基于ANSYS的四川岷江犍为航电枢纽工程泄水闸结构分析

根据四川岷江犍为航电枢纽工程的实际情况,采用ANSYS三维计算对电站泄水闸三个坝段的结构应力结构进行计算分析。结果认为,岷江犍为航电枢纽工程泄水闸中间典型坝段(3#~25#坝段)地震工况的位移相对一般工况较大;在一侧检修工况下,泄水闸坝轴向位移较大。从应力分布情况来看,泄水闸的设计是合适的。边坝段(1#坝段)在检修工况下,闸墩顶部有较大的位移,门槽部位、闸墩底部产生较大的应力集中,经配筋计算分析,结构布置比较合理。

过氧化物氧化还原酶蛋白1在乳腺癌组织中表达及对乳腺癌细胞生长调控机制的研究

目的探讨过氧化物氧化还原酶蛋白1(PRDX1)在乳腺癌组织中的表达及对乳腺癌细胞生长调控的机制。方法选择2017年4月至2019年2月在北大医疗鲁中医院进行手术治疗的86例乳腺癌患者为研究对象,分析PRDX1表达与乳腺癌患者临床病理特征的关系。培养MCF7乳腺癌细胞株,分组转染成空白对照组、siRNA-NC组、PRDX1-siRNA转染组。检测不同组细胞增殖抑制率及凋亡率,采用Western blot检测PI3K/AKT信号通路相关蛋白表达水平。结果①PRDX1在乳腺癌及癌旁组织中的阳性率为58.1%(50/86)、23.3%(20/86)、在正常组织中的阳性率为3.7%(3/82),PRDX1在乳腺癌癌组织中的阳性率较高,且PRDX1阳性表达与乳腺癌患者的TNM分期、病理分级有关(P<0.05)。②TT检测结果显示,在24 h、48 h、72 h时,siRNA-NC组的细胞抑制率分别为1.6%、1.7%、2.4%,PRDX1-siRNA组分别为5.6%、15.3%、38.4%,PRDX1-siRNA组的细胞抑制率高于空白组与siRNA-NC组(P<0.05)。③流式细胞检测显示,空白组、siRNA-NC组、PRDX1-siRNA组的凋亡率分别为(7.7±1.3)%、(7.4±1.5)%、(25.7±4.2)%,PRDX1-siRNA的肿瘤凋亡率最高。④Western blot检测显示,与空白组相比,siRNA-NC组的PI3K蛋白、AKT蛋白表达量无明显变化,但PRDX1-siRNA组中PI3K蛋白、AKT蛋白的表达量下降(P<0.05)。结论PRDX1在乳腺癌患者中的阳性率明显提高。在MCF7乳腺癌细胞株中,抑制PRDX1表达水平可通过降低PI3K/AKT信号通路活性,促进乳腺癌细胞凋亡。

Analysis of a Rainstorm Process Far from the Typhoon "Haitang"

Based on multiple kinds of observation data and NCEP/NCAR reanalysis data,the circulation background,cloud clusters and radar characteristics of a rainstorm far from the typhoon " Haitang" in Lianyungang,Jiangsu on the morning of July 31,2017 were analyzed,and causes of convection were discussed from the aspects of dynamic,thermal and water vapor conditions. The results showed that the rainstorm process was caused by convection cells with low center of mass,and strong convection mainly occurred in a position where temperature gradient at cloud top was the largest. In North China at 850 hP a,eastern cold air on the south side of anticyclonic circulation moved southwards and joined southeast air flow on the periphery of typhoon,which was the main reason for the occurrence of convection. The circulation of upper-level divergence and lowerlevel convergence was beneficial to the maintaining of convection. The convergence of southeast wind speed on the periphery of typhoon made water vapor accumulate,thereby providing enough water vapor for the appearance of heavy rainfall. K index had good denotative meaning to convection activity,and the process of convection with weak Cape value needs to be paid special attention to in business. The prediction effect of rainfall distribution and areas by the models EC and ECRC was superior to other models.

Early Warning Role of Data from Automatic Stations in Forecast of Dense Fog

Based on observation data from automatic stations in Lianyungang, visibility and weather situation of dense fog leading to a traffic accident in Lianyungang on April 15, 2012 were analyzed firstly, and then changes of meteorological factors related to fog appearance and disappearance, such as wind speed, temperature and relative humidity, were discussed. The results showed that wind speed was below 2 m/s when fog occurred, and wind velocity reduced obviously before visibility deceased, appearing a trough. Fog appeared when temperature was neady the minimum, and there was no great change in wind speed, but visibility went up gradually after temperature rose. The longer the duration of the minimum temperature, the longer the duration of the minimum visibility. Moreover, visibility would become low after temperature rose.

一种插接式增压器回油管的设计与应用

针对某柴油机增压器回油管整体难拆装、增压器回油口法兰内部固定M8螺栓无法按照标准力矩38 N·m拧紧的问题。通过多次拆装经验与总结分析,在现有空间紧促的基础上,新设计了一种插接式增压器回油管,并进行相关验证试验。试验结果表明:优化后的增压器回油管满足密封要求,有效地解决了布置空间紧促情况下增压器回油口法兰内部固定螺栓无法控制力矩以及增压器回油管整体难拆装的问题,提高了装机和维修效率。

妊娠期糖尿病孕妇孕前体质指数及孕期增长情况对新生儿出生体质量的影响

目的探讨妊娠期糖尿病孕妇孕前体质指数及孕期增长情况对新生儿出生体质量的影响。方法抽取2018年6月至2019年10月160例在潍坊市妇幼保健院接受完整治疗并分娩的孕妇,其中正常糖耐量(NGT)组和妊娠期糖尿病(GDM)组,每组80例,记录并比较两组年龄、分娩孕周、妊娠前体质指数(BMI)、分娩前BMI与新生儿出生体质量等。结果与NGT组比较,GDM组孕前BMI、孕期BMI增长、新生儿出生体质量均高于NGT组(P<0.05)。新生儿出生体质量与孕前BMI、孕期BMI增长呈正相关(P<0.05)。结论GDM孕妇孕前BMI过大、孕期BMI过快增长均会影响新生儿的出生体质量,导致巨大儿以及不良妊娠结局,对GDM孕妇进行孕前体质量和孕期BMI增长情况的监测和控制,进行必要的运动锻炼和饮食指导均有助于降低新生儿的出生体质量,避免巨大儿的发生。