目的:探讨己酮可可碱对非痴呆型血管性认知功能障碍患者认知功能障碍的改善作用。方法:选取2019年6月至2020年8月于河北省第八人民医院住院治疗的非痴呆型血管性认知功能障碍患者55例,根据随机数字表法分为对照组(n=27)和观察组(n=28)...目的:探讨己酮可可碱对非痴呆型血管性认知功能障碍患者认知功能障碍的改善作用。方法:选取2019年6月至2020年8月于河北省第八人民医院住院治疗的非痴呆型血管性认知功能障碍患者55例,根据随机数字表法分为对照组(n=27)和观察组(n=28)。对照组患者给予常规治疗,观察组患者在常规治疗的基础上加用己酮可可碱缓释片治疗。观察两组患者的局部脑血流、神经功能缺损程度评分(neural function defect score,NFDS)、日常生活活动(activity of daily living,ADL)评分和认知功能[简易精神状态检查量表(mini mental status examination,MMSE)、蒙特利尔认知评测量表(Montreal cognitive assessment,MoCA)]评分,并进行药物的安全性评价。结果:与对照组比较,观察组患者治疗1、3和6个月的各脑区血流量显著升高,NFDS评分显著降低,ADL、MMSE和MoCA评分显著升高,上述差异均有统计学意义(P <0.05)。观察组、对照组患者的不良反应发生率分别为3.57%(1/28)、7.41%(2/27),差异无统计学意义(χ^(2)=0.001,P=0.974)。结论:己酮可可碱可显著改善非痴呆型血管性认知功能障碍患者的临床症状,提高脑血管的血流量,降低NFDS评分,提高ADL、MMSE和MoCA评分,临床疗效显著,且安全性高。展开更多
The public information signs( The term public information signs will be abbreviated to public signs in the following text.)in the urban areas not only offer convenience for people to move around, but also reflect the ...The public information signs( The term public information signs will be abbreviated to public signs in the following text.)in the urban areas not only offer convenience for people to move around, but also reflect the level of development and progress of those areas. It is essential to the creative development and uplifting of the New Costal Area (thereafter, NCA) to have a good understanding of its present situation with regard to its public signs, to discuss the related issues in the development, to work out a system that is up to international standard and develop its own standards in the course of implementing the national strategies on standardizing public signs.展开更多
文摘目的:探讨己酮可可碱对非痴呆型血管性认知功能障碍患者认知功能障碍的改善作用。方法:选取2019年6月至2020年8月于河北省第八人民医院住院治疗的非痴呆型血管性认知功能障碍患者55例,根据随机数字表法分为对照组(n=27)和观察组(n=28)。对照组患者给予常规治疗,观察组患者在常规治疗的基础上加用己酮可可碱缓释片治疗。观察两组患者的局部脑血流、神经功能缺损程度评分(neural function defect score,NFDS)、日常生活活动(activity of daily living,ADL)评分和认知功能[简易精神状态检查量表(mini mental status examination,MMSE)、蒙特利尔认知评测量表(Montreal cognitive assessment,MoCA)]评分,并进行药物的安全性评价。结果:与对照组比较,观察组患者治疗1、3和6个月的各脑区血流量显著升高,NFDS评分显著降低,ADL、MMSE和MoCA评分显著升高,上述差异均有统计学意义(P <0.05)。观察组、对照组患者的不良反应发生率分别为3.57%(1/28)、7.41%(2/27),差异无统计学意义(χ^(2)=0.001,P=0.974)。结论:己酮可可碱可显著改善非痴呆型血管性认知功能障碍患者的临床症状,提高脑血管的血流量,降低NFDS评分,提高ADL、MMSE和MoCA评分,临床疗效显著,且安全性高。
文摘The public information signs( The term public information signs will be abbreviated to public signs in the following text.)in the urban areas not only offer convenience for people to move around, but also reflect the level of development and progress of those areas. It is essential to the creative development and uplifting of the New Costal Area (thereafter, NCA) to have a good understanding of its present situation with regard to its public signs, to discuss the related issues in the development, to work out a system that is up to international standard and develop its own standards in the course of implementing the national strategies on standardizing public signs.
