Objective:To investigate the mechanism of Fuyang Jiebiao granule(FYJBKL)in the treatment of viral pneumonia.Methods:Firstly,a network model was constructed using network pharmacology to study the target expression sit...Objective:To investigate the mechanism of Fuyang Jiebiao granule(FYJBKL)in the treatment of viral pneumonia.Methods:Firstly,a network model was constructed using network pharmacology to study the target expression sites of FYJBKL viral pneumonia,so as to determine the main targets and important signal transduction pathways for the treatment of viral pneumonia.Secondly,the main components of the drug and the main target are docked.Then,the fever,sweating and inflammation rat models were established to explore the antipyretic,sweating and anti-inflammatory mechanisms of FYJBKL.Finally,the contents of IL-17,IL-1β,TNF-αand IL-6 in blood samples of rats were analyzed by ELISA method,and the morphological changes of lung tissue were observed by HE staining.Results:Quercetin,luteolin,kaempferol,etc.,and the main mechanism targets are IL-17,IL-1β,TNF-α,IL-6 and so on.Thirty signal pathways were identified by KEGG enrichment analysis,including interleukin-17 signaling pathway(IL-17 signaling pathway),human cytomegalovirus infection pathway(human cytomegalovirus infection),Kaposi's sarcoma associated herpesvirus infection pathway(Kaposi's sarcoma-as-sociated herpesvirus infection)and so on.After the study of molecular docking,we found that the contact efficiency between active substances and possible key targets is good.The high and middle concentration groups of FYJBKL significantly decreased the expression of IL-17,IL-1β,TNF-αand IL-6 in the blood of rats with inflammation(P<0.05).FYJBKL significantly reduced the foot swelling induced by egg white and inhibited the increase of body temperature induced by yeast in rats(P<0.05).HE staining showed that FYJBKL improved pulmonary fibrosis and inflammatory exudation to varying degrees.Conclusion:The effects of FuyangJiebiao granules on the related signal pathways of anti-virus,anti-immune and anti-inflammation as well as biological and cellular processes may be caused by the binding of quercetin,luteolin,kaempferol and other active ingredients to their shared targets.Fuyang Jiebiao granules can improve the related symptoms caused by viral pneumonia,and its mechanism may be related to the activities of TNF,IL-17,IL-6 and other related channels,which are multiple targets of inflammation regulation.展开更多
针对新能源接入后的无功电压控制问题,基于模型预测控制(model predictive control,MPC)理论,提出一种多阶段自动电压控制(automatic voltage control,AVC)优化策略。在日前优化安排离散无功补偿设备(电容器、有载变压器分接头)投切计...针对新能源接入后的无功电压控制问题,基于模型预测控制(model predictive control,MPC)理论,提出一种多阶段自动电压控制(automatic voltage control,AVC)优化策略。在日前优化安排离散无功补偿设备(电容器、有载变压器分接头)投切计划的基础上,日内采用基于MPC的优化控制思路,利用连续无功补偿装置(static var generator,SVG)对电压进行控制。通过建立灵敏度矩阵计算得到未来多个时刻的母线电压预测值;以最小化未来一段时间预测的电压控制偏差为目标函数,建立日内滚动优化控制模型,求解得到SVG的出力序列,并通过反馈校正,完成日内无功电压MPC。在改进的IEEE 30算例的基础上对所提方法进行验证,结果表明,该方法能够有效应对电网电压快速频繁波动的问题,及时追踪电网电压波动,使SVG出力更加平滑、电压控制效果更好。展开更多
目的:探讨针灸联合银杏达莫治疗炮震性耳鸣类军事训练伤的临床效果。方法:选取2015年8月至2016年7月军事训练后产生的84例因炮震训练引起单侧耳鸣的84例患者作为研究对象,将患者按数字分组法随机平均分为2组,对照组42例采用银杏达莫注射...目的:探讨针灸联合银杏达莫治疗炮震性耳鸣类军事训练伤的临床效果。方法:选取2015年8月至2016年7月军事训练后产生的84例因炮震训练引起单侧耳鸣的84例患者作为研究对象,将患者按数字分组法随机平均分为2组,对照组42例采用银杏达莫注射液20 m L加入5%葡萄糖溶液250 m L中静脉滴注进行治疗,观察组在此基础上辅以针灸治疗,比较2组患者的治疗效果、症状改善情况、不良反应。结果:治疗2个疗程后,观察组患者痊愈20例,线型10例,有效9例,无效3例,治疗有效率为92.85%;对照组患者痊愈15例,显效5例,有效10例,无效12例,治疗有效率为71.42%;观察组治疗有效率明显高于对照组,差异统计学意义(P<0.05)。2组在治疗前耳鸣评分及听力差异无统计学意义(P>0.05);观察组治疗后耳鸣评分(4.02±2.28)分、听力(30.76±2.53)d B,同期对照组治疗后耳鸣评分(7.98±2.43)分、听力(35.84±2.86)d B,观察组耳鸣症状及听力明显较对照组好转,差异有统计学意义(P<0.05)。2组在治疗过程中均出现了不同程度的不良反应,观察组恶心呕吐、皮疹、头晕等不良反应发生率为28.58%与对照组的23.80%比较,差异无统计学意义(P>0.05)。结论:针灸联合银杏达莫治疗炮震性耳鸣类军事训练伤的临床效果显著,能有效改善耳部血液循环,辅助中医针灸治疗可疏通经气、活血化瘀,有利于本病的根治,提升整体治疗的优势,且安全性高,不良反应可控,具有积极的临床意义。展开更多
