Several 6-aminoquinoline derivatives,which could be used in drug design,have been synthesized.The reaction conditions were comparatively studied,and the p-chloroaniline was used as optimum oxidant in Skraup-Doebner-Vo...Several 6-aminoquinoline derivatives,which could be used in drug design,have been synthesized.The reaction conditions were comparatively studied,and the p-chloroaniline was used as optimum oxidant in Skraup-Doebner-Von Miller reaction.The nitro group was reduced effectively by SnCl2 with no halo-removed occurred.展开更多
基金the financial support of this work by the National Science Foundation of China(No 20776085)the 973 Program of China(No2007CB209700)+2 种基金the STCSM of China(Nos10JC1406900 and 09XD1402400)the Foundation of Zhejiang Pharmaceutics CoLtd the Opening Foundation of Zhejiang Provincial Top Key Discipline
文摘Several 6-aminoquinoline derivatives,which could be used in drug design,have been synthesized.The reaction conditions were comparatively studied,and the p-chloroaniline was used as optimum oxidant in Skraup-Doebner-Von Miller reaction.The nitro group was reduced effectively by SnCl2 with no halo-removed occurred.
