Mn-rich LiFe_(1-x)Mn_(x)PO_(4)(x>0.5),which combines the high operation voltage of LiMnPO_(4)with excellent rate performa nce of LiFePO4,is hindered by its sluggish kinetic properties.Herein,thermodynamic equilibri...Mn-rich LiFe_(1-x)Mn_(x)PO_(4)(x>0.5),which combines the high operation voltage of LiMnPO_(4)with excellent rate performa nce of LiFePO4,is hindered by its sluggish kinetic properties.Herein,thermodynamic equilibrium analysis of Mn^(2+)-Fe^(2+)-Mg^(2+)-C_(2)O_(4)^(2-)-H_(2)O system is used to guide the design and preparation of insitu Mg-doped(Fe_(0.4)Mn_(0.6))_(1-x)Mg_(x)C_(2)O_(4)intermediate,which is then employed as an innovative precursor to synthesize high-performance Mg-doped LiFe_(0.4)Mn_(0.6)PO_(4).It indicates that the metal ions with a high precipitation efficiency and the stoichiometric precursors with uniform element distribution can be achieved under the optimized thermodynamic conditions.Meanwhile,accelerated Li+diffusivity and reduced charge transfer resistance originating from Mg doping are verified by various kinetic characterizations.Benefiting from the contributions of inherited homogeneous element distribution,small particle size,uniform carbon layer coating,enhanced Li+migration ability and structural stability induced by Mg doping,the Li(Fe_(0.4)Mn_(0.6))_(0.97)Mg_(0.03)PO_(4)/C exhibits splendid electrochemical performance.展开更多
Image/video stitching is a technology for solving the field of view(FOV)limitation of images/videos.It stitches multiple overlapping images/videos to generate a wide-FOV image/video,and has been used in various fields...Image/video stitching is a technology for solving the field of view(FOV)limitation of images/videos.It stitches multiple overlapping images/videos to generate a wide-FOV image/video,and has been used in various fields such as sports broadcasting,video surveillance,street view,and entertainment.This survey reviews image/video stitching algorithms,with a particular focus on those developed in recent years.Image stitching first calculates the corresponding relationships between multiple overlapping images,deforms and aligns the matched images,and then blends the aligned images to generate a wide-FOV image.A seamless method is always adopted to eliminate such potential flaws as ghosting and blurring caused by parallax or objects moving across the overlapping regions.Video stitching is the further extension of image stitching.It usually stitches selected frames of original videos to generate a stitching template by performing image stitching algorithms,and the subsequent frames can then be stitched according to the template.Video stitching is more complicated with moving objects or violent camera movement,because these factors introduce jitter,shakiness,ghosting,and blurring.Foreground detection technique is usually combined into stitching to eliminate ghosting and blurring,while video stabilization algorithms are adopted to solve the jitter and shakiness.This paper further discusses panoramic stitching as a special-extension of image/video stitching.Panoramic stitching is currently the most widely used application in stitching.This survey reviews the latest image/video stitching methods,and introduces the fundamental principles/advantages/weaknesses of image/video stitching algorithms.Image/video stitching faces long-term challenges such as wide baseline,large parallax,and low-texture problem in the overlapping region.New technologies may present new opportunities to address these issues,such as deep learning-based semantic correspondence,and 3D image stitching.Finally,this survey discusses the challenges of image/video stitching and proposes potential solutions.展开更多
Objective: To investigate the effects of montelukast sodium combined with budesonide on pulmonary function, inflammatory factors and immunoglobulin in children with asthma. Methods: A total of 100 children with asthma...Objective: To investigate the effects of montelukast sodium combined with budesonide on pulmonary function, inflammatory factors and immunoglobulin in children with asthma. Methods: A total of 100 children with asthma treated in our hospital from May 2013 to November 2016 were randomly divided into control group and observation group. In the control group, budesonide inhalation therapy was given. On the basis of the control group, montelukast sodium treatment was given, pulmonary function, inflammatory factors and immunoglobulin levels in the two groups before and after treatment were measured. Results:Compared with before treatment, the levels of FEV1%, FEF50%, FEF25% and PEF% in the two groups were significantly