Cellular automata are the discrete dynamical systems of simple construction but with complex and varied behaviors.In this paper,the elementary cellular automaton of rule 22 is studied by the tools of formal language t...Cellular automata are the discrete dynamical systems of simple construction but with complex and varied behaviors.In this paper,the elementary cellular automaton of rule 22 is studied by the tools of formal language theory and symbolic dynamics.Its temporal evolution orbits are coarse grained into evolution sequences and the evolution languages are defined.It is proved that for every n ≥2 its width n evolution language is not regular.展开更多
AIM: To study the effect of ginsenoside Rgl and Rhl on the anti - tumor activity of dendritic cells (DC). METHODS: Effect of Rgl and Rhl on the production of IL- 12 p40 protein was detected by ELISA, and the IL- 12 p4...AIM: To study the effect of ginsenoside Rgl and Rhl on the anti - tumor activity of dendritic cells (DC). METHODS: Effect of Rgl and Rhl on the production of IL- 12 p40 protein was detected by ELISA, and the IL- 12 p40 mRNA level of DC was monitored by RT- PCR. Anti - tumor activity of DC- LPAK was detemnined by neutral red staining assay. RESULTS: The results of ELLSA showed that Rgl and Rhl significantly enhanced the production of IL- 12 p40 of DC. Rgl at 1 mg/L and Rhl at 100 mg/L upregulated the IL- 12 p40 mRNA level. Rgl and Rhl enhanced the anti - tumor ability of DC, induced lyrnphokine and PHA activated killer (DC-LPAK) on human papillate tumor cell line. Each dose of Rgl can obviously accelerate the eytotoxity to L929 at the E: T ratio of 5 : 1 (P<0.05,0.01 ), while only Rhl 10 mg/L enhanced the eytotoxity ability of DC- LPAK (P < 0.05). CONCLUSION: Rgl and Rhl enhanced the production of IL-12 p40. This effect may be mediated by the increase in the mRNA level. As a result, Rg1 and Rhl oromote the ability of DC to stimulate the cytotoxitie aetieity of DC - LPAK.展开更多
墙,依托于凿洞为穴、构木为巢的原始居所,体现了人类最初的空间划分意识;后于“凿户牖以为室,当其无,有室之用,故有之以为利,无之以为用”中展示了人对“无”之意义的领悟。至此,人,坠入“树立-优化-消解”“墙”的循环往复中。在墙的...墙,依托于凿洞为穴、构木为巢的原始居所,体现了人类最初的空间划分意识;后于“凿户牖以为室,当其无,有室之用,故有之以为利,无之以为用”中展示了人对“无”之意义的领悟。至此,人,坠入“树立-优化-消解”“墙”的循环往复中。在墙的意象内涵越来越丰富的背后,是人类对“墙”认知和解析的累积：关于“墙”本身,关于“墙”的场域,关于“墙”的隐喻。所以有柏林墙的建而又拆;所以有列侬墙的精神不倒;所以有Jackson对“off the wall”的歌咏。人对客观事物的改造往往托于“人”本身的视角,基于“人”的心理意象。人常说,一千个人心中有一千个哈姆雷特。换言之,意象经常是人改变客观事物并使其达至自己内心完美目标的心源。于是,我们想,见过、听说过各色各样的墙后,如果立足于心理意象重新再认知“墙”呢？这将会对“墙”的进化有什么样的意义呢？展开更多
The multiglycosides of Triptvrygium wilfordii (GTW) was a male antifertility agvnt recently explorvd in China. In order to isolate the active principle from the drug, a couple of institutions have carried out work on ...The multiglycosides of Triptvrygium wilfordii (GTW) was a male antifertility agvnt recently explorvd in China. In order to isolate the active principle from the drug, a couple of institutions have carried out work on phytochemical separation and展开更多
Background Lipid abnormalities are often complicated by renal dysfunction. 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) are the first-line choice for lowering cholesterol levels. The present ...Background Lipid abnormalities are often complicated by renal dysfunction. 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) are the first-line choice for lowering cholesterol levels. The present study was designed to investigate whether statins could prevent and invert the development of renal injury in cholesterol-fed rabbits and to find the possible mechanism of their effects by detecting gene and protein expression of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in the renal artery.Methods Twenty-four male New Zealand white rabbits were divided into three groups: (1) control group, regular granules chow; (2) HC-diet group, granules chow with 1% cholesterol and 5% lard oil; and (3) fluvastatin group, 1% cholesterol and 5% lard oil diet plus fluvastatin (10 mg·kg -1 ·d -1 ) . After 16 weeks, serum total cholesterol (TC), low-density lipoprotein(LDL) and creatinine (Cr) levels were measured. Renal hemodynamics and function, mainly including glomerular filtration rate (GFR) in vivo were quantified using 99m Tc-DTPA single photon emission computed tomograph ( 99m Tc-DTPA SPECT). The thickness of the renal artery intima was quantitated in HE-stained segments by histomorphometry. Gene expression of LOX-1 in the renal artery was examined by semi-quantitative RT-PCR and its protein expression was evaluated by immunohistochemistry.Results High cholesterol diet induced hypercholesterolemia (HC) complicated by renal dysfunction with increased levels of serum lipid and Cr, decreased GFR and delayed excretion and extensively thickened renal arterial intima in the HC-diet group. Rabbits in the control group showed a minimal LOX-1 expression (mRNA and protein) in the endothelium and neointima of the renal artery. Intimal proliferation of the renal artery in the HC-diet group was associated with a marked increase of LOX-1 expression (protein and mRNA). Treatment with fluvastatin improved renal function, attenuated intimal proliferation of the renal artery and markedly decreased the enhanced LOX-1 expression in the endothelium and neointima of the renal artery in rabbits. Conclusions Fuvastatin treatment could prevent the development of renal injury in patients with HC and early atherosclerosis (AS). This beneficial effect might be mediated by its pleiotropic effects including a decrease in total cholesterol exposure level and prevention of LOX-1 expression in atherosclerotic arteries.展开更多
基金National Natural Science Foundation of China (1 0 1 0 1 0 1 6) Tian Yuan Founda-tion(1 0 1 2 60 2 0 )
文摘Cellular automata are the discrete dynamical systems of simple construction but with complex and varied behaviors.In this paper,the elementary cellular automaton of rule 22 is studied by the tools of formal language theory and symbolic dynamics.Its temporal evolution orbits are coarse grained into evolution sequences and the evolution languages are defined.It is proved that for every n ≥2 its width n evolution language is not regular.
