For the first time, synthetic dipeptides were applied to the catalysis of asymmetric Reformatsky reaction. Review in this domain & factors influencing enantioselectivity were discussed.
The laser photolysis of N-diisopropyl phosphoryl tryptophyl tyrosine dipeptide methyl ester (N-DiPP-TrpH-TyrOH) has been carried out utilizing a KrF(248 nm) laser . The direct intramolecular ET between TrpH+ residue a...The laser photolysis of N-diisopropyl phosphoryl tryptophyl tyrosine dipeptide methyl ester (N-DiPP-TrpH-TyrOH) has been carried out utilizing a KrF(248 nm) laser . The direct intramolecular ET between TrpH+ residue and TyrOH residue was detected first and the ET between Trp and TyrOH became slow. It was suggested that phosphoryl group stabilize neighbour radical of aromatic ring by hyperconjugation. In combination with computer modeling we obtained the kinetic parameters of the ET and proved that phosphoryl groups took part in the process of ET. The results should be significant for biological system since every biological process involves the phosphorylation or nonphosphorylation.展开更多
文摘For the first time, synthetic dipeptides were applied to the catalysis of asymmetric Reformatsky reaction. Review in this domain & factors influencing enantioselectivity were discussed.
文摘The laser photolysis of N-diisopropyl phosphoryl tryptophyl tyrosine dipeptide methyl ester (N-DiPP-TrpH-TyrOH) has been carried out utilizing a KrF(248 nm) laser . The direct intramolecular ET between TrpH+ residue and TyrOH residue was detected first and the ET between Trp and TyrOH became slow. It was suggested that phosphoryl group stabilize neighbour radical of aromatic ring by hyperconjugation. In combination with computer modeling we obtained the kinetic parameters of the ET and proved that phosphoryl groups took part in the process of ET. The results should be significant for biological system since every biological process involves the phosphorylation or nonphosphorylation.
