The process of selectively introducing a CF_(3) group into an organic molecule using inexpensive, stable, and solid sodium trifluoromethanesulfinate has rapidly advanced in recent years to become an eco-friendly metho...The process of selectively introducing a CF_(3) group into an organic molecule using inexpensive, stable, and solid sodium trifluoromethanesulfinate has rapidly advanced in recent years to become an eco-friendly method used by organic chemists to synthesize various natural and bioactive molecules. This review focuses on advances made within the last five years regarding C-H functionalisation, namely thermochemical C(sp^(2))-H (thio)trifluoromethylations, photochemical C(sp^(2))-H trifluoromethylations, and electrochemical C(sp^(2))-H trifluoromethylations, using Langlois’ reagent (NaSO_(2)CF_(3)).展开更多
Herein,a rapid alkenylation of quinoxalin-2(1H)-ones enabled by a combination of Mannich-type reaction and solar photocatalysis is demonstrated.A wide range of functional groups are compatible,affording the correspond...Herein,a rapid alkenylation of quinoxalin-2(1H)-ones enabled by a combination of Mannich-type reaction and solar photocatalysis is demonstrated.A wide range of functional groups are compatible,affording the corresponding products in moderate-to-good yields.Control experiments illustrate that the in situ generated^(1)O_(2)plays a central role in this reaction.This green and efficient strategy provides a practical solution for the synthesis of potentially bioactive compounds that containing a 3,4-dihydroquinoxalin-2(1H)-one structure.展开更多
Herein, an efficient molecular oxygen-mediated method for the selective hydroxyalkylation and alkylation of quinoxalin-2(1 H)-ones with alkylboronic acids under transition-metal free conditions has been developed. Thi...Herein, an efficient molecular oxygen-mediated method for the selective hydroxyalkylation and alkylation of quinoxalin-2(1 H)-ones with alkylboronic acids under transition-metal free conditions has been developed. This strategy demonstrates a broad scope of quinoxalin-2(1 H)-ones and alkylboronic acids, giving3-hydroxyalkylquinoxalin-2(1 H)-ones and 3-alkylquinoxalin-2(1 H)-ones in moderate-to-good yield. Control experiments reveal that a radical pathway is involved.展开更多
基金Natural Science Foundation of Zhejiang Province(No. LY21B060009) for financial support。
文摘The process of selectively introducing a CF_(3) group into an organic molecule using inexpensive, stable, and solid sodium trifluoromethanesulfinate has rapidly advanced in recent years to become an eco-friendly method used by organic chemists to synthesize various natural and bioactive molecules. This review focuses on advances made within the last five years regarding C-H functionalisation, namely thermochemical C(sp^(2))-H (thio)trifluoromethylations, photochemical C(sp^(2))-H trifluoromethylations, and electrochemical C(sp^(2))-H trifluoromethylations, using Langlois’ reagent (NaSO_(2)CF_(3)).
基金the Natural Science Foundation of Zhejiang Province(No.LY21B060009)the National Natural Science Foundation of China(No.21871071)for financial support.
文摘Herein,a rapid alkenylation of quinoxalin-2(1H)-ones enabled by a combination of Mannich-type reaction and solar photocatalysis is demonstrated.A wide range of functional groups are compatible,affording the corresponding products in moderate-to-good yields.Control experiments illustrate that the in situ generated^(1)O_(2)plays a central role in this reaction.This green and efficient strategy provides a practical solution for the synthesis of potentially bioactive compounds that containing a 3,4-dihydroquinoxalin-2(1H)-one structure.
基金Natural Science Foundation of Zhejiang Province(No. LY21B060009) for financial support。
文摘Herein, an efficient molecular oxygen-mediated method for the selective hydroxyalkylation and alkylation of quinoxalin-2(1 H)-ones with alkylboronic acids under transition-metal free conditions has been developed. This strategy demonstrates a broad scope of quinoxalin-2(1 H)-ones and alkylboronic acids, giving3-hydroxyalkylquinoxalin-2(1 H)-ones and 3-alkylquinoxalin-2(1 H)-ones in moderate-to-good yield. Control experiments reveal that a radical pathway is involved.
