Asymmetric conjugated addition of allylcopper reagents derived from an allyl Grignard reagent and CuBr·Me_2S to chiralα,β-unsaturated N-acyl oxazolidinones has been achieved.The synthetic procedure was applied ...Asymmetric conjugated addition of allylcopper reagents derived from an allyl Grignard reagent and CuBr·Me_2S to chiralα,β-unsaturated N-acyl oxazolidinones has been achieved.The synthetic procedure was applied to the preparation of the key intermediate of the novel nonbenzodiazepine hypnotic drug,ramelteon.展开更多
基金the Shanghai Municipal Natural Science Foundation(No10ZR1409600)
文摘Asymmetric conjugated addition of allylcopper reagents derived from an allyl Grignard reagent and CuBr·Me_2S to chiralα,β-unsaturated N-acyl oxazolidinones has been achieved.The synthetic procedure was applied to the preparation of the key intermediate of the novel nonbenzodiazepine hypnotic drug,ramelteon.
