Transient global ischemia usually results in delayed neuronal death in selective brain regions,prior to which a rapid loss of dendritic spines has been widely reported in these regions.Dendritic spines are characteriz...Transient global ischemia usually results in delayed neuronal death in selective brain regions,prior to which a rapid loss of dendritic spines has been widely reported in these regions.Dendritic spines are characterized by a highly branched meshwork of actin cytoskeleton(F-actin),which is extremely vulnerable to the ATP-depleted conditions such as hypoxia/ischemia.However,the ischemia-induced changes of F-actin are still not clarified in the vulnerable brain areas.This study was designed to examine the temporal and spatial alterations of F-actin in the CA1 subfield of rat hippocampus following reperfusion after global cerebral ischemia.展开更多
文摘Transient global ischemia usually results in delayed neuronal death in selective brain regions,prior to which a rapid loss of dendritic spines has been widely reported in these regions.Dendritic spines are characterized by a highly branched meshwork of actin cytoskeleton(F-actin),which is extremely vulnerable to the ATP-depleted conditions such as hypoxia/ischemia.However,the ischemia-induced changes of F-actin are still not clarified in the vulnerable brain areas.This study was designed to examine the temporal and spatial alterations of F-actin in the CA1 subfield of rat hippocampus following reperfusion after global cerebral ischemia.