We report a systematic investigation on the evolution of the structural and physical properties,including the charge density wave(CDW) and superconductivity of the polycrystalline CuIr_(2)Te_(4-x)Ix for 0.0 ≤x≤ 1.0....We report a systematic investigation on the evolution of the structural and physical properties,including the charge density wave(CDW) and superconductivity of the polycrystalline CuIr_(2)Te_(4-x)Ix for 0.0 ≤x≤ 1.0.Xray diffraction results indicate that both of a and c lattice parameters increase linearly when 0.0 ≤ x ≤ 1.0.The resistivity measurements indicate that the CDW is destabilized with slight x but reappears at x≥0.9 with very high TCDW.Meanwhile,the superconducting transition temperature Tc enhances as x increases and reaches a maximum value of around 2.95 K for the optimal composition CuIr_(2)Te_(1.9)I_(0.1) followed by a slight decrease with higher iodine doping content.The specific heat jump(ΔC/γTc) for the optimal composition CuIr_(2)Te_(3.9)I_(0.1) is approximately 1.46,which is close to the Bardeen-Cooper-Schrieffer value of 1.43,indicating that it is a bulk superconductor.The results of thermodynamic heat capacity measurements under different magnetic fields |Cp(T,H)],magnetization M(T,H) and magneto-transport ρ(T,H) measurements further suggest that CuIr_(2)Te_(4-x)Ix bulks are type-Ⅱ superconductors.Finally,an electronic phase diagram for this CuIr_(2)Te_(4-x)Ix system has been constructed.The present study provides a suitable material platform for further investigation of the interplay of the CDW and superconductivity.展开更多
Abnormal metabolism has become a potential target for highly malignant and invasive triple-negative breast cancer(TNBC)due to its relatively low response to traditional therapeutics.The existing metabolic intervention...Abnormal metabolism has become a potential target for highly malignant and invasive triple-negative breast cancer(TNBC)due to its relatively low response to traditional therapeutics.The existing metabolic interventions demonstrated unsatisfactory therapeutic outcomes and potential systemic toxicity,resulting from the metabolic instability and limited targeting ability of inhibitors as well as complex tumor microenvironment.To address these limitations,here we developed a robust pyroelectric BaTiO_(3)@Au core–shell nanostructure(BTO@Au)to selectively and persistently block energy generation of tumor cells.Stimulated by near-infrared(NIR)laser,the Au shell could generate heat to activate the BaTiO_(3)core to produce reactive oxygen species(ROS)regardless of the constrained microenvironment,thus prominently inhibits mitochondrial oxidative phosphorylation(OXPHOS)and reduces ATP production to induce TNBC cell apoptosis.The therapeutic effects have been well demonstrated in vitro and in vivo,paving a new way for the development of metabolic interventions.展开更多
基金Supported by the National Natural Science Foundation of China(Grants No.11922415)the Guangdong Basic and Applied Basic Research Foundation(Grants No.2019A1515011718)+10 种基金the Fundamental Research Funds for the Central Universities(Grants No.19lgzd03)the Key R&D Program of Guangdong Province,China(Grants No.2019B110209003)the Pearl River Scholarship Program of Guangdong Province Universities and Colleges(Grants No.20191001)supported by the National Natural Science Foundation of China(Grant No.12004441)the Hundreds of Talents Program of Sun Yat-Sen Universitythe Fundamental Research Funds for the Central Universities(Grants No.20lgpy165)supported by the National Natural Science Foundation of China(Grant No.11974432)NKRDPC-2017YFA0206203,and NKRDPC-2018YFA0306001supported by the National Nature Science Foundation of China(11904414)the Natural Science Foundation of Guangdong(2018A030313055)National Key Research and Development Program of China(Grants No.2019YFA0705700)。
文摘We report a systematic investigation on the evolution of the structural and physical properties,including the charge density wave(CDW) and superconductivity of the polycrystalline CuIr_(2)Te_(4-x)Ix for 0.0 ≤x≤ 1.0.Xray diffraction results indicate that both of a and c lattice parameters increase linearly when 0.0 ≤ x ≤ 1.0.The resistivity measurements indicate that the CDW is destabilized with slight x but reappears at x≥0.9 with very high TCDW.Meanwhile,the superconducting transition temperature Tc enhances as x increases and reaches a maximum value of around 2.95 K for the optimal composition CuIr_(2)Te_(1.9)I_(0.1) followed by a slight decrease with higher iodine doping content.The specific heat jump(ΔC/γTc) for the optimal composition CuIr_(2)Te_(3.9)I_(0.1) is approximately 1.46,which is close to the Bardeen-Cooper-Schrieffer value of 1.43,indicating that it is a bulk superconductor.The results of thermodynamic heat capacity measurements under different magnetic fields |Cp(T,H)],magnetization M(T,H) and magneto-transport ρ(T,H) measurements further suggest that CuIr_(2)Te_(4-x)Ix bulks are type-Ⅱ superconductors.Finally,an electronic phase diagram for this CuIr_(2)Te_(4-x)Ix system has been constructed.The present study provides a suitable material platform for further investigation of the interplay of the CDW and superconductivity.
基金supported by the National Natural Science Foundation of China(Nos.22007063 and 82002063)Shanxi Medical Key Science and Technology Project Plan of China(No.2020XM01)+4 种基金the National University of Singapore Start-up Grant(No.NUHSRO/2020/133/Startup/08)NUS School of Medicine Nanomedicine Translational Research Program(No.NUHSRO/2021/034/TRP/09/Nanomedicine)the Science Research Start-up Fund for Doctor of Shanxi Province(No.XD1809 and XD2011)the Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi(No.2019L0414)Shanxi Province Science Foundation for Youths(No.201901D211316).
文摘Abnormal metabolism has become a potential target for highly malignant and invasive triple-negative breast cancer(TNBC)due to its relatively low response to traditional therapeutics.The existing metabolic interventions demonstrated unsatisfactory therapeutic outcomes and potential systemic toxicity,resulting from the metabolic instability and limited targeting ability of inhibitors as well as complex tumor microenvironment.To address these limitations,here we developed a robust pyroelectric BaTiO_(3)@Au core–shell nanostructure(BTO@Au)to selectively and persistently block energy generation of tumor cells.Stimulated by near-infrared(NIR)laser,the Au shell could generate heat to activate the BaTiO_(3)core to produce reactive oxygen species(ROS)regardless of the constrained microenvironment,thus prominently inhibits mitochondrial oxidative phosphorylation(OXPHOS)and reduces ATP production to induce TNBC cell apoptosis.The therapeutic effects have been well demonstrated in vitro and in vivo,paving a new way for the development of metabolic interventions.