increased, those in the observation group were higher than in control group;compared with before treatment, IL-10 levels were significantly increased, TNF-α and IL-8 levels were significantly decreased in the two groups after treatment, moreover those in the observation group IL-10 levels were significantly higher than the control group, TNF-α and IL-8 were significantly lower than those in the control group, the difference was statistically significant;Compared with before treatment, IgA and IgM levels were significantly increased in both groups after treatment, IgE levels were significantly decreased, and IgA and IgM levels in the observation group were significantly higher than in the control group, IgE levels were significantly lower than the control group, the difference was statistically. Conclusion: Montelukast sodium combined with budesonide can effectively reduce the inflammation level of children with asthma, improve lung function, enhance immunity, the effect is significant, it is worth further clinical application.展开更多
[Objectives]This study was conducted to investigate the extraction process of quiona(Cheuopodium quinoa)leaves.[Methods]Firstly,single factor experiments were carried out with the volume fraction of ethanol,extraction...[Objectives]This study was conducted to investigate the extraction process of quiona(Cheuopodium quinoa)leaves.[Methods]Firstly,single factor experiments were carried out with the volume fraction of ethanol,extraction time,extraction temperature and liquid-to-material ratio as factors.Based on the single factor experiments,a response surface test was designed by the central composite design method of Design-Expert software to establish a mathematical model.[Results]The optimal extraction conditions of quinoa flavonoids were obtained as follows:the ethanol volume fraction of 70%,the liquid-to-material ratio at 30∶1,the extraction time of 100 min and the extraction temperature at 60℃.[Conclusions]The results of the study are stable with small deviation,and can provide reference for related processes.展开更多
Light carries energy and momentum,laying the physical foundation of optical manipulation that has facilitated advances in myriad scientific disciplines,ranging from biochemistry and robotics to quantum physics.Utilizi...Light carries energy and momentum,laying the physical foundation of optical manipulation that has facilitated advances in myriad scientific disciplines,ranging from biochemistry and robotics to quantum physics.Utilizing the momentum of light,optical tweezers have exemplified elegant light–matter interactions in which mechanical and optical momenta can be interchanged,whose effects are the most pronounced on micro and nano objects in fluid suspensions.In solid domains,the same momentum transfer becomes futile in the face of dramatically increased adhesion force.Effective implementation of optical manipulation should thereupon switch to the“energy”channel by involving auxiliary physical fields,which also coincides with the irresistible trend of enriching actuation mechanisms beyond sole reliance on light-momentum-based optical force.From this perspective,this review covers the developments of optical manipulation in schemes of both momentum and energy transfer,and we have correspondingly selected representative techniques to present.Theoretical analyses are provided at the beginning of this review followed by experimental embodiments,with special emphasis on the contrast between mechanisms and the practical realization of optical manipulation in fluid and solid domains.展开更多
Durable superamphiphobic surfaces are highly desired for real-world applications such as self-cleaning,anti-fouling,personal protection,and functional sportswear.However,challenges still exist in constructing robust s...Durable superamphiphobic surfaces are highly desired for real-world applications such as self-cleaning,anti-fouling,personal protection,and functional sportswear.However,challenges still exist in constructing robust superamphiphobic surfaces by using short-fluorinated polymers as one of the promising alternatives for environmentally unfriendly long perfluorinated side-chain polymers.Hierarchical patterns on biological skins endow the creatures with a specific surface for survival.Here,a facile strategy was proposed to generate hierarchical wrinkles for ultradurable superamphiphobic fabrics by simulating the deformation adaptability of snakeskin.Snake-like hierarchical winkling was constructed by the infusion of reactive perfluorooctyltriethoxysilane(FOS)in a wet chemical plus vapor polymerization process.Upon the infusion of