文摘AIM: To study the effect of ginsenoside Rgl and Rhl on the anti - tumor activity of dendritic cells (DC). METHODS: Effect of Rgl and Rhl on the production of IL- 12 p40 protein was detected by ELISA, and the IL- 12 p40 mRNA level of DC was monitored by RT- PCR. Anti - tumor activity of DC- LPAK was detemnined by neutral red staining assay. RESULTS: The results of ELLSA showed that Rgl and Rhl significantly enhanced the production of IL- 12 p40 of DC. Rgl at 1 mg/L and Rhl at 100 mg/L upregulated the IL- 12 p40 mRNA level. Rgl and Rhl enhanced the anti - tumor ability of DC, induced lyrnphokine and PHA activated killer (DC-LPAK) on human papillate tumor cell line. Each dose of Rgl can obviously accelerate the eytotoxity to L929 at the E: T ratio of 5 : 1 (P<0.05,0.01 ), while only Rhl 10 mg/L enhanced the eytotoxity ability of DC- LPAK (P < 0.05). CONCLUSION: Rgl and Rhl enhanced the production of IL-12 p40. This effect may be mediated by the increase in the mRNA level. As a result, Rg1 and Rhl oromote the ability of DC to stimulate the cytotoxitie aetieity of DC - LPAK.
文摘墙,依托于凿洞为穴、构木为巢的原始居所,体现了人类最初的空间划分意识;后于“凿户牖以为室,当其无,有室之用,故有之以为利,无之以为用”中展示了人对“无”之意义的领悟。至此,人,坠入“树立-优化-消解”“墙”的循环往复中。在墙的意象内涵越来越丰富的背后,是人类对“墙”认知和解析的累积：关于“墙”本身,关于“墙”的场域,关于“墙”的隐喻。所以有柏林墙的建而又拆;所以有列侬墙的精神不倒;所以有Jackson对“off the wall”的歌咏。人对客观事物的改造往往托于“人”本身的视角,基于“人”的心理意象。人常说,一千个人心中有一千个哈姆雷特。换言之,意象经常是人改变客观事物并使其达至自己内心完美目标的心源。于是,我们想,见过、听说过各色各样的墙后,如果立足于心理意象重新再认知“墙”呢？这将会对“墙”的进化有什么样的意义呢？
文摘The multiglycosides of Triptvrygium wilfordii (GTW) was a male antifertility agvnt recently explorvd in China. In order to isolate the active principle from the drug, a couple of institutions have carried out work on phytochemical separation and
文摘Background Lipid abnormalities are often complicated by renal dysfunction. 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) are the first-line choice for lowering cholesterol levels. The present study was designed to investigate whether statins could prevent and invert the development of renal injury in cholesterol-fed rabbits and to find the possible mechanism of their effects by detecting gene and protein expression of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in the renal artery.Methods Twenty-four male New Zealand white rabbits were divided into three groups: (1) control group, regular granules chow; (2) HC-diet group, granules chow with 1% cholesterol and 5% lard oil; and (3) fluvastatin group, 1% cholesterol and 5% lard oil diet plus fluvastatin (10 mg·kg -1 ·d -1 ) . After 16 weeks, serum total cholesterol (TC), low-density lipoprotein(LDL) and creatinine (Cr) levels were measured. Renal hemodynamics and function, mainly including glomerular filtration rate (GFR) in vivo were quantified using 99m Tc-DTPA single photon emission computed tomograph ( 99m Tc-DTPA SPECT). The thickness of the renal artery intima was quantitated in HE-stained segments by histomorphometry. Gene expression of LOX-1 in the renal artery was examined by semi-quantitative RT-PCR and its protein expression was evaluated by immunohistochemistry.Results High cholesterol diet induced hypercholesterolemia (HC) complicated by renal dysfunction with increased levels of serum lipid and Cr, decreased GFR and delayed excretion and extensively thickened renal arterial intima in the HC-diet group. Rabbits in the control group showed a minimal LOX-1 expression (mRNA and protein) in the endothelium and neointima of the renal artery. Intimal proliferation of the renal artery in the HC-diet group was associated with a marked increase of LOX-1 expression (protein and mRNA). Treatment with fluvastatin improved renal function, attenuated intimal proliferation of the renal artery and markedly decreased the enhanced LOX-1 expression in the endothelium and neointima of the renal artery in rabbits. Conclusions Fuvastatin treatment could prevent the development of renal injury in patients with HC and early atherosclerosis (AS). This beneficial effect might be mediated by its pleiotropic effects including a decrease in total cholesterol exposure level and prevention of LOX-1 expression in atherosclerotic arteries.
