A novel method for the simultaneous determination of benserazide and levodopa using capillary electrophoresis （CE）- chemiluminescence （CL） has been developed. Under the optimal conditions, the detection limits （S...A novel method for the simultaneous determination of benserazide and levodopa using capillary electrophoresis （CE）- chemiluminescence （CL） has been developed. Under the optimal conditions, the detection limits （S/N = 3） were 1.85 μg/mL for benserazide and 0.12 μg/mL for levodopa. This method was successfully applied to the determination of benserazide and levodopa in Medopar tablet, the results showed that the detected values are in accordance with those by official methods.展开更多
The enhancing effect of benserazide on the chemiluminescence of luminol-potassium ferricyanide in alkaline medium was investigated, and a sensitive method for detecting benserazide has been developed by flow-injection...The enhancing effect of benserazide on the chemiluminescence of luminol-potassium ferricyanide in alkaline medium was investigated, and a sensitive method for detecting benserazide has been developed by flow-injection chemiluminescence＇s. The experimental results showed that the emission intensity is proportional to the concentration of benserazide in the range of 0.01-1.0 μg/mL, The detection limit （S/N=3） for benserazide turned out to be 0.9 ng/mL, and the relative standard deviation for 11 determinations of a 0.10μg/mL benserazide was 2.4%. The method was satisfactorily applied to the determination of benserazide in spiked urine samples.展开更多
基金This work was supported by Science Foundation of the National Education Ministry(No.206096)Education Department of Hubei Province(No.Z200522002),
文摘A novel method for the simultaneous determination of benserazide and levodopa using capillary electrophoresis （CE）- chemiluminescence （CL） has been developed. Under the optimal conditions, the detection limits （S/N = 3） were 1.85 μg/mL for benserazide and 0.12 μg/mL for levodopa. This method was successfully applied to the determination of benserazide and levodopa in Medopar tablet, the results showed that the detected values are in accordance with those by official methods.
基金supported by the Science Foundation of the National Education Department(No.206096)the Education Department of Hubei Province(No.Z200522002)the 0pen Foundation of Hubei Key Laboratory of Biotechnology in Traditional Chinese medicine(No.20040201).
文摘The enhancing effect of benserazide on the chemiluminescence of luminol-potassium ferricyanide in alkaline medium was investigated, and a sensitive method for detecting benserazide has been developed by flow-injection chemiluminescence＇s. The experimental results showed that the emission intensity is proportional to the concentration of benserazide in the range of 0.01-1.0 μg/mL, The detection limit （S/N=3） for benserazide turned out to be 0.9 ng/mL, and the relative standard deviation for 11 determinations of a 0.10μg/mL benserazide was 2.4%. The method was satisfactorily applied to the determination of benserazide in spiked urine samples.
