Dear Editor, Influenza A virus （IAV） is an enveloped negative-strand RNA virus containing eight RNA segments that belongs to the family Orthomyxoviridae and can cause acute respiratory infection in humans and animal...Dear Editor, Influenza A virus （IAV） is an enveloped negative-strand RNA virus containing eight RNA segments that belongs to the family Orthomyxoviridae and can cause acute respiratory infection in humans and animals. Although vaccination is one of the major means for prophylaxis of influenza virus infection, a particular influenza vaccine only confers pro- tection for no more than a few years. In addition, the out- break of novel influenza infection cannot be predicted （Gao et al., 2013）. Thus, vaccine is unable to provide immediate protection against sudden influenza outbreaks with unknown identity. Development of antiviral drugs for therapeutic treatment is an important strategy to reduce the duration and severity of influenza. However,展开更多
文摘Dear Editor, Influenza A virus （IAV） is an enveloped negative-strand RNA virus containing eight RNA segments that belongs to the family Orthomyxoviridae and can cause acute respiratory infection in humans and animals. Although vaccination is one of the major means for prophylaxis of influenza virus infection, a particular influenza vaccine only confers pro- tection for no more than a few years. In addition, the out- break of novel influenza infection cannot be predicted （Gao et al., 2013）. Thus, vaccine is unable to provide immediate protection against sudden influenza outbreaks with unknown identity. Development of antiviral drugs for therapeutic treatment is an important strategy to reduce the duration and severity of influenza. However,
