(r=0.615,0.327,0.343,P<0.05)。结论利拉鲁肽通过抑制NF-κB/NLRP3通路减轻炎症反应,可降低超重/肥胖糖尿病前期患者的体质量,改善糖脂代谢紊乱。
文摘The development of Pudong hasattracted worldwide attention whilePudong’s "face", the Lujiazui Financeand Trade Zone, is more striking. Hundredsof tall buildings have sprung up likemushrooms in Pudong; the grand YangpuBridge and Nanpu Bridge cross the HuangpuRiver, setting each other off fantasticallywith the imposing Oriental Pearl TV Towernearby; the broad avenue traverses the zonelike a rainbow; the new Shanghai CommerceCity is emerging on the horizon,
