The epic show Great Journey,celebrating The 100th Anniversary of the Founding of The Communist Party of China(CPC),presents CPC's glorious journey over the past century.It energized and inspired Chinese people,win...The epic show Great Journey,celebrating The 100th Anniversary of the Founding of The Communist Party of China(CPC),presents CPC's glorious journey over the past century.It energized and inspired Chinese people,winning widespread acclaims and evoking resonance among all walks of life.展开更多
Eight novel clerodane diterpenoids(1-8)were isolated from the twigs of Casearia graveolens.Their structures were elucidated through comprehensive nuclear magnetic resonance(NMR),high-resolution electrospray ionization...Eight novel clerodane diterpenoids(1-8)were isolated from the twigs of Casearia graveolens.Their structures were elucidated through comprehensive nuclear magnetic resonance(NMR),high-resolution electrospray ionization mass spectrometry(HRESI-MS),and electronic circular dichroism(ECD)analyses.In addition to structural determination,surface plasmon resonance(SPR)assays were conducted to investigate molecular interactions,revealing that compound 8 exhibited high affinity for vascular endothelial growth factor receptor 2(VEGFR2),a key regulator of tumor angiogenesis.Subsequent in vivo experiments demonstrated that compound 8 effectively inhibited angiogenesis and displayed significant antitumor activity by suppressing tumor proliferation and metastasis in zebrafish xenograft models.These findings suggest that compound 8 holds promise as an anticancer lead compound targeting VEGFR-2 to obstruct tumor angiogenesis.展开更多
文摘The epic show Great Journey,celebrating The 100th Anniversary of the Founding of The Communist Party of China(CPC),presents CPC's glorious journey over the past century.It energized and inspired Chinese people,winning widespread acclaims and evoking resonance among all walks of life.
基金supported by the National Natural Science Foundation of China(No.22077067)the Project of State Key Laboratory of Functions and Applications of Medicinal Plants,Guizhou Medical University[No.QJJ(2022)422]the 111 Project(No.B20016)。
文摘Eight novel clerodane diterpenoids(1-8)were isolated from the twigs of Casearia graveolens.Their structures were elucidated through comprehensive nuclear magnetic resonance(NMR),high-resolution electrospray ionization mass spectrometry(HRESI-MS),and electronic circular dichroism(ECD)analyses.In addition to structural determination,surface plasmon resonance(SPR)assays were conducted to investigate molecular interactions,revealing that compound 8 exhibited high affinity for vascular endothelial growth factor receptor 2(VEGFR2),a key regulator of tumor angiogenesis.Subsequent in vivo experiments demonstrated that compound 8 effectively inhibited angiogenesis and displayed significant antitumor activity by suppressing tumor proliferation and metastasis in zebrafish xenograft models.These findings suggest that compound 8 holds promise as an anticancer lead compound targeting VEGFR-2 to obstruct tumor angiogenesis.
