OBJECTIVE: To address the optimal Chinese herbal injections(CHIs) against liver cancer, the present network Meta-analysis is designed to investigate the comparative efficacy and safety of different CHIs.METHODS: Sever...OBJECTIVE: To address the optimal Chinese herbal injections(CHIs) against liver cancer, the present network Meta-analysis is designed to investigate the comparative efficacy and safety of different CHIs.METHODS: Several electronic databases were searched up to June 1 st, 2017. The quality assessment was conducted and network Meta-analysis was performed to compare the efficacy and safety of different CHIs plus transcatheter hepatic arterial chemoembolization(TACE). Primary outcomes were 1-year and 2-year survival rate, the secondary outcomes includes the clinical effective rate, performance status and the adverse reactions(ADRs). Data analysis was applied Stata 13.0 and Win BUGS 1.4 software.RESULTS: A total of 105 randomized controlled trials(RCTs) were identified for inclusion in this analysis, with data for 7683 patients and 13 CHIs. The results suggested that Javanica oil emulsion,Huachansu injection plus TACE were more favorable for 1-year and 2-year survival rate than other CHIs. Kanglaite, Astragalus polysaccharide injection plus TACE showed superiority in the clinical effective rate and performance status over other CHIs.And Shenmai injection plus TACE was superior to reducing ADRs than other CHIs for patients with liver cancer.CONCLUSION: Our findings indicated that receiving CHIs combined with TACE may have therapeutic benefits for patients with liver cancer in improving survival rate, clinical effective rate, the performance status and alleviating the ADRs.展开更多
OBJECTIVE:to evaluate the effectiveness and safety of Huachansu(HCS)injection plus chemotherapy in the treatment of gastric cancer.METHODS:A thorough and systematic retrieval of randomized controlled trials(RCTs)conce...OBJECTIVE:to evaluate the effectiveness and safety of Huachansu(HCS)injection plus chemotherapy in the treatment of gastric cancer.METHODS:A thorough and systematic retrieval of randomized controlled trials(RCTs)concerning HCS injection for treating gastric cancer was conducted in several electronic databases from inception to May 10,2018.The quality of the RCTs was assessed by the Cochrane risk of bias tool.And the data about objective remission rate,performance status,adverse drug reactions(ADRs)and other outcomes were extracted and analyzed by Review Manager 5.3 and Stata 13.0 software.RESULTS:A total of 14 RCTs with 976 participants were involved in the current Meta-analysis.The results suggested that HCS injection combined with chemotherapy was associated with better effects than receiving conventional chemotherapy alone in respect of improving the objective response rate[RR=1.18,95%CI(1.03,1.37),Z=2.32,P=0.02],and performance status[RR=1.84,95%CI(1.43,2.36),Z=4.74,P<0.00001].In addition,HCS injection combined with chemotherapy could relieve pain for patients with gastric cancer.CONCLUSION:This Meta-analysis revealed that HCS injection plus chemotherapy might more effective than chemotherapy in treating gastric cancer.Nevertheless,more large-scale and rigorously designed RCTs should be performed to validate this finding.展开更多
基金Supported by the National Natural Science Foundation of China(Study on the Key Influential Factors of Anaphylaxis Induced by Chinese Herbal Injection Based on Three-dimensional Database and Multi-dimensional Data Mining,No.81473547Establishment of Multi-dimensional Clinical Evaluation Model of Danshen Injection for Treating Unstable Angina Pectoris Based on Bayesian Network Meta Analysis,No.81673829)。
文摘OBJECTIVE: To address the optimal Chinese herbal injections(CHIs) against liver cancer, the present network Meta-analysis is designed to investigate the comparative efficacy and safety of different CHIs.METHODS: Several electronic databases were searched up to June 1 st, 2017. The quality assessment was conducted and network Meta-analysis was performed to compare the efficacy and safety of different CHIs plus transcatheter hepatic arterial chemoembolization(TACE). Primary outcomes were 1-year and 2-year survival rate, the secondary outcomes includes the clinical effective rate, performance status and the adverse reactions(ADRs). Data analysis was applied Stata 13.0 and Win BUGS 1.4 software.RESULTS: A total of 105 randomized controlled trials(RCTs) were identified for inclusion in this analysis, with data for 7683 patients and 13 CHIs. The results suggested that Javanica oil emulsion,Huachansu injection plus TACE were more favorable for 1-year and 2-year survival rate than other CHIs. Kanglaite, Astragalus polysaccharide injection plus TACE showed superiority in the clinical effective rate and performance status over other CHIs.And Shenmai injection plus TACE was superior to reducing ADRs than other CHIs for patients with liver cancer.CONCLUSION: Our findings indicated that receiving CHIs combined with TACE may have therapeutic benefits for patients with liver cancer in improving survival rate, clinical effective rate, the performance status and alleviating the ADRs.
基金Supported by the National Natural Science Foundation of China Study on Key Influencing Factors of Allergic Reaction Induced by Chinese Herbal Injection Based on Three-Dimensional Database and Multidimensional Data Mining(No.81473547)Construction of Multi-Dimensional Clinical Evaluation Model of Salvia Miltiorrhiza Injection in the Treatment of Unstable Angina Pectoris Based on Bayesian Network Meta-Analysis(No.81673829)Young Scientists Training Program of Beijing University of Chinese Medicine
文摘OBJECTIVE:to evaluate the effectiveness and safety of Huachansu(HCS)injection plus chemotherapy in the treatment of gastric cancer.METHODS:A thorough and systematic retrieval of randomized controlled trials(RCTs)concerning HCS injection for treating gastric cancer was conducted in several electronic databases from inception to May 10,2018.The quality of the RCTs was assessed by the Cochrane risk of bias tool.And the data about objective remission rate,performance status,adverse drug reactions(ADRs)and other outcomes were extracted and analyzed by Review Manager 5.3 and Stata 13.0 software.RESULTS:A total of 14 RCTs with 976 participants were involved in the current Meta-analysis.The results suggested that HCS injection combined with chemotherapy was associated with better effects than receiving conventional chemotherapy alone in respect of improving the objective response rate[RR=1.18,95%CI(1.03,1.37),Z=2.32,P=0.02],and performance status[RR=1.84,95%CI(1.43,2.36),Z=4.74,P<0.00001].In addition,HCS injection combined with chemotherapy could relieve pain for patients with gastric cancer.CONCLUSION:This Meta-analysis revealed that HCS injection plus chemotherapy might more effective than chemotherapy in treating gastric cancer.Nevertheless,more large-scale and rigorously designed RCTs should be performed to validate this finding.