FOS,the mismatch of shrinkage caused by gradient crosslinking leads to the formation of a soft wrinkled poly(perfluorooctyl trieth-oxysilane)(poly-FOS)surface.Such a snakeskin-like hierarchical wrinkled surface and high fluorine density of poly-FOS endowed the treated superamphiphobic fabrics with high water resistance(contact angle 169°),castor oil resistance(154°),and extraordinary durability(withstanding 100 standard laundries,15,000 rubbing cycles and strong acid and alkali solu-tions).Moreover,a superamphiphobic surface can be formed on various substrates,including fabric,wood,paper,and glass.This work thus gives new insights into the environmentally friendly manufacture of ultradurable superamphiphobic fabrics.展开更多
For spacecraft working in vacuum environment, sublimator is an effective heat rejection approach to reject system's peak heat load, and supplement spacecraft radiation heat rejection. For a spacecraft active fluid...For spacecraft working in vacuum environment, sublimator is an effective heat rejection approach to reject system's peak heat load, and supplement spacecraft radiation heat rejection. For a spacecraft active fluid loop thermal control system combined with sublimator, waste heat generated from multi-point distributed heat sources could be collected by the fluid loop efficiently. However, the heat and mass transfer performances of the sublimator combined with fluid loop have not been adequately studied in previous research, especially for the influences of the heat load. Since work fluid mass flow rate is the main factor affecting heat load of the fluid loop, this context experimentally studied influences of the fluid loop mass flow rate on sublimator start-up transient characteristics, including heat transfer performances, response time, and work stability. Results indicated that the fluid loop mass flow rate affected the sublimator heat and mass transfer performances obviously, but the heat rejection ability is not always increase with the increasing of the fluid loop mass flow rate. In addition, we obtained the condition to judge whether there is a positive correlation between heat rejection ability and fluid loop mass flow rate.展开更多
Tumor-induced osteomalacia(TIO)is a rare paraneoplastic syndrome caused by excessive fibroblast growth factor 23(FGF23)production by a tumor,which often arises from a mesenchymal origin.[1-3]Most clinical symptoms of ...Tumor-induced osteomalacia(TIO)is a rare paraneoplastic syndrome caused by excessive fibroblast growth factor 23(FGF23)production by a tumor,which often arises from a mesenchymal origin.[1-3]Most clinical symptoms of TIO are the consequences of prolonged FGF23-mediated hypophosphatemia as muscle weakness,bone pain,impaired mobility,and fractures.[4]Clinical diagnosis and management of TIO are challenging because knowledge about this condition is still restricted to a few specialized centers,leading to delay in diagnosis and appropriate treatment.The scope of the present consensus is to provide up-to-date guidance on the assessment and treatment of TIO.展开更多
The patients w让h acquired immunodeficiency syndrome(AIDS)are prone to opportunistic infections due to immune deficiencies.Because the AIDS virus is neuropathic,10%of AIDS patients first manifested central nervous sys...The patients w让h acquired immunodeficiency syndrome(AIDS)are prone to opportunistic infections due to immune deficiencies.Because the AIDS virus is neuropathic,10%of AIDS patients first manifested central nervous system(CNS)symptoms.111 More than 40% of untreated AIDS patients will develop CNS diseases.121 The diagnosis and treatment for AIDS complicated with intracranial lesions are mainly based on clinical experience and laboratory tests.If necessary,brain biopsies were taken into consideration to help to diagnose and choose a suitable therapy.In clinic practice,to get a specific diagnosis is very difficult.To further analyze the clinical features of such patients and to provide some suggestions for the clinical diagnosis and treatments,we retrospectively analyzed three AIDS cases with CNS infection who attended the Peking Union Medical College Hospital.展开更多