目的观察阴道部分封闭术治疗重度盆底器官脱垂的疗效。方法选取2016年1月-2017年1月于本院接受治疗的重度盆底器官脱垂患者56例,根据手术方式将患者分为阴道封闭组(n=20)及传统手术组(n=36),观察阴道部分封闭术治疗重度盆底器官脱垂的...目的观察阴道部分封闭术治疗重度盆底器官脱垂的疗效。方法选取2016年1月-2017年1月于本院接受治疗的重度盆底器官脱垂患者56例,根据手术方式将患者分为阴道封闭组(n=20)及传统手术组(n=36),观察阴道部分封闭术治疗重度盆底器官脱垂的疗效。结果阴道封闭组术中出血量[(204.65±20.36) ml vs (294.65±30.29)] ml、手术时间[(1.21±0.25) h vs (1.76±0.14) h]、术后下床时间[(1.52±0.58) d vs (2.01±0.64) d]、住院时间[(7.25±1.36) d vs (9.25±1.24) d]均显著低于传统手术组(P均<0.05)。两组手术前PFDI-20及PFIQ-7评分均无统计学差异(P> 0.05);术后随访1年,两组评分均较前明显改善,且阴道封闭组优于传统手术组(4.25±1.02 vs 7.25±1.59,P=0.000;44.92±19.36 vs57.25±18.25,P=0.038)。阴道封闭组治疗总有效率高达95.00%,传统手术组总有效率仅为69.44%,差异有统计学意义(P=0.000)。结论相比传统手术,阴道部分封闭术治疗重度盆底器官脱垂效果显著,值得临床推广使用。展开更多
基金Emergency Research Project for Novel Coronavirus(2019-nCoV)Prevention and Control in Shanxi Province(No.202003D31012/GZ)Jingfang Fuyang Key Laboratory of Shanxi Province(No.202104010910011)Shanxi Provincial Health Commission Key Laboratory Construction Project。
文摘Objective:To investigate the mechanism of Fuyang Jiebiao granule(FYJBKL)in the treatment of viral pneumonia.Methods:Firstly,a network model was constructed using network pharmacology to study the target expression sites of FYJBKL viral pneumonia,so as to determine the main targets and important signal transduction pathways for the treatment of viral pneumonia.Secondly,the main components of the drug and the main target are docked.Then,the fever,sweating and inflammation rat models were established to explore the antipyretic,sweating and anti-inflammatory mechanisms of FYJBKL.Finally,the contents of IL-17,IL-1β,TNF-αand IL-6 in blood samples of rats were analyzed by ELISA method,and the morphological changes of lung tissue were observed by HE staining.Results:Quercetin,luteolin,kaempferol,etc.,and the main mechanism targets are IL-17,IL-1β,TNF-α,IL-6 and so on.Thirty signal pathways were identified by KEGG enrichment analysis,including interleukin-17 signaling pathway(IL-17 signaling pathway),human cytomegalovirus infection pathway(human cytomegalovirus infection),Kaposi's sarcoma associated herpesvirus infection pathway(Kaposi's sarcoma-as-sociated herpesvirus infection)and so on.After the study of molecular docking,we found that the contact efficiency between active substances and possible key targets is good.The high and middle concentration groups of FYJBKL significantly decreased the expression of IL-17,IL-1β,TNF-αand IL-6 in the blood of rats with inflammation(P<0.05).FYJBKL significantly reduced the foot swelling induced by egg white and inhibited the increase of body temperature induced by yeast in rats(P<0.05).HE staining showed that FYJBKL improved pulmonary fibrosis and inflammatory exudation to varying degrees.Conclusion:The effects of FuyangJiebiao granules on the related signal pathways of anti-virus,anti-immune and anti-inflammation as well as biological and cellular processes may be caused by the binding of quercetin,luteolin,kaempferol and other active ingredients to their shared targets.Fuyang Jiebiao granules can improve the related symptoms caused by viral pneumonia,and its mechanism may be related to the activities of TNF,IL-17,IL-6 and other related channels,which are multiple targets of inflammation regulation.
