光声成像作为一种兼具高光学对比度和大超声探测深度的新兴成像方法,突破了传统光学成像技术分辨率与成像深度相互制约的壁垒,获得了空前快速的发展,其中,光声显微成像技术继承了光声成像技术的优点,采用声学或光学聚焦的成像模式,可以...光声成像作为一种兼具高光学对比度和大超声探测深度的新兴成像方法,突破了传统光学成像技术分辨率与成像深度相互制约的壁垒,获得了空前快速的发展,其中,光声显微成像技术继承了光声成像技术的优点,采用声学或光学聚焦的成像模式,可以实现高对比度、高分辨率的生物组织结构、分子与功能成像,在神经学、眼科、血管生物学和皮肤学等研究领域具有潜在应用价值。为此,首先介绍了光声成像技术的原理和分类,然后围绕光声显微成像(Photoacoustic microscopy,PAM)技术这一主题,重点综述了新型PAM技术的发展情况、PAM焦深(Depth of focus,DoF)延拓技术以及PAM的生物医学应用。最后,总结了PAM技术发展存在的挑战,并对未来发展方向进行了展望。展开更多
The incidence and mortality of cardiovascular diseases and gastrointestinal cancer have gradually increased in recent years,and these diseases have become major social and public-health concerns.New requirements have ...The incidence and mortality of cardiovascular diseases and gastrointestinal cancer have gradually increased in recent years,and these diseases have become major social and public-health concerns.New requirements have been proposed for the clinical diagnosis of these diseases in the hope that,by accessing accurate structural information,to further grasp the functional information which closely related to the development of the diseases.Photoacoustic imaging is a new imaging method in which ultrasonic signals are generated from biological samples by laser-pulse irradiation.It has the advantages of high optical contrast,large ultrasound penetration depth,and high resolution.Additionally,it can acquire spectral information.The integration of a photoacoustic imaging system into a tiny imaging catheter can realize interventional imaging based on photoacoustic principles.The combination of structural imaging of cardiovascular and gastrointestinal lesion regions with photoacoustic spectroscopy to identify and quantify tissue components can realize highly sensitive functional imaging.After surveying the recent progress in the development of the photoacoustic imaging method for interventional application,with a particular emphasis on intravascular photoacoustic imaging,photoacoustic endoscopy,and photoacoustic spectroscopy,we summarize and identify future research directions for interventional photoacoustic imaging.展开更多
文摘光声成像作为一种兼具高光学对比度和大超声探测深度的新兴成像方法,突破了传统光学成像技术分辨率与成像深度相互制约的壁垒,获得了空前快速的发展,其中,光声显微成像技术继承了光声成像技术的优点,采用声学或光学聚焦的成像模式,可以实现高对比度、高分辨率的生物组织结构、分子与功能成像,在神经学、眼科、血管生物学和皮肤学等研究领域具有潜在应用价值。为此,首先介绍了光声成像技术的原理和分类,然后围绕光声显微成像(Photoacoustic microscopy,PAM)技术这一主题,重点综述了新型PAM技术的发展情况、PAM焦深(Depth of focus,DoF)延拓技术以及PAM的生物医学应用。最后,总结了PAM技术发展存在的挑战,并对未来发展方向进行了展望。
基金supported in part by the National Natural Science Foundation of China(No.61475182)the Scientific Research Project of Guangzhou University (No. ZJH3-2001)+2 种基金the Research Projects in Colleges and Universities of Guangzhou(No.1201610315)the Shenzhen Science and Technology Innovation Grant(Nos.JCYJ2015073 1154850923,JCYJ20160608214524052)the Science and Technology Department of Xuzhou city(No.KC16SY 158)
文摘The incidence and mortality of cardiovascular diseases and gastrointestinal cancer have gradually increased in recent years,and these diseases have become major social and public-health concerns.New requirements have been proposed for the clinical diagnosis of these diseases in the hope that,by accessing accurate structural information,to further grasp the functional information which closely related to the development of the diseases.Photoacoustic imaging is a new imaging method in which ultrasonic signals are generated from biological samples by laser-pulse irradiation.It has the advantages of high optical contrast,large ultrasound penetration depth,and high resolution.Additionally,it can acquire spectral information.The integration of a photoacoustic imaging system into a tiny imaging catheter can realize interventional imaging based on photoacoustic principles.The combination of structural imaging of cardiovascular and gastrointestinal lesion regions with photoacoustic spectroscopy to identify and quantify tissue components can realize highly sensitive functional imaging.After surveying the recent progress in the development of the photoacoustic imaging method for interventional application,with a particular emphasis on intravascular photoacoustic imaging,photoacoustic endoscopy,and photoacoustic spectroscopy,we summarize and identify future research directions for interventional photoacoustic imaging.