Aqueous organic flow batteries have attracted dramatic attention for stationary energy storage due to their resource sustainability and low cost. However, the current reported systems can normally be operated stably u...Aqueous organic flow batteries have attracted dramatic attention for stationary energy storage due to their resource sustainability and low cost. However, the current reported systems can normally be operated stably under a nitrogen or argon atmosphere due to their poor stability. Herein a stable airinsensitive biphenol derivative cathode, 3,30,5,50-tetramethylaminemethylene-4,40-biphenol(TABP), with high solubility(>1.5 mol L^(-1)) and redox potential(0.91 V vs. SHE) is designed and synthesized by a scalable one-step method. Paring with silicotungstic acid(SWO), an SWO/TABP flow battery shows a stable performance of zero capacity decay over 900 cycles under the air atmosphere. Further, an SWO/TABP flow battery manifests a high rate performance with an energy efficiency of 85% at a current density of60 m A cm^(-2) and a very high volumetric capacity of more than 47 Ah L^(-1). This work provides a new and practical option for next-generation practical large-scale energy storage.展开更多
Natural products with significant biological activities continuously act as rich sources for drug discovery and development.To harness the potential of these valuable compounds,robust methods need to be developed for ...Natural products with significant biological activities continuously act as rich sources for drug discovery and development.To harness the potential of these valuable compounds,robust methods need to be developed for their rapid and sustainable production.Cell-free biosynthesis of pharmaceutical natural products by in vitro reconstruction of the entire biosynthetic pathways represents one such solution.In this review,we focus on in vitro biosynthesis of two important classes of natural products,polyketides(PKs)and nonribosomal peptides(NRPs).First,we summarize purified enzyme-based systems for the biosynthesis of PKs,NRPs,and PK/NRP hybrids.Then,we introduce the cell-free protein synthesis(CFPS)-based technology for natural product production.With that,we discuss challenges and opportunities of cell-free synthetic biology for in vitro biosynthesis of natural products.展开更多
基金The authors acknowledge financial support from the National Natural Science Foundation of China(21925804,21935003)CASDOE Collaborative Project(121421KYSB20170032)+1 种基金CAS Engineering Laboratory for Electrochemical Energy Storage,Liaoning Revitalization Talents Program(XLYC1802050)China and DICP funding,China(ZZBS201707)。
文摘Aqueous organic flow batteries have attracted dramatic attention for stationary energy storage due to their resource sustainability and low cost. However, the current reported systems can normally be operated stably under a nitrogen or argon atmosphere due to their poor stability. Herein a stable airinsensitive biphenol derivative cathode, 3,30,5,50-tetramethylaminemethylene-4,40-biphenol(TABP), with high solubility(>1.5 mol L^(-1)) and redox potential(0.91 V vs. SHE) is designed and synthesized by a scalable one-step method. Paring with silicotungstic acid(SWO), an SWO/TABP flow battery shows a stable performance of zero capacity decay over 900 cycles under the air atmosphere. Further, an SWO/TABP flow battery manifests a high rate performance with an energy efficiency of 85% at a current density of60 m A cm^(-2) and a very high volumetric capacity of more than 47 Ah L^(-1). This work provides a new and practical option for next-generation practical large-scale energy storage.
文摘Natural products with significant biological activities continuously act as rich sources for drug discovery and development.To harness the potential of these valuable compounds,robust methods need to be developed for their rapid and sustainable production.Cell-free biosynthesis of pharmaceutical natural products by in vitro reconstruction of the entire biosynthetic pathways represents one such solution.In this review,we focus on in vitro biosynthesis of two important classes of natural products,polyketides(PKs)and nonribosomal peptides(NRPs).First,we summarize purified enzyme-based systems for the biosynthesis of PKs,NRPs,and PK/NRP hybrids.Then,we introduce the cell-free protein synthesis(CFPS)-based technology for natural product production.With that,we discuss challenges and opportunities of cell-free synthetic biology for in vitro biosynthesis of natural products.