文摘针对新能源接入后的无功电压控制问题,基于模型预测控制(model predictive control,MPC)理论,提出一种多阶段自动电压控制(automatic voltage control,AVC)优化策略。在日前优化安排离散无功补偿设备(电容器、有载变压器分接头)投切计划的基础上,日内采用基于MPC的优化控制思路,利用连续无功补偿装置(static var generator,SVG)对电压进行控制。通过建立灵敏度矩阵计算得到未来多个时刻的母线电压预测值;以最小化未来一段时间预测的电压控制偏差为目标函数,建立日内滚动优化控制模型,求解得到SVG的出力序列,并通过反馈校正,完成日内无功电压MPC。在改进的IEEE 30算例的基础上对所提方法进行验证,结果表明,该方法能够有效应对电网电压快速频繁波动的问题,及时追踪电网电压波动,使SVG出力更加平滑、电压控制效果更好。
文摘目的:探讨针灸联合银杏达莫治疗炮震性耳鸣类军事训练伤的临床效果。方法:选取2015年8月至2016年7月军事训练后产生的84例因炮震训练引起单侧耳鸣的84例患者作为研究对象,将患者按数字分组法随机平均分为2组,对照组42例采用银杏达莫注射液20 m L加入5%葡萄糖溶液250 m L中静脉滴注进行治疗,观察组在此基础上辅以针灸治疗,比较2组患者的治疗效果、症状改善情况、不良反应。结果:治疗2个疗程后,观察组患者痊愈20例,线型10例,有效9例,无效3例,治疗有效率为92.85%;对照组患者痊愈15例,显效5例,有效10例,无效12例,治疗有效率为71.42%;观察组治疗有效率明显高于对照组,差异统计学意义(P<0.05)。2组在治疗前耳鸣评分及听力差异无统计学意义(P>0.05);观察组治疗后耳鸣评分(4.02±2.28)分、听力(30.76±2.53)d B,同期对照组治疗后耳鸣评分(7.98±2.43)分、听力(35.84±2.86)d B,观察组耳鸣症状及听力明显较对照组好转,差异有统计学意义(P<0.05)。2组在治疗过程中均出现了不同程度的不良反应,观察组恶心呕吐、皮疹、头晕等不良反应发生率为28.58%与对照组的23.80%比较,差异无统计学意义(P>0.05)。结论:针灸联合银杏达莫治疗炮震性耳鸣类军事训练伤的临床效果显著,能有效改善耳部血液循环,辅助中医针灸治疗可疏通经气、活血化瘀,有利于本病的根治,提升整体治疗的优势,且安全性高,不良反应可控,具有积极的临床意义。
文摘目的观察阴道部分封闭术治疗重度盆底器官脱垂的疗效。方法选取2016年1月-2017年1月于本院接受治疗的重度盆底器官脱垂患者56例,根据手术方式将患者分为阴道封闭组(n=20)及传统手术组(n=36),观察阴道部分封闭术治疗重度盆底器官脱垂的疗效。结果阴道封闭组术中出血量[(204.65±20.36) ml vs (294.65±30.29)] ml、手术时间[(1.21±0.25) h vs (1.76±0.14) h]、术后下床时间[(1.52±0.58) d vs (2.01±0.64) d]、住院时间[(7.25±1.36) d vs (9.25±1.24) d]均显著低于传统手术组(P均<0.05)。两组手术前PFDI-20及PFIQ-7评分均无统计学差异(P> 0.05);术后随访1年,两组评分均较前明显改善,且阴道封闭组优于传统手术组(4.25±1.02 vs 7.25±1.59,P=0.000;44.92±19.36 vs57.25±18.25,P=0.038)。阴道封闭组治疗总有效率高达95.00%,传统手术组总有效率仅为69.44%,差异有统计学意义(P=0.000)。结论相比传统手术,阴道部分封闭术治疗重度盆底器官脱垂效果显著,值得临床推广使用。
