Cu,Zn SOD is a highly conserved enzyme and the controversy about its evolutionary possibility in the near future has been lively. In order to further our understanding of the future fate of human Cu,Zn SOD, we adopt...Cu,Zn SOD is a highly conserved enzyme and the controversy about its evolutionary possibility in the near future has been lively. In order to further our understanding of the future fate of human Cu,Zn SOD, we adopted a strategy relating to the directed evolution to study how the mutants of human Cu,Zn SOD respond to different oxidative stress. After five rounds of screening, we found a mutant that can survive under harsh pressures and DNA sequencing proves that it shows a mutation responsible for the phenomenon. However, under natural pressure, our screening comes to nothing. Then we may draw the following conclusions: the evolution of biological macromolecules in some respect depends on their surroundings and if they are too familiar with a certain environment, they may embody evolutionary inertia.展开更多
Due to an increasing life expectancy and decreasing fertility rate,China officially entered a stage of increased ageing in 2011[1].According to China’s seventh national census,2019,the country’s overall population w...Due to an increasing life expectancy and decreasing fertility rate,China officially entered a stage of increased ageing in 2011[1].According to China’s seventh national census,2019,the country’s overall population was 1.44 billion,and this included eighteen per cent of people over 60(13.5%of people exceeding 65 years old).展开更多
On October 17, 1997, the correspondents fromthe China Tendering Weekly interviewed Mr. PrebenJensen, Procurement Adviser from the World Bankand Mr Luiz Gazoni, Sr. Operation Officer from theWorld Bank Resident Mission...On October 17, 1997, the correspondents fromthe China Tendering Weekly interviewed Mr. PrebenJensen, Procurement Adviser from the World Bankand Mr Luiz Gazoni, Sr. Operation Officer from theWorld Bank Resident Mission in China who came toXi’ an to attend the Senior Seminar on Procurement,sponsored by the Ministry of Finance.Firstly, the correspondent gave a brief introduction of the China Tendering to Mr. Jensen andMr. Gazoni as follows:The Weekly magazine was founded in 1992 withthe principle of popularizing the theories and experiences on tendering, and issuing bid notices domestically and internationally. In the past few years, theChina Fardering has not only published the noticesfor the projects financed by the World Bank in China, but also made public information on tenderingand procurement of various domestic projects. "Lastyear, Mr. Fringer from the World Bank headquarterspaid a visit to the China Tendering Weekly, and展开更多
文摘Cu,Zn SOD is a highly conserved enzyme and the controversy about its evolutionary possibility in the near future has been lively. In order to further our understanding of the future fate of human Cu,Zn SOD, we adopted a strategy relating to the directed evolution to study how the mutants of human Cu,Zn SOD respond to different oxidative stress. After five rounds of screening, we found a mutant that can survive under harsh pressures and DNA sequencing proves that it shows a mutation responsible for the phenomenon. However, under natural pressure, our screening comes to nothing. Then we may draw the following conclusions: the evolution of biological macromolecules in some respect depends on their surroundings and if they are too familiar with a certain environment, they may embody evolutionary inertia.
基金support by Chengdu Green and Low-carbon Development Research Base[No.LD23YB05]
文摘Due to an increasing life expectancy and decreasing fertility rate,China officially entered a stage of increased ageing in 2011[1].According to China’s seventh national census,2019,the country’s overall population was 1.44 billion,and this included eighteen per cent of people over 60(13.5%of people exceeding 65 years old).
文摘On October 17, 1997, the correspondents fromthe China Tendering Weekly interviewed Mr. PrebenJensen, Procurement Adviser from the World Bankand Mr Luiz Gazoni, Sr. Operation Officer from theWorld Bank Resident Mission in China who came toXi’ an to attend the Senior Seminar on Procurement,sponsored by the Ministry of Finance.Firstly, the correspondent gave a brief introduction of the China Tendering to Mr. Jensen andMr. Gazoni as follows:The Weekly magazine was founded in 1992 withthe principle of popularizing the theories and experiences on tendering, and issuing bid notices domestically and internationally. In the past few years, theChina Fardering has not only published the noticesfor the projects financed by the World Bank in China, but also made public information on tenderingand procurement of various domestic projects. "Lastyear, Mr. Fringer from the World Bank headquarterspaid a visit to the China Tendering Weekly, and
