As a convenient approach to the characterization of cerebral cortex electrical information, electroencephalograph (EEG) has potential clinical application in monitoring the acupuncture effects. In this paper, a meth...As a convenient approach to the characterization of cerebral cortex electrical information, electroencephalograph (EEG) has potential clinical application in monitoring the acupuncture effects. In this paper, a method composed of the mutual information method and Lempel-Ziv complexity method (MILZC) is proposed to investigate the effects of acupuncture on the complexity of information exchanges between different brain regions based on EEGs. In the experiments, eight subjects are manually acupunctured at 'Zusanli' acupuncture point (ST-36) with different frequencies (i.e., 50, 100, 150, and 200 times/min) and the EEGs are recorded simultaneously. First, MILZC values are compared in general. Then average brain connections are used to quantify the effectiveness of acupuncture under the above four frequencies. Finally, significance index P values are used to study the spatiality of the acupuncture effect on the brain. Three main findings are obtained: (i) MILZC values increase during the acupuncture; (ii) manual acupunctures (MAs) with 100 times/rain and 150 times/min are more effective than with 50 times/min and 200 times/rain; (iii) contralateral hemisphere activation is more prominent than ipsilateral hemisphere's. All these findings suggest that acupuncture contributes to the increase of brain information exchange complexity and the MILZC method can successfully describe these changes.展开更多
感觉、运动或自主神经系统的异常病理活动与疼痛和痉挛等多种神经机能障碍有关。千频交流电(kilohertz frequency alternating current,KHFAC)刺激是一种阻断异常病理活动在外周神经内传导的有效方法,它在缓解相关神经机能障碍方面具有...感觉、运动或自主神经系统的异常病理活动与疼痛和痉挛等多种神经机能障碍有关。千频交流电(kilohertz frequency alternating current,KHFAC)刺激是一种阻断异常病理活动在外周神经内传导的有效方法,它在缓解相关神经机能障碍方面具有临床应用潜力。KHFAC产生的神经传导阻断受千频信号波形和参数、阻断电极设置和位置以及神经纤维类型和直径等因素影响,具有快速性、可控性、可逆性、局部作用和副作用小的特点。但是,在产生完全传导阻断前,KHFAC首先在靶向神经上激活一簇高频初始放电,这种初始响应可能导致肌肉抽搐或疼痛感。同时,在撤去KHFAC后处于阻断状态的靶向神经需要经历一段时间才能恢复正常传导能力,这是该技术导致的后续效应。目前,关于KHFAC阻断神经传导的生物物理机制假说包括千频信号诱发K+通道激活和Na+通道失活。本文首先介绍了KHFAC技术的电生理实验研究方法和计算模型仿真方法,然后综述目前关于KHFAC作用下神经传导阻断的研究进展,重点论述初始响应特性及消除方法、传导阻断的后续效应、刺激波形和参数的影响、电极设置与位置的影响以及该技术潜在的临床应用,同时归纳KHFAC阻断神经传导的生物物理机制,最后对该技术未来的相关研究进行展望。展开更多
基金supported by the Key Program of the National Natural Science Foundation of China (Grant No.50537030)the National Natural Science Foundation of China (Grant No.61072012)the Young Scientists Fund of the National Natural Science Foundation of China (Grant Nos.50907044,61104032,and 60901035)
文摘As a convenient approach to the characterization of cerebral cortex electrical information, electroencephalograph (EEG) has potential clinical application in monitoring the acupuncture effects. In this paper, a method composed of the mutual information method and Lempel-Ziv complexity method (MILZC) is proposed to investigate the effects of acupuncture on the complexity of information exchanges between different brain regions based on EEGs. In the experiments, eight subjects are manually acupunctured at 'Zusanli' acupuncture point (ST-36) with different frequencies (i.e., 50, 100, 150, and 200 times/min) and the EEGs are recorded simultaneously. First, MILZC values are compared in general. Then average brain connections are used to quantify the effectiveness of acupuncture under the above four frequencies. Finally, significance index P values are used to study the spatiality of the acupuncture effect on the brain. Three main findings are obtained: (i) MILZC values increase during the acupuncture; (ii) manual acupunctures (MAs) with 100 times/rain and 150 times/min are more effective than with 50 times/min and 200 times/rain; (iii) contralateral hemisphere activation is more prominent than ipsilateral hemisphere's. All these findings suggest that acupuncture contributes to the increase of brain information exchange complexity and the MILZC method can successfully describe these changes.
文摘感觉、运动或自主神经系统的异常病理活动与疼痛和痉挛等多种神经机能障碍有关。千频交流电(kilohertz frequency alternating current,KHFAC)刺激是一种阻断异常病理活动在外周神经内传导的有效方法,它在缓解相关神经机能障碍方面具有临床应用潜力。KHFAC产生的神经传导阻断受千频信号波形和参数、阻断电极设置和位置以及神经纤维类型和直径等因素影响,具有快速性、可控性、可逆性、局部作用和副作用小的特点。但是,在产生完全传导阻断前,KHFAC首先在靶向神经上激活一簇高频初始放电,这种初始响应可能导致肌肉抽搐或疼痛感。同时,在撤去KHFAC后处于阻断状态的靶向神经需要经历一段时间才能恢复正常传导能力,这是该技术导致的后续效应。目前,关于KHFAC阻断神经传导的生物物理机制假说包括千频信号诱发K+通道激活和Na+通道失活。本文首先介绍了KHFAC技术的电生理实验研究方法和计算模型仿真方法,然后综述目前关于KHFAC作用下神经传导阻断的研究进展,重点论述初始响应特性及消除方法、传导阻断的后续效应、刺激波形和参数的影响、电极设置与位置的影响以及该技术潜在的临床应用,同时归纳KHFAC阻断神经传导的生物物理机制,最后对该技术未来的相关研究进行展望。