We propose a novel Laplacian-based algorithm that simplifies triangle surface meshes and can provide different preservation ratios of geometric features.Our efficient and fast algorithm uses a 3D mesh model as input a...We propose a novel Laplacian-based algorithm that simplifies triangle surface meshes and can provide different preservation ratios of geometric features.Our efficient and fast algorithm uses a 3D mesh model as input and initially detects geometric features by using a Laplacian-based shape descriptor(L-descriptor).The algorithm further performs an optimized clustering approach that combines a Laplacian operator with K-means clustering algorithm to perform vertex classification.Moreover,we introduce a Laplacian weighted cost function based on L-descriptor to perform feature weighting and error statistics comparison,which are further used to change the deletion order of the model elements and preserve the saliency features.Our algorithm can provide different preservation ratios of geometric features and may be extended to handle arbitrary mesh topologies.Our experiments on a variety of 3D surface meshes demonstrate the advantages of our algorithm in terms of improving accuracy and applicability,and preserving saliency geometric features.展开更多
Realizing optical manipulation of microscopic objects is crucial in the research fields of life science,condensed matter physics,and physical chemistry.In non-liquid environments,this task is commonly regarded as diff...Realizing optical manipulation of microscopic objects is crucial in the research fields of life science,condensed matter physics,and physical chemistry.In non-liquid environments,this task is commonly regarded as difficult due to strong adhesive surface force(~µN)attached to solid interfaces that makes tiny optical driven force(~pN)insignificant.Here,by recognizing the microscopic interaction mechanism between friction force—the parallel component of surface force on a contact surface—and thermoelastic waves induced by pulsed optical absorption,we establish a general principle enabling the actuation of micro-objects on dry frictional surfaces based on the opto-thermo-mechanical effects.Theoretically,we predict that nanosecond pulsed optical absorption with mW-scale peak power is sufficient to tameµN-scale friction force.Experimentally,we demonstrate the two-dimensional spiral motion of gold plates on micro-fibers driven by nanosecond laser pulses,and reveal the rules of motion control.Our results pave the way for the future development of micro-scale actuators in non-liquid environments.展开更多
Massive multiple-input multiple-output (MIMO), small cell, and full-duplex are promising techniques for future 5G communication systems, where interference has become the most challenging issue to be addressed.In this...Massive multiple-input multiple-output (MIMO), small cell, and full-duplex are promising techniques for future 5G communication systems, where interference has become the most challenging issue to be addressed.In this paper, we provide an interference coordination framework for a two-tier heterogeneous network(HetNet)that consists of a massive-MIMO enabled macro-cell base station (MBS) and a number of full-duplex small-cell base stations (SBSs). To suppress the interferences and maximize the throughput, the full-duplex mode of each SBS at the wireless backhaul link (i.e., in-band or out-of-band), which has a different impact on the interference pattern, should be carefully selected. To address this problem, we propose two centralized algorithms, a genetic algorithm (GEA)and a greedy algorithm (GRA). To sufficiently reduce the computational overhead of the MBS, a distributed graph coloring algorithm (DGCA) based on price is further proposed. Numerical results demonstrate that the proposed algorithms significantly improve the system throughput.展开更多
To meet the requirement of extensive resection of pancreatic cancer with portal or mesenteric venous invasion,the innovation of Vascular Graft Bridged En Bloc Resection (VGBEBR) has been adopted to treat advanced bi...To meet the requirement of extensive resection of pancreatic cancer with portal or mesenteric venous invasion,the innovation of Vascular Graft Bridged En Bloc Resection (VGBEBR) has been adopted to treat advanced biliopancreatic cancer in the Department of Hepatobiliary Surgery of the PLA Rocket Force General Hospital since 2013.This attempt could not only broaden surgical indications of radical resection and lymphadenectomy but also increase R0 resection rate,especially for the case with severe invasion in the portal and mesenteric venous system.展开更多
Prolonged antiretroviral therapy(ART)-free remission post-treatment has been observed and reported in human immunodeficiency virus-1(HIV-1)infection.The primary factors for such achievement have been linked to the tra...Prolonged antiretroviral therapy(ART)-free remission post-treatment has been observed and reported in human immunodeficiency virus-1(HIV-1)infection.The primary factors for such achievement have been linked to the transcriptional inactivation of HIV-1 DNA and immune recovery.Here,we reported a patient with acute HIV-1 infection who immediately received intensified quadruple ART.At month 9(M9),an old CFDA-approved immuno-suppressive herbal medicine,Tripterygium Wilfordii Hook F(TwHF),was used in addition to ART.The patient was closely monitored.Virological and immunological tests as well as transcriptome analysis were carried out at each visit.The results showed that TwHF reduced serum IP-10 level and inhibited T cell activation.Both ART and TwHF were discontinued in M24,and levels of peripheral blood HIV-1 RNA and DNA remained suppressed for consecutive 12months.With transcriptome analysis,we found pattern changes linking immuno-activation and amino acid metabolism with viral suppression and rebound.This indicates that the intentional suppression of immuno-activation is a promising approach for a functional cure of HIV-1 infection.展开更多
基金financially supported by the National Natural Science Foundation of China(No.51904250)the China Postdoctoral Science Foundation(No.2021M692254)+2 种基金the Sichuan Science and Technology Program(No.2022YFG0098)the Fundamental Research Funds for the Central Universities(Nos.2021CDSN-02,2022SCU12002,2022CDZG-17,2022CDSN-08,2022CDZG-9)the Hohhot Science and Technology Program(No.2023-Jie Bang Gua Shuai-Gao-3)。
文摘Mn-rich LiFe_(1-x)Mn_(x)PO_(4)(x>0.5),which combines the high operation voltage of LiMnPO_(4)with excellent rate performa nce of LiFePO4,is hindered by its sluggish kinetic properties.Herein,thermodynamic equilibrium analysis of Mn^(2+)-Fe^(2+)-Mg^(2+)-C_(2)O_(4)^(2-)-H_(2)O system is used to guide the design and preparation of insitu Mg-doped(Fe_(0.4)Mn_(0.6))_(1-x)Mg_(x)C_(2)O_(4)intermediate,which is then employed as an innovative precursor to synthesize high-performance Mg-doped LiFe_(0.4)Mn_(0.6)PO_(4).It indicates that the metal ions with a high precipitation efficiency and the stoichiometric precursors with uniform element distribution can be achieved under the optimized thermodynamic conditions.Meanwhile,accelerated Li+diffusivity and reduced charge transfer resistance originating from Mg doping are verified by various kinetic characterizations.Benefiting from the contributions of inherited homogeneous element distribution,small particle size,uniform carbon layer coating,enhanced Li+migration ability and structural stability induced by Mg doping,the Li(Fe_(0.4)Mn_(0.6))_(0.97)Mg_(0.03)PO_(4)/C exhibits splendid electrochemical performance.
基金the National Natural Science Foundation of China(61872023).
文摘Image/video stitching is a technology for solving the field of view(FOV)limitation of images/videos.It stitches multiple overlapping images/videos to generate a wide-FOV image/video,and has been used in various fields such as sports broadcasting,video surveillance,street view,and entertainment.This survey reviews image/video stitching algorithms,with a particular focus on those developed in recent years.Image stitching first calculates the corresponding relationships between multiple overlapping images,deforms and aligns the matched images,and then blends the aligned images to generate a wide-FOV image.A seamless method is always adopted to eliminate such potential flaws as ghosting and blurring caused by parallax or objects moving across the overlapping regions.Video stitching is the further extension of image stitching.It usually stitches selected frames of original videos to generate a stitching template by performing image stitching algorithms,and the subsequent frames can then be stitched according to the template.Video stitching is more complicated with moving objects or violent camera movement,because these factors introduce jitter,shakiness,ghosting,and blurring.Foreground detection technique is usually combined into stitching to eliminate ghosting and blurring,while video stabilization algorithms are adopted to solve the jitter and shakiness.This paper further discusses panoramic stitching as a special-extension of image/video stitching.Panoramic stitching is currently the most widely used application in stitching.This survey reviews the latest image/video stitching methods,and introduces the fundamental principles/advantages/weaknesses of image/video stitching algorithms.Image/video stitching faces long-term challenges such as wide baseline,large parallax,and low-texture problem in the overlapping region.New technologies may present new opportunities to address these issues,such as deep learning-based semantic correspondence,and 3D image stitching.Finally,this survey discusses the challenges of image/video stitching and proposes potential solutions.
文摘Objective: To investigate the effects of montelukast sodium combined with budesonide on pulmonary function, inflammatory factors and immunoglobulin in children with asthma. Methods: A total of 100 children with asthma treated in our hospital from May 2013 to November 2016 were randomly divided into control group and observation group. In the control group, budesonide inhalation therapy was given. On the basis of the control group, montelukast sodium treatment was given, pulmonary function, inflammatory factors and immunoglobulin levels in the two groups before and after treatment were measured. Results:Compared with before treatment, the levels of FEV1%, FEF50%, FEF25% and PEF% in the two groups were significantly increased, those in the observation group were higher than in control group;compared with before treatment, IL-10 levels were significantly increased, TNF-α and IL-8 levels were significantly decreased in the two groups after treatment, moreover those in the observation group IL-10 levels were significantly higher than the control group, TNF-α and IL-8 were significantly lower than those in the control group, the difference was statistically significant;Compared with before treatment, IgA and IgM levels were significantly increased in both groups after treatment, IgE levels were significantly decreased, and IgA and IgM levels in the observation group were significantly higher than in the control group, IgE levels were significantly lower than the control group, the difference was statistically. Conclusion: Montelukast sodium combined with budesonide can effectively reduce the inflammation level of children with asthma, improve lung function, enhance immunity, the effect is significant, it is worth further clinical application.
基金Supported by Shijiazhuang Science and Technology Bureau Project(181490058A)Project of Hebei Academy of Agriculture and Forestry Sciences(F19R494004-01-5)(2018030302)
文摘[Objectives]This study was conducted to investigate the extraction process of quiona(Cheuopodium quinoa)leaves.[Methods]Firstly,single factor experiments were carried out with the volume fraction of ethanol,extraction time,extraction temperature and liquid-to-material ratio as factors.Based on the single factor experiments,a response surface test was designed by the central composite design method of Design-Expert software to establish a mathematical model.[Results]The optimal extraction conditions of quinoa flavonoids were obtained as follows:the ethanol volume fraction of 70%,the liquid-to-material ratio at 30∶1,the extraction time of 100 min and the extraction temperature at 60℃.[Conclusions]The results of the study are stable with small deviation,and can provide reference for related processes.
基金supported by the National Natural Science Foundation of China (Nos.61927820,61905201,and 62275221).
文摘Light carries energy and momentum,laying the physical foundation of optical manipulation that has facilitated advances in myriad scientific disciplines,ranging from biochemistry and robotics to quantum physics.Utilizing the momentum of light,optical tweezers have exemplified elegant light–matter interactions in which mechanical and optical momenta can be interchanged,whose effects are the most pronounced on micro and nano objects in fluid suspensions.In solid domains,the same momentum transfer becomes futile in the face of dramatically increased adhesion force.Effective implementation of optical manipulation should thereupon switch to the“energy”channel by involving auxiliary physical fields,which also coincides with the irresistible trend of enriching actuation mechanisms beyond sole reliance on light-momentum-based optical force.From this perspective,this review covers the developments of optical manipulation in schemes of both momentum and energy transfer,and we have correspondingly selected representative techniques to present.Theoretical analyses are provided at the beginning of this review followed by experimental embodiments,with special emphasis on the contrast between mechanisms and the practical realization of optical manipulation in fluid and solid domains.
基金support of the National Natural Science Foundation of China(52073046,51873036,51673039,and 52103106)the Program of Shanghai Academic Leader(21XD1420200)+1 种基金the Chang Jiang Scholar Program(Q2019152)the Shanghai Shuguang Program(19SG28).
文摘Durable superamphiphobic surfaces are highly desired for real-world applications such as self-cleaning,anti-fouling,personal protection,and functional sportswear.However,challenges still exist in constructing robust superamphiphobic surfaces by using short-fluorinated polymers as one of the promising alternatives for environmentally unfriendly long perfluorinated side-chain polymers.Hierarchical patterns on biological skins endow the creatures with a specific surface for survival.Here,a facile strategy was proposed to generate hierarchical wrinkles for ultradurable superamphiphobic fabrics by simulating the deformation adaptability of snakeskin.Snake-like hierarchical winkling was constructed by the infusion of reactive perfluorooctyltriethoxysilane(FOS)in a wet chemical plus vapor polymerization process.Upon the infusion of FOS,the mismatch of shrinkage caused by gradient crosslinking leads to the formation of a soft wrinkled poly(perfluorooctyl trieth-oxysilane)(poly-FOS)surface.Such a snakeskin-like hierarchical wrinkled surface and high fluorine density of poly-FOS endowed the treated superamphiphobic fabrics with high water resistance(contact angle 169°),castor oil resistance(154°),and extraordinary durability(withstanding 100 standard laundries,15,000 rubbing cycles and strong acid and alkali solu-tions).Moreover,a superamphiphobic surface can be formed on various substrates,including fabric,wood,paper,and glass.This work thus gives new insights into the environmentally friendly manufacture of ultradurable superamphiphobic fabrics.
基金supports of the National Natural Science Foundation of China(No.11472040)the National Science Technology Major Project of China
文摘For spacecraft working in vacuum environment, sublimator is an effective heat rejection approach to reject system's peak heat load, and supplement spacecraft radiation heat rejection. For a spacecraft active fluid loop thermal control system combined with sublimator, waste heat generated from multi-point distributed heat sources could be collected by the fluid loop efficiently. However, the heat and mass transfer performances of the sublimator combined with fluid loop have not been adequately studied in previous research, especially for the influences of the heat load. Since work fluid mass flow rate is the main factor affecting heat load of the fluid loop, this context experimentally studied influences of the fluid loop mass flow rate on sublimator start-up transient characteristics, including heat transfer performances, response time, and work stability. Results indicated that the fluid loop mass flow rate affected the sublimator heat and mass transfer performances obviously, but the heat rejection ability is not always increase with the increasing of the fluid loop mass flow rate. In addition, we obtained the condition to judge whether there is a positive correlation between heat rejection ability and fluid loop mass flow rate.
基金by grants from the CAMS Innovation Fund for Medical Science(No.2016-I2M-3-003)the National Natural Science Foundation of China(No.81970757 and No.81670714).
文摘Tumor-induced osteomalacia(TIO)is a rare paraneoplastic syndrome caused by excessive fibroblast growth factor 23(FGF23)production by a tumor,which often arises from a mesenchymal origin.[1-3]Most clinical symptoms of TIO are the consequences of prolonged FGF23-mediated hypophosphatemia as muscle weakness,bone pain,impaired mobility,and fractures.[4]Clinical diagnosis and management of TIO are challenging because knowledge about this condition is still restricted to a few specialized centers,leading to delay in diagnosis and appropriate treatment.The scope of the present consensus is to provide up-to-date guidance on the assessment and treatment of TIO.
文摘The patients w让h acquired immunodeficiency syndrome(AIDS)are prone to opportunistic infections due to immune deficiencies.Because the AIDS virus is neuropathic,10%of AIDS patients first manifested central nervous system(CNS)symptoms.111 More than 40% of untreated AIDS patients will develop CNS diseases.121 The diagnosis and treatment for AIDS complicated with intracranial lesions are mainly based on clinical experience and laboratory tests.If necessary,brain biopsies were taken into consideration to help to diagnose and choose a suitable therapy.In clinic practice,to get a specific diagnosis is very difficult.To further analyze the clinical features of such patients and to provide some suggestions for the clinical diagnosis and treatments,we retrospectively analyzed three AIDS cases with CNS infection who attended the Peking Union Medical College Hospital.
基金This work has been financially supported by the National High Technology Research and Development Program of China(863 Program)(www.nsfc.gov.cn,No.2015AA016403)the National Natural Science Foundation of China(www.nsfc.gov.cn,No.61602223).
文摘We propose a novel Laplacian-based algorithm that simplifies triangle surface meshes and can provide different preservation ratios of geometric features.Our efficient and fast algorithm uses a 3D mesh model as input and initially detects geometric features by using a Laplacian-based shape descriptor(L-descriptor).The algorithm further performs an optimized clustering approach that combines a Laplacian operator with K-means clustering algorithm to perform vertex classification.Moreover,we introduce a Laplacian weighted cost function based on L-descriptor to perform feature weighting and error statistics comparison,which are further used to change the deletion order of the model elements and preserve the saliency features.Our algorithm can provide different preservation ratios of geometric features and may be extended to handle arbitrary mesh topologies.Our experiments on a variety of 3D surface meshes demonstrate the advantages of our algorithm in terms of improving accuracy and applicability,and preserving saliency geometric features.
