Hepatocellular carcinoma(HCC)is the sixth most common malignancy and the fourth leading cause of cancer related death worldwide.China covers over half of cases,leading HCC to be a vital threaten to public health.Despi...Hepatocellular carcinoma(HCC)is the sixth most common malignancy and the fourth leading cause of cancer related death worldwide.China covers over half of cases,leading HCC to be a vital threaten to public health.Despite advances in diagnosis and treatments,high recurrence rate remains a major obstacle in HCC management.Multi-omics currently facilitates surveillance,precise diagnosis,and personalized treatment decision making in clinical setting.Non-invasive radiomics utilizes preoperative radiological imaging to reflect subtle pixel-level pattern changes that correlate to specific clinical outcomes.Radiomics has been widely used in histopathological diagnosis prediction,treatment response evaluation,and prognosis prediction.High-throughput sequencing and gene expression profiling enabled genomics and proteomics to identify distinct transcriptomic subclasses and recurrent genetic alterations in HCC,which would reveal the complex multistep process of the pathophysiology.The accumulation of big medical data and the development of artificial intelligence techniques are providing new insights for our better understanding of the mechanism of HCC via multi-omics,and show potential to convert surgical/intervention treatment into an antitumorigenic one,which would greatly advance precision medicine in HCC management.展开更多
Interleukin-26(IL-26),originally called AK155,is one of the cytokines of the IL-10 cytokine family,and its gene is located in human chromosome region 12q15.IL-26 signals through the receptors IL-20R1 and IL-10R2,which...Interleukin-26(IL-26),originally called AK155,is one of the cytokines of the IL-10 cytokine family,and its gene is located in human chromosome region 12q15.IL-26 signals through the receptors IL-20R1 and IL-10R2,which form a heterodimer,targets specific cells and induces activation of the JAK-STAT pathway,allowing the rapid phosphorylation of STAT1 and STAT3 and the initiation of their effects.1 This signaling plays an important role in the regulation of host defense and inflammatory diseases.However,whether the role of IL-26 in the progression of hepatocellular carcinoma(HCC)occurs via autophagy remains unclear.Here,we analyzed the association between IL-26 levels and the clinicopathological characteristics of 115 patients with HCC and found that IL-26 levels were particularly associated with tumor stage and survival.We found that IL-26 levels were associated with the prognosis of HCC patients.Furthermore,we found that increased autophagy by IL-26 was dependent on the JAK-STAT3 signaling pathway,which could result in the inhibition of the migration and invasion abilities of these HCC cells.These findings suggest that the levels of IL-26 may be a useful prognostic marker for HCC patients and may offer insights into the clinical application of IL-26 in the future.展开更多
文摘Hepatocellular carcinoma(HCC)is the sixth most common malignancy and the fourth leading cause of cancer related death worldwide.China covers over half of cases,leading HCC to be a vital threaten to public health.Despite advances in diagnosis and treatments,high recurrence rate remains a major obstacle in HCC management.Multi-omics currently facilitates surveillance,precise diagnosis,and personalized treatment decision making in clinical setting.Non-invasive radiomics utilizes preoperative radiological imaging to reflect subtle pixel-level pattern changes that correlate to specific clinical outcomes.Radiomics has been widely used in histopathological diagnosis prediction,treatment response evaluation,and prognosis prediction.High-throughput sequencing and gene expression profiling enabled genomics and proteomics to identify distinct transcriptomic subclasses and recurrent genetic alterations in HCC,which would reveal the complex multistep process of the pathophysiology.The accumulation of big medical data and the development of artificial intelligence techniques are providing new insights for our better understanding of the mechanism of HCC via multi-omics,and show potential to convert surgical/intervention treatment into an antitumorigenic one,which would greatly advance precision medicine in HCC management.
基金We appreciate the support from the National Natural Science Foundation of China(No.82073651 and 81973049)the University Synergy Innovation Program of Anhui Province(No.GXXT-2020-064)the Anhui Provincial Natural Science Foundation,China(No.1808085MH258)to fulfil this project.
文摘Interleukin-26(IL-26),originally called AK155,is one of the cytokines of the IL-10 cytokine family,and its gene is located in human chromosome region 12q15.IL-26 signals through the receptors IL-20R1 and IL-10R2,which form a heterodimer,targets specific cells and induces activation of the JAK-STAT pathway,allowing the rapid phosphorylation of STAT1 and STAT3 and the initiation of their effects.1 This signaling plays an important role in the regulation of host defense and inflammatory diseases.However,whether the role of IL-26 in the progression of hepatocellular carcinoma(HCC)occurs via autophagy remains unclear.Here,we analyzed the association between IL-26 levels and the clinicopathological characteristics of 115 patients with HCC and found that IL-26 levels were particularly associated with tumor stage and survival.We found that IL-26 levels were associated with the prognosis of HCC patients.Furthermore,we found that increased autophagy by IL-26 was dependent on the JAK-STAT3 signaling pathway,which could result in the inhibition of the migration and invasion abilities of these HCC cells.These findings suggest that the levels of IL-26 may be a useful prognostic marker for HCC patients and may offer insights into the clinical application of IL-26 in the future.