基金This project was supported by the National Key Research and Development Program of China(2017YFA0205700)the National Natural Science Foundation of China(61927820,61905201,12004313)the China Postdoctoral Science Foundation(2020M671809)。
文摘Realizing optical manipulation of microscopic objects is crucial in the research fields of life science,condensed matter physics,and physical chemistry.In non-liquid environments,this task is commonly regarded as difficult due to strong adhesive surface force(~µN)attached to solid interfaces that makes tiny optical driven force(~pN)insignificant.Here,by recognizing the microscopic interaction mechanism between friction force—the parallel component of surface force on a contact surface—and thermoelastic waves induced by pulsed optical absorption,we establish a general principle enabling the actuation of micro-objects on dry frictional surfaces based on the opto-thermo-mechanical effects.Theoretically,we predict that nanosecond pulsed optical absorption with mW-scale peak power is sufficient to tameµN-scale friction force.Experimentally,we demonstrate the two-dimensional spiral motion of gold plates on micro-fibers driven by nanosecond laser pulses,and reveal the rules of motion control.Our results pave the way for the future development of micro-scale actuators in non-liquid environments.
基金supported by the National High-Tech R&D Program(863)of China(No.2014AA01A702)the National Natural Science Foundation of China(No.61371094)
文摘Massive multiple-input multiple-output (MIMO), small cell, and full-duplex are promising techniques for future 5G communication systems, where interference has become the most challenging issue to be addressed.In this paper, we provide an interference coordination framework for a two-tier heterogeneous network(HetNet)that consists of a massive-MIMO enabled macro-cell base station (MBS) and a number of full-duplex small-cell base stations (SBSs). To suppress the interferences and maximize the throughput, the full-duplex mode of each SBS at the wireless backhaul link (i.e., in-band or out-of-band), which has a different impact on the interference pattern, should be carefully selected. To address this problem, we propose two centralized algorithms, a genetic algorithm (GEA)and a greedy algorithm (GRA). To sufficiently reduce the computational overhead of the MBS, a distributed graph coloring algorithm (DGCA) based on price is further proposed. Numerical results demonstrate that the proposed algorithms significantly improve the system throughput.
文摘To meet the requirement of extensive resection of pancreatic cancer with portal or mesenteric venous invasion,the innovation of Vascular Graft Bridged En Bloc Resection (VGBEBR) has been adopted to treat advanced biliopancreatic cancer in the Department of Hepatobiliary Surgery of the PLA Rocket Force General Hospital since 2013.This attempt could not only broaden surgical indications of radical resection and lymphadenectomy but also increase R0 resection rate,especially for the case with severe invasion in the portal and mesenteric venous system.
基金This study was supported by the National Natural Science Foundation of China(No.81601777)National Key Technologies R&D Program for the 13th Five-year Plan(No.2017ZX10202101,2018ZX10732101-002)the CAMS Initiative for Innovative Medicine(CAMS-I2M:2017-I2M-1-014).
文摘Prolonged antiretroviral therapy(ART)-free remission post-treatment has been observed and reported in human immunodeficiency virus-1(HIV-1)infection.The primary factors for such achievement have been linked to the transcriptional inactivation of HIV-1 DNA and immune recovery.Here,we reported a patient with acute HIV-1 infection who immediately received intensified quadruple ART.At month 9(M9),an old CFDA-approved immuno-suppressive herbal medicine,Tripterygium Wilfordii Hook F(TwHF),was used in addition to ART.The patient was closely monitored.Virological and immunological tests as well as transcriptome analysis were carried out at each visit.The results showed that TwHF reduced serum IP-10 level and inhibited T cell activation.Both ART and TwHF were discontinued in M24,and levels of peripheral blood HIV-1 RNA and DNA remained suppressed for consecutive 12months.With transcriptome analysis,we found pattern changes linking immuno-activation and amino acid metabolism with viral suppression and rebound.This indicates that the intentional suppression of immuno-activation is a promising approach for a functional cure of HIV-1 